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2013 has witnessed the maturation of imaging science with rheumatology research, in part due to large, public databases. Using imaging in osteoarthritis (OA) as an example, breakthroughs include further elucidation of the relationship between obesity and OA, and identification of the importance of bone and meniscus shape in OA development.
Concerns have been raised over an association between biologic agents used in the treatment of rheumatoid arthritis (RA) and noninfectious serious respiratory adverse events, particular in patients with pre-existing RA-associated interstitial lung disease (RA-ILD). In this Review, the current evidence regarding the comparative pulmonary safety of the available biologic therapies is discussed and a framework to guide treatment decisions is provided. The authors also identify the considerable gaps in our understanding of the associations between biologic agents and RA-ILD, and propose a research agenda aimed at addressing them.
Clinical, basic and translational research in systemic lupus erythematosus are fast-moving fields. 2013 has seen the publication of some potentially landmark papers, which not only explore the potential of novel agents but also glean new insights from past trials.
New studies demonstrate the development of anti-flagellin antibodies in patients with ankylosing spondylitis. Does their presence point to mucosal dysregulation as a pathogenic mechanism of the disease?
Rheumatoid arthritis is associated with a number of extra-articular complications, including inflammatory ophthalmological manifestations. In this Review, the authors describe the key features of episcleritis, scleritis and peripheral ulcerative keratitis in the context of rheumatoid arthritis, as well as provide insights into the management of each condition.