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Volume 25 Issue 4, April 2024

Inspired by the Review on p237.

Cover design: Patrick Morgan

Research Highlights

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Journal Club

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Reviews

  • To successfully invade bacteria, bacteriophages and other mobile genetic elements must overcome numerous types of bacterial defence systems. Here, the authors review the discovery and mechanisms of direct inhibitors of bacterial defence systems, as well as their applications in biotechnology.

    • David Mayo-Muñoz
    • Rafael Pinilla-Redondo
    • Peter C. Fineran
    Review Article
  • In this Review, Hwang and co-authors outline single-molecule fluorescence imaging techniques that can be used in living cells to visualize individual molecules involved in the spatiotemporal regulation of gene expression. This Review also delves into the biological insights gained through these methodologies.

    • Dong-Woo Hwang
    • Anna Maekiniemi
    • Hanae Sato
    Review Article
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Perspectives

  • This Perspective reviews large-scale genomics and longitudinal phenomics efforts and the insights they can provide into wellness. The authors describe their vision for the transformation of the current health care from disease-oriented to data-driven, wellness-oriented and personalized population health.

    • James T. Yurkovich
    • Simon J. Evans
    • Leroy E. Hood
    Perspective
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