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DNA nanoswitch calipers can measure distances within single molecules with atomic resolution. Applied to single-molecule proteomics, they can enable the identification and quantification of molecules in trace samples via mechanical fingerprinting.
The effective absorption spectrum of metal-bound molecules and a rich plasmon-driven chemistry landscape are constructed by monitoring the interfacial environment of a thousand single nanocavities with slightly varied resonance energies.
The stimulation of interferon genes (STING) pathway with STING agonists such as cyclic dinucleotides (CDNs) has emerged as a promising immunotherapeutic approach. Here, the authors show that Mn2+ can amplify the STING-promoted anti-tumour immune response in challenging murine tumour models by coordinating with CDNs and self-assembling into nanoparticles that can be delivered locally and systemically.
Type I interferons (IFNs) have strong antitumour activity yet their clinical use is limited by their off-target toxicity and by their effect on immune evasion. Here the authors design a biomimetic nanoparticle loaded with an IFN inducer, which can at the same time replenish intratumoural IFNs and reduce their immunosuppressive activity, showing therapeutic efficacy in several animal tumour models.
Gas vesicles are air-filled protein nanostructures naturally expressed by certain bacteria and archaea to achieve cellular buoyancy. Here the authors show that, under the stimulation of pulsed ultrasound, targeted gas vesicles and gas vesicles expressed in genetically modified bacteria and mammalian cells release nanobubbles that, collapsing, lead to controlled mechanical damage of the surrounding biological milieu, demonstrating that, under focused ultrasound actuation, gas vesicles have potential applications as therapeutic agents.
Moiré-trapped interlayer excitons in a transition metal dichalcogenide heterobilayer serve as a sensitive optical probe of carrier filling in their immediate environment to characterize the doping of the moiré superlattice.
Tumours that grow on organ surfaces are difficult to eradicate as the complex topology of underlying tissues might hamper accessibility to tumour foci even after surgery. In this paper the authors engineer a peptide-based hydrogel that can be applied on surface tumours before or after resection, conform to the tissue underneath and release therapeutics.
Moiré trions are observed in electrostatically gated WSe2/MoSe2 heterobilayers, where photoluminescence polarization switching reveals a competition between valley-flip and spin-flip relaxation pathways of photo-excited carriers during trion formation.
Alloying copper with isolated heteroatoms enables the C protonation of CO2 to HCOO* on activated copper sites, resulting in exclusive electrochemical CO2-to-HCOOH conversion with considerably high activity.
Low-temperature ultraclean integration of large-area MoS2 thin-film transistors with nitride micro-LEDs through a back end of line process enables the demonstration of displays with high resolution and uniformity.
Small semiconductor nanocrystals control the assembly of larger plasmonic nanostructures through interfacial self-limiting aggregation, leading to permeable and colloidally stable photoactive hybrids for photocatalysis and tracking of light-induced electron transfer.
Although conventional analytical techniques can measure ensemble averages, single-molecule junctions can sense molecular reaction processes at the single-event level. The integration of a single-molecule Pd catalyst into a gapped graphene junction enables the electrical detection of a full catalytic cycle of the Suzuki–Miyaura coupling and clarifies the controversial transmetallation mechanism.
A trap, formed by a DNA-origami sphere docked onto a solid-state nanopore, allows the hydrodynamic trapping and label-free observation of single proteins, enabling nucleotide-dependent protein conformation to be discriminated on the timescale of submilliseconds to hours.
Spatiotemporal thermoelectric microscopy enables the observation of electronic heat flow in graphene in diffusive and hydrodynamic regimes at room temperature, as well as a controlled transition from a Fermi liquid to Dirac fluid.
Measuring the gate capacitance serves as a probe of the correlated states in MoSe2/WS2 moiré superlattices, which can be further controlled via sample–gate coupling.
Optical spectroscopy can identify chiral indices of individual carbon nanotubes, but has so far been unable to determine their handedness because of the weak chiroptical signal. Rayleigh scattering circular dichroism now enables the identification of both chiral indices and handedness of individual nanotubes.
Despite its great potential, immune checkpoint blockade has shown efficacy in only a restricted number of patients. In this Article, the authors present a nano-based platform for the co-delivery of chemo- and immunotherapeutics that shows efficient synergic antitumour activity in large, hard-to-treat tumour models.