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In vivo delivery of the CRISPR/Cas system is a promising cancer therapy approach, but its efficacy is hampered by low penetrability of nanoparticles in the stiff tumour tissue. Here the authors use dendrimer lipid nanoparticles to couple PD-L1 gene editing with knockdown of FAK, a protein involved in cell adhesion, showing that modulation of the mechanical properties of tumour cells leads to enhanced gene editing and tumour growth inhibition in four different animal models.
A nanomagnetic artificial spin ice array with two types of nanomagnets can host both magnetic macrospins and vortices. This enables highly reconfigurable magnon behaviour, which is leveraged for hardware neuromorphic computation.
Nitrate, a common pollutant in wastewater and groundwater, has been efficiently converted into valuable ammonia products via an electrochemical method using Ru-dispersed Cu nanowire as the catalyst.
The performance of nanostructured metal catalysts in acetylene hydrochlorination is governed by an interplay of nuclearity, coordination and host effects. The central activity descriptor is identified as the acetylene adsorption energy.
The ultrathin thickness, high pore density and short interpore distance of a COF monolayer endow an extremely low membrane resistance and strong pore–pore coupling, which greatly improves the membrane-based osmotic power generation.
A robust all-organic interfacial protective layer towards ultrahigh-rate and large-capacity Li metal anodes is proposed by rational integration of porous polymer-based molecular brushes with single-ion-conductive lithiated Nafion.
The incorporation of electron transport layers based on single-crystalline TiO2 rhombohedral nanoparticles enables the realization of stable and efficient large-area perovskite solar cell modules.
A microscopic robotic device is remotely controlled in two dimensions in all three degrees of freedom independently by the interaction between unfocused light and four plasmonic nanoantennas.
A Cu2+-crosslinked chitosan material with unique 1 nm hexagonal nanochannels is synthesized and applied as a high-performance and alkaline-stable hydroxide exchange membrane.
Motion is a key characteristic of every form of life. In this work, the authors use graphene drums to probe the nanomotion of a single bacterium and develop a new way for performing antibiotic susceptibility testing with single-cell resolution.
Deterministic single-photon sources are a key building block for photonic quantum technologies. Stimulated emission now helps tailoring spontaneous emission from a ladder-type three-level system in a single epitaxial quantum dot for bright polarized sources with a high photon purity and indistinguishability.
Cancer vaccines based on endogenous modified dendritic cells can activate cytotoxic T cells in an antigen-specific manner, but the short life of dendritic cells on injection in the body limits the efficacy of the strategies. Here the authors design biomimetic nanovesicles derived from antigen-presenting dendritic cell membranes for cancer vaccination and the simultaneous delivery of immune co-stimulatory molecules, showing robust antitumour activity in animal models.
This study provides insights into unifying mechanisms that explain the impact of engineered nanomaterials across species and identifies those that underlie differing sensitivities.
A two-dimensional transition metal dichalcogenide-on-compound-semiconductor fabrication method enables the realization of an active matrix micro-LED display.
A polyethersulfone–titanium dioxide membrane is demonstrated to be effective at micropollutant removal during the photocatalytic degradation of steroid hormones in a flow-through photocatalytic membrane reactor under UV light at environmentally relevant concentrations.
A low-cost plasmonic photocatalyst based on earth-abundant metals (Fe, Cu) maximizes solar energy conversion due to the concerted interplay of energies and interactions between reactants and hot carriers, thus producing aromatic amines with a high yield.