Machine consisting of pistons and cogs showing forces that produce RNA

Mechanical regulation of chromatin and transcription

  • Sirio Dupont
  • Sara A. Wickström
Review Article


  • Stylized multi-coloured Circos plot

    The past two decades have witnessed extraordinary technological and computational advances in nucleic acid sequencing. This Milestone timeline provides a perspective of major genomic sequencing-related developments in the 21st century.

  • Immune cells attacking cancer cells

    The immune system is constantly on the lookout for threats but can fail to spot cancer. Now, advanced sequencing technologies are enabling scientists to investigate the unique genetics of both cancers and immune responses in individual patients. This means researchers can develop treatments that boost the immune system and help the body win its battle against cancer.

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    Finding it hard to navigate the flood of scientific literature? The Nature Reviews journals filter and highlight the most impactful research. Take a look at this animation to learn how Nature Reviews Genetics can help you stay up-to-date, or visit


  • By studying the closest extant unicellular relatives of animals and fungi, a study in Nature contrasts the evolutionary trajectories leading to the origin of these groups.

    • Linda Koch
    Research Highlight
  • Cooper et al. report in Science the use of massively parallel reporter assays and CRISPR-based validation to characterize the function of noncoding variants in dementia.

    • Kirsty Minton
    Research Highlight
  • A new study in Cell has characterized genome-wide dosage sensitivity for 54 human disorders, providing insight into the causal genes and disease mechanisms associated with rare copy-number variants.

    • Dorothy Clyde
    Research Highlight
  • A study in Nature describes ‘DNA Typewriter’, a prime-editing-based DNA recording technology that can capture the order of large numbers of distinct molecular events in mammalian cells.

    • Kirsty Minton
    Research Highlight
Green or yellow, smooth or wrinkly peas in and out of pods.

Celebrating Mendel

Gregor Johann Mendel, considered by many the ‘father of modern genetics’, was born 200 years ago, on 20 July 1822.


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