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Genetic predisposition contributes to disease pathophysiology in irritable bowel syndrome (IBS). This Review provides a comprehensive overview of genetic research in IBS and discusses new concepts in IBS genetics.
Intestinal immune cell trafficking contributes to the pathogenesis of immune-mediated inflammatory diseases (IMIDs). This Review discusses the underlying immune cell trafficking mechanisms along the gut–liver, gut–joint and gut–brain axes and provides an overview of their implications for treatment options in IMIDs.
Advances in hepatitis B management are still not reaching most of the affected community. A major barrier to this translation is stigma. Research and clinical communities have a responsibility to mitigate stigma and ensure that the voices of the affected community are considered in decision-making conversations.
Experimental and clinical evidence supports a role of metabolic perturbation in the development of gut inflammation in inflammatory bowel disease (IBD). This Review discusses the role of diet and metabolic inflammation in IBD, outlining key concepts and highlighting the links between metabolism and inflammation in IBD.
Currently, there is no cure for hepatitis B virus (HBV) infection, which can lead to chronic liver disease and liver cancer, and only a few biomarkers are available. This Roadmap provides an overview of HBV serum biomarkers and their challenges.
Here, the authors provide an overview of benign liver tumours (hepatic haemangioma, focal nodular hyperplasia and hepatocellular adenoma), including pathogenesis, diagnosis and management. Insights into how molecular physiology could inform clinical practice are also highlighted.
In this Viewpoint, members of the Association of Black Gastroenterologists and Hepatologists discuss inclusivity and equity in academic medicine and give advice to Black students interested in a career in science or medicine.
