Ball of yarn unwinding into DNA strand making loops

New insights into genome folding by loop extrusion from inducible degron technologies

  • Elzo de Wit
  • Elphège P. Nora
Review Article


  • Stylized multi-coloured Circos plot

    Gregor Johann Mendel, considered by many the ‘father of modern genetics’, was born 200 years ago, on 20 July 1822. In commemoration of this milestone, this Nature Collection brings together articles that explore the origins of genetics and reflect on Mendel’s legacy, which continues to shape the field to this day.

  • Immune cells attacking cancer cells

    The immune system is constantly on the lookout for threats but can fail to spot cancer. Now, advanced sequencing technologies are enabling scientists to investigate the unique genetics of both cancers and immune responses in individual patients. This means researchers can develop treatments that boost the immune system and help the body win its battle against cancer.

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    The editors of Nature Reviews Genetics will be posting about the latest developments in research and policy, and providing news about the journal. If you have any questions or feedback for us, get in touch by email or on Twitter.

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    Finding it hard to navigate the flood of scientific literature? The Nature Reviews journals filter and highlight the most impactful research. Take a look at this animation to learn how Nature Reviews Genetics can help you stay up-to-date, or visit


  • This journal club by Elisa Oricchio highlights two studies published in 2012, which used chromatin conformation capture methods to detect the formation of self-interacting chromatin regions, known as topologically associating domains (TADs).

    • Elisa Oricchio
    Journal Club
  • Magda Bienko highlights a landmark paper by Lieberman-Aiden et al., which in 2009 reported the development of high-throughput chromosome conformation capture (Hi-C), revolutionizing the field of 3D genome biology.

    • Magda Bienko
    Journal Club
  • Two studies have revealed that the characteristic distribution of N6-methyladenosine (m6A) — an RNA modification known to be functionally important for mRNA metabolism among other processes — in mRNA is shaped by the exon junction complex during splicing.

    • Dorothy Clyde
    Research Highlight
  • Two new studies in Nature Biotechnology describe cellular recording systems that incorporate time-resolved optical signals into self-assembling protein filaments.

    • Darren J. Burgess
    Research Highlight
  • In this Journal club, Meritxell Huch recalls a dogma postulated by Hayflick in 1961, that the capacity for propagating primary epithelial cells with normal ploidy is limited — a theory that persisted until the advent of organoid cultures.

    • Meritxell Huch
    Journal Club
  • A study in Nature reports comprehensive, genome-wide mapping of the human methylome that provides mechanistic insights into gene regulation and offers great potential for analysis of cell-free DNA.

    • Kirsty Minton
    Research Highlight
A Nobel Prize medal against a background of pills and an electrocardiogra

Nobel Prize in Physiology or Medicine 2022

The 2022 Nobel Prize in Physiology or Medicine was awarded to Svante Pääbo "for his discoveries concerning the genomes of extinct hominins and human evolution".


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