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The pathways involved in sensing and responding to mechanical stimuli have important roles in maintaining cartilage health, and can contribute to disease when dysregulated. This Review discusses cartilage mechanosignalling pathways and how they can be targeted to treat osteoarthritis.
The results of a phase IIb study suggest that ianalumab, an anti-BAFF receptor antibody, could have disease-modifying effects in primary Sjögren syndrome.
In this Review, Choi et al. review the pathogenesis of cardiometabolic-renal comorbidities of gout and discuss potential therapies to concurrently reduce serum urate concentrations and risk of gout cardiometabolic-renal comorbidities.
In this Review, the authors summarize the clinical features, management and prognosis of acute exacerbation of interstitial lung disease in patients with rheumatic diseases, and discuss the definitions and diagnostic criteria for this often life-threatening condition.
A new study shows that resident memory T cells that accumulate in the synovium of arthritic joints contribute to site-specific disease flare, and could present a new therapeutic target.
Vasculitis, inflammation of the blood vessels, takes many forms and can affect every organ system, potentially causing kidney failure, vision loss and death. This Review describes current knowledge on the global incidence and prevalence patterns for various types of vasculitis.
Researchers have found that hypoxia in articular cartilage is associated with expression of DOT1L, which protects against cartilage damage in a mouse model of osteoarthritis.
In this Review, the authors introduce the application of artificial intelligence, in particular machine learning and deep learning, for improving multiple stages of MRI, including acquisition, processing and post-processing steps, for studying osteoarthritis.
New research suggests that macrophage migration inhibitory factor (MIF) might contribute to spondyloarthritis (SpA) by enhancing type 3 immunity, and could be a potential therapeutic target.
In this Review, the authors discuss the immunometabolic alterations involved in the pathogenesis of intervertebral disc degeneration, including the role of adipokines in impaired metabolism in intervertebral disc cells, and discuss opportunities for future research and development of new therapies.
A new study suggests that DNMT3A mutations associated with clonal haematopoiesis of indeterminate potential are linked to osteoporosis through IL-20-mediated osteoclastogenesis.
Inhibition of the soluble epoxide hydrolase enzyme prevents metabolism of anti-inflammatory epoxyeicosatrienoic acids and reduces pain in a mouse model of osteoarthritis.
New research reports that men with inflammatory arthritis experience an impact on sexual health beyond erectile dysfunction, affecting their emotional, mental, and social health. Training to empower health professionals to have conversations about sex could improve support for people with rheumatic diseases.
Smoking during adulthood is a known risk factor for seropositive rheumatoid arthritis (RA) but how exposure to passive smoking affects RA risk is uncertain. New data from the Nurses’ Health Study on passive smoking over a lifetime suggest childhood exposure could be an important factor for future RA development.
