Machine consisting of pistons and cogs showing forces that produce RNA

Mechanical regulation of chromatin and transcription

  • Sirio Dupont
  • Sara A. Wickström
Review Article


  • Stylized multi-coloured Circos plot

    Gregor Johann Mendel, considered by many the ‘father of modern genetics’, was born 200 years ago, on 20 July 1822. In commemoration of this milestone, this Nature Collection brings together articles that explore the origins of genetics and reflect on Mendel’s legacy, which continues to shape the field to this day.

  • Immune cells attacking cancer cells

    The immune system is constantly on the lookout for threats but can fail to spot cancer. Now, advanced sequencing technologies are enabling scientists to investigate the unique genetics of both cancers and immune responses in individual patients. This means researchers can develop treatments that boost the immune system and help the body win its battle against cancer.

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    The editors of Nature Reviews Genetics will be posting about the latest developments in research and policy, and providing news about the journal. If you have any questions or feedback for us, get in touch by email or on Twitter.

  • Researchers stranded on an island

    Finding it hard to navigate the flood of scientific literature? The Nature Reviews journals filter and highlight the most impactful research. Take a look at this animation to learn how Nature Reviews Genetics can help you stay up-to-date, or visit


    • Microbiome epidemiology associates microbial community features with health outcomes, traits or exposures in human host populations. In this Review, the authors discuss ways in which various microbiome features at varying levels of resolution (community, strain, pathway or gene) influence human health using established examples of microbiome-associated changes linked with host outcomes.

      • Hannah VanEvery
      • Eric A. Franzosa
      • Curtis Huttenhower
      Review Article
    • Inducible protein degradation technologies enable the depletion of loop extrusion factors within short time frames, leading to the rapid reconfiguration of the 3D genome. Nora and de Wit review insights from degron approaches into the molecular factors controlling genome folding and how these findings have changed our understanding of genome organization, including its role in transcription.

      • Elzo de Wit
      • Elphège P. Nora
      Review Article
    • Mendelian defects in genes encoding factors that regulate telomere length, structure and function cause telomeropathies, or telomere biology disorders (TBDs). The authors review confirmed as well as potential TBD-causing genes and their main functions in telomere biology. They also discuss genetic features that underlie the complex nature of these diseases.

      • Patrick Revy
      • Caroline Kannengiesser
      • Alison A. Bertuch
      Review Article
    • This Review discusses how chromosome tracing has deepened our understanding of the role of 3D chromatin topology in transcriptional regulation by helping to resolve open questions and opposing models rising from data generated by sequencing-based approaches, such as 3C and HiC.

      • Antonina Hafner
      • Alistair Boettiger
      Review Article
  • A paper in Nature Communications describes a framework for identifying seed traits in food crops that have health-promoting effects on the gut microbiome, with implications for crop improvement approaches.

    • Dorothy Clyde
    In Brief
  • A report in Molecular Cell identifies six new triggers of target-directed miRNA degradation, which are essential for normal Drosophila melanogaster embryogenesis.

    • Dorothy Clyde
    In Brief
  • A paper in Cancer Cell reports genetic ancestry-associated differences in clinical outcomes when using tumour mutational burden as a biomarker in the context of immune checkpoint inhibitor therapy.

    • Linda Koch
    Research Highlight
  • In this Journal Club article, María Ávila-Arcos discusses a paper on a medically relevant genetic variant that was found exclusively in Indigenous populations from the Americas. She describes how this work served as inspiration for the inclusion of more diverse populations in the 1000 Genomes Project.

    • María C. Ávila-Arcos
    Journal Club
  • A paper in Molecular Cell reports the characterization of a second functional light strand promoter (LSP2) in the mitochondrial genome, challenging the view that mitochondrial DNA replication and gene expression are coupled by their reliance on a single light strand promoter (LSP).

    • Dorothy Clyde
    Research Highlight
A Nobel Prize medal against a background of pills and an electrocardiogra

Nobel Prize in Physiology or Medicine 2022

The 2022 Nobel Prize in Physiology or Medicine was awarded to Svante Pääbo "for his discoveries concerning the genomes of extinct hominins and human evolution".


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