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Spondyloarthritis

Gut inflammation in SpA: flagellin joins the dance?

New studies demonstrate the development of anti-flagellin antibodies in patients with ankylosing spondylitis. Does their presence point to mucosal dysregulation as a pathogenic mechanism of the disease?

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References

  1. Wallis, D. et al. Elevated serum anti-flagellin antibodies implicate subclinical bowel inflammation in ankylosing spondylitis: an observational study. Arthritis Res. Ther. 15, R166 (2013).

    Article  Google Scholar 

  2. Mielants, H. & Veys, E. M. Ileal inflammation in B27-positive reactive arthritis. Lancet 323, 1072 (1984).

    Article  Google Scholar 

  3. Mielants, H. et al. The evolution of spondyloarthropathies in relation to gut histology. II. Histological aspects. J. Rheumatol. 22, 2273–2278 (1995).

    CAS  PubMed  Google Scholar 

  4. Laukens, D. et al. CARD15 gene polymorphisms in patients with spondyloarthropathies identify a specific phenotype previously related to Crohn's disease. Ann. Rheum. Dis. 64, 930–935 (2005).

    Article  CAS  Google Scholar 

  5. van Praet, L. et al. Microscopic gut inflammation in axial spondyloarthritis: a multiparametric predictive model. Ann. Rheum. Dis. 72, 414–417 (2013).

    Article  Google Scholar 

  6. van Praet, L. et al. Degree of bone marrow oedema in sacroiliac joints of patients with axial spondyloarthritis is linked to gut inflammation and male sex: results from the GIANT cohort. Ann. Rheum. Dis. http://dx.doi.org/10.1136/annrheumdis-2013-203854.

  7. van Praet, L., Jacques, P., van den Bosch, F. & Elewaut, D. The transition of acute to chronic bowel inflammation in spondyloarthritis. Nat. Rev. Rheumatol. 8, 288–295 (2012).

    Article  CAS  Google Scholar 

  8. Quinton, J. F. et al. Anti-Saccharomyces cerevisiae mannan antibodies combined with antineutrophil cytoplasmic autoantibodies in inflammatory bowel disease: prevalence and diagnostic role. Gut 42, 788–791 (1998).

    Article  CAS  Google Scholar 

  9. Targan, S. R. et al. Antibodies to CBir1 flagellin define a unique response that is associated independently with complicated Crohn's disease. Gastroenterology 128, 2020–2028 (2005).

    Article  CAS  Google Scholar 

  10. Mundwiler, M. L. et al. Inflammatory bowel disease serologies in ankylosing spondylitis patients: a pilot study. Arthritis Res. Ther. 11, R177 (2009).

    Article  Google Scholar 

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Correspondence to Dirk Elewaut.

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Jacques, P., Elewaut, D. Gut inflammation in SpA: flagellin joins the dance?. Nat Rev Rheumatol 10, 5–6 (2014). https://doi.org/10.1038/nrrheum.2013.191

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