Image: Patrick Morgan

Focus issue on microbial genomics

Latest Reviews

  • Review Article |

    Gene expression is subjected to various random processes (referred to as ‘noise’) that contribute to variability in molecular phenotypes. As Eling, Morgan and Marioni describe, there are various challenges to studying this variability, such as disentangling its multilayered sources, distinguishing it from deterministic influences on cellular variability, modelling it with appropriate statistical methods and understanding its practical consequences.

    • Nils Eling
    • , Michael D. Morgan
    •  & John C. Marioni
  • Review Article |

    For appropriate control of gene expression, enhancers must communicate with the right target genes at the right time, typically over large genomic distances. In this Review, Schoenfelder and Fraser discuss our latest understanding of long-range enhancer–promoter crosstalk, including target-gene specificity, interaction dynamics, protein and RNA architects of interactions, roles of 3D genome organization and the pathological consequences of regulatory rewiring.

    • Stefan Schoenfelder
    •  & Peter Fraser
  • Review Article |

    Throughout evolution, DNA has been the primary medium of biological information storage. In this article, Ceze, Nivala and Strauss discuss how DNA can be adopted as a storage medium for custom data, as a potential future complement to current data storage media such as computer hard disks, optical disks and tape. They discuss strategies for coding, decoding and error correction and give examples of implementation both in vitro and in vivo.

    • Luis Ceze
    • , Jeff Nivala
    •  & Karin Strauss
  • Review Article |

    Despite the success of human genome-wide association studies (GWAS) in associating genetic variants and complex diseases or traits, criticisms of the usefulness of this study design remain. This Review assesses the pros and cons of GWAS, with a focus on the cardiometabolic field.

    • Vivian Tam
    • , Nikunj Patel
    • , Michelle Turcotte
    • , Yohan Bossé
    • , Guillaume Paré
    •  & David Meyre
  • Review Article |

    This article reviews recent advances in ancient pathogen genomics, from methodological improvements in retrieving whole genomes to evolutionary analyses of ancient pathogens that remain relevant to public health. Focusing on the evolutionary history of the plague pathogen Yersinia pestis, the authors present unique insights afforded by the study of ancient pathogen genomes.

    • Maria A. Spyrou
    • , Kirsten I. Bos
    • , Alexander Herbig
    •  & Johannes Krause

News & Comment

  • Research Highlight |

    A study in Nature describes a CRISPR–Cas9-based ‘molecular recorder’ that can report on cellular state and cell lineage, in mice, from fertilization through to adulthood.

    • Katharine H. Wrighton
  • Research Highlight |

    A study in Cell incorporates metabolic networks into a machine-learning approach to provide mechanistic insights into bacterial antibiotic lethality.

    • Darren J. Burgess
  • Editorial |

    Genomics has transformed the field of microbiology, but remaining challenges will need to be tackled for its benefits to be felt globally.

  • Research Highlight |

    A study in Science uses experimental and population genomic approaches to examine the molecular underpinnings of evolved pollution resistance in Gulf killifish.

    • Linda Koch
  • Research Highlight |

    A study of ancient horse genomes, described in Cell, reveals the existence of two now-extinct horse lineages and shows that modern breeding practices reduced genetic diversity in horses.

    • Katharine H. Wrighton
  • Research Highlight |

    A new study reports a genome-wide polygenic score (GPS) that is predictive of obesity, thus providing opportunities for early health interventions.

    • Darren J. Burgess

Collection

Overcoming challenges in rare genetic diseases

Artvile/Getty images

Overcoming challenges in rare genetic diseases

Rare genetic diseases affect more than 300 million people worldwide, so collectively are a major health burden.

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