ADCs moving towards brain

Antibody–drug conjugates in brain tumours

Read our June issue to learn more about the activity of ADCs in primary and secondary brain tumours

  • Maximilian J. Mair
  • Rupert Bartsch
  • Matthias Preusser
Review Article


  • viral particles

    Read all the COVID-19-related contents published in our journal, which will be freely available during the pandemic

  • five diverse women

    This regularly updated collection of articles published in the Nature Reviews journals provides in-depth discussions of recent research and medical advances in fields covering women’s health in the broadest sense.


    • The authors of this Perspective propose that, with further improvement in detection efficiency, circulating tumour cells (CTCs), which are released early during cancer development, have the potential to be used for the early detection of clinically relevant, aggressive cancers. Thus, use of CTCs as diagnostic biomarkers might improve outcomes by enabling the identification of cancers at a stage at which they are more amenable to treatment while avoiding overtreatment of patients with indolent tumours.

      • Rachel Lawrence
      • Melissa Watters
      • Yong-Jie Lu
    • Long-term survival rates of patients with gastric cancer remain low, particularly in Western countries. This lack of progress, among other aspects, is likely to reflect a focus on empirical approaches that fail to account for the heterogeneity of gastric cancers. In this Review, the authors summarize the available evidence on the management of patients with early stage gastric cancers, with an emphasis on understanding the underlying biology in order to improve the outcomes in patients with these historically difficult-to-treat tumours.

      • Yuki Hirata
      • Ayesha Noorani
      • Jaffer A. Ajani
      Review Article
    • The effective management of treatment-related events remains an unmet need in oncology. The authors of this Review discuss the underlying biological mechanisms, risk factors, most commonly used pharmacological and non-pharmacological management strategies, and clinical practice guidelines for the most common long-term (continuing beyond treatment) and late or delayed (following treatment) adverse events associated with chemotherapy and other anticancer treatments.

      • Maryam B. Lustberg
      • Nicole M. Kuderer
      • Gary H. Lyman
      Review Article
    • Dysregulation of N6-methyladenosine (m6A), the most prevalent internal modification in eukaryotic mRNA, is common in various cancer types. The authors of this Review provide an overview of the mechanisms of m6A-dependent RNA regulation, summarize current knowledge of their pathological effects and potential utility as biomarkers in cancer, and describe ongoing efforts to develop small-molecule inhibitors of oncogenic m6A modifiers.

      • Xiaolan Deng
      • Ying Qing
      • Jianjun Chen
      Review Article
    • Cholangiocarcinoma is a malignancy that continues to be associated with a dismal prognosis, and a better understanding of the disease biology is required to improve early detection and treatment strategies. In this Review, the authors describe key scientific and clinical advances made in this area over the past 5 years, encompassing novel insights into the tumour stroma and immune microenvironment, promising progress in developing liquid biopsy approaches for diagnosis and monitoring, clinical translation of molecularly targeted therapies, emerging immunotherapies and reassessment of the potential role of liver transplantation.

      • Sumera I. Ilyas
      • Silvia Affo
      • Gregory J. Gores
      Review Article

Nature Careers


  • Faculty Positions at SUSTech School of Medicine

    Southern University of Science and Technology (SUSTech) is a public research university funded by Shenzhen city. Widely regarded as a pioneer and i...


    Southern University of Science and Technology (SUSTech)

  • Post-doctoral Fellow - Molecular Biology

    Post-doctoral Fellow in NOB, NCI, NIH Molecular and Cell Biology Program to investigate metabolic phenotype and molecular signaling in brain tumors.

    Bethesda, Maryland

    Neuro-Oncology Branch, NCI, NIH

  • Postdoctoral Research Associate - Oncology

    Summary   We are excited to announce a postdoctoral fellowship available in the laboratory of Dr. Charles Roberts in the Division of Molecular Onco...

    Memphis, Tennessee

    St. Jude Children's Research Hospital (St. Jude)

  • W2 professorship for psycho-oncological and psychosomatic health services research

    At the Faculty of Medicine of Rheinische Friedrich-Wilhelms-Universität Bonn, a   W2 professorship for psycho-oncological and psychosomatic health ...

    Bonn, Nordrhein-Westfalen (DE)

    Universitätsklinikum Bonn (AöR)

  • Postdoctoral Research Associate - Oncology

    Summary   Career Opportunity Division of Cancer Predisposition St Jude Children’s Research Hospital   The Nichols Lab at St. Jude Children's Resear...

    Memphis, Tennessee

    St. Jude Children's Research Hospital (St. Jude)