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A donor–acceptor molecule assembles with different molecular packing to form photocatalysts which selectively produce either H2 or H2O2, depending on the aggregate structure, a proof-of-concept of photoactivity polymorphism.
Although nanomedicine has shown benefits with respect to soluble drug administration, whether delivery of multiple drugs within the same nanocarrier has advantages over administration of single-drug nanomedicines or combination of free drugs at the same dosage is unclear. Here we use a bottlebrush prodrug platform to show that the delivery of three drugs in a synergistic combination in animal models outperforms other combinatorial approaches for multiple myeloma therapy.
Optically active semiconductor quantum dots have so far suffered from nuclear inhomogeneity limiting all dynamical decoupling measurements to a few microseconds. Lattice-matched GaAs–AlGaAs quantum dots now enable decoupling schemes to achieve a 0.11 ms spin coherence time.
A neuromorphic camera can localize single fluorescent particles to below 20 nm resolution and evaluate the diffusion trajectory with millisecond temporal precision.
Polymerase-chain-reaction-based methods used in clinic to identify respiratory viral infections cannot simultaneously detect multiple viruses or viral variants. Here nanopore nucleic acid sensing is coupled to programmable ribonuclease to simultaneously identify specific short RNA sequences of multiple viruses, without predetection steps such as sample purification or preamplification.
High-performance all-electrical control is a prerequisite for scalable silicon quantum computing. The switchable interaction between spins and orbital motion of electrons in silicon quantum dots now enables the electrical control of a spin qubit with high fidelity and speed, without the need for integrating a micromagnet.
Metasurfaces can solve Fredholm integral equations of the second kind for free-space radiation at optical wavelengths. To this end, an inverse-designed metagrating is coupled to a semitransparent mirror providing feedback to perform an analogue version of the Neumann series.
Catalyst microenvironment induced by mixed CO/CO2 feeds in an alkaline membrane assembly electrolyser determines the catalytic activity and product selectivity in CO2/CO electrolysis.
Although conventional innate immune stimuli contribute to immune activation, they induce exhausted immune cells, resulting in suboptimal cancer immunotherapy. Now, a kinetically activating nanoadjuvant can dynamically integrate two waves of innate immune stimuli, in terms of the order, duration and time window, which results in effective antitumour immunity without immune cell exhaustion.
Covalent confinement drives symmetry breaking in macromolecular arrangements, giving rise to layered low-symmetry self-assemblies of mesh networks in the sub-10-nm scale.
An antiviral and antibacterial cotton textile based on a fundamentally different principle of incorporating copper ions into the cotton structure at the atomic level is fabricated with excellent air/water retainability and superior mechanical stability.
K+ ions in sub-1-nm-diameter carbon nanotube pores are found to disobey the Nernst–Einstein relation by three orders of magnitude. This behaviour results from drastically different mechanisms for ion diffusion and electromigration inside these channels.
A graphdiyne-assisted ultrafast sparking synthesis platform is developed to synthesize a group of metastable nanomaterials, including single-atom materials, high-entropy alloys and high-entropy oxides.
Addressable DNA structures with lateral dimensions of ~2 µm can be self-assembled starting from over 1,000 distinct DNA-origami monomers via joint capture of the non-nearest neighbours.
Measuring the in situ activation status of T cells is important to gauge the efficacy of immunotherapy approaches. In this Article the authors design a chemical probe that binds to the T cell membrane and scavenges reactive oxygen species (ROS), preventing ROS-driven T cell exhaustion while serving as a magnetic resonance imaging probe to quantify T cell activity in tumours and predict radiotherapy outcomes.
Spin manipulation for quantum information processing often requires cost-intensive sample design and cryogenic temperatures. Now, surface functionalization of CsPbBr3 quantum dots enables coherent optical manipulation of hole spins under ambient conditions.
A molecular catalyst supported on carbon nanotubes efficiently transforms the notorious water pollutant 1,2-dichloroethane into a useful chemical feedstock ethylene in an electrified membrane filtration device.