Obesity and the kidney: mechanistic links and therapeutic advances
This Review outlines the potential mechanisms by which obesity might influence kidney function, but also presents evidence for the regulation of body weight by the kidney.
This Review outlines the potential mechanisms by which obesity might influence kidney function, but also presents evidence for the regulation of body weight by the kidney.
Interferon regulatory factors (IRFs) are well known as mediators of the antiviral response but there is growing appreciation of their role in metabolism. This Review discusses the current understanding of IRFs as metabolic regulators, with a particular focus on IRF3 and IRF4.