Beata Edyta Mierzwa

Genome topology and gene expression

Latest Research

  • Article |

    Genetic deletion or transcriptional silencing of HERV-H elements in human pluripotent stem cells (hPSCs) eliminates nearby topologically associating domain boundaries, while de novo insertion of HERV-H elements can introduce new ones. Mutations of specific HERV-H elements can impact hPSC differentiation.

    • Yanxiao Zhang
    • , Ting Li
    • , Sebastian Preissl
    • , Maria Luisa Amaral
    • , Jonathan D. Grinstein
    • , Elie N. Farah
    • , Eugin Destici
    • , Yunjiang Qiu
    • , Rong Hu
    • , Ah Young Lee
    • , Sora Chee
    • , Kaiyue Ma
    • , Zhen Ye
    • , Quan Zhu
    • , Hui Huang
    • , Rongxin Fang
    • , Leqian Yu
    • , Juan Carlos Izpisua Belmonte
    • , Jun Wu
    • , Sylvia M. Evans
    • , Neil C. Chi
    •  & Bing Ren
  • Article |

    The authors generate cell lines deficient for 22 BAF subunits, studying effects on complex composition, chromatin accessibility and gene expression. They identify synthetic lethal interactions between SMARCA4–ARID2, SMARCA4–ACTB and SMARCC1–SMARCC2.

    • Sandra Schick
    • , André F. Rendeiro
    • , Kathrin Runggatscher
    • , Anna Ringler
    • , Bernd Boidol
    • , Melanie Hinkel
    • , Peter Májek
    • , Loan Vulliard
    • , Thomas Penz
    • , Katja Parapatics
    • , Christian Schmidl
    • , Jörg Menche
    • , Guido Boehmelt
    • , Mark Petronczki
    • , André C. Müller
    • , Christoph Bock
    •  & Stefan Kubicek
  • Article |

    Systematic analyses of large-scale genome-wide association data provide an overview of pleiotropy and genetic architecture for hundreds of human complex traits and diseases.

    • Kyoko Watanabe
    • , Sven Stringer
    • , Oleksandr Frei
    • , Maša Umićević Mirkov
    • , Christiaan de Leeuw
    • , Tinca J. C. Polderman
    • , Sophie van der Sluis
    • , Ole A. Andreassen
    • , Benjamin M. Neale
    •  & Danielle Posthuma
  • Letter |

    Genomic analysis of 906 Clostridium difficile strains shows that this enteropathogen is undergoing speciation, which is linked to the selection of genes involved in sporulation and in the metabolism of simple dietary sugars.

    • Nitin Kumar
    • , Hilary P. Browne
    • , Elisa Viciani
    • , Samuel C. Forster
    • , Simon Clare
    • , Katherine Harcourt
    • , Mark D. Stares
    • , Gordon Dougan
    • , Derek J. Fairley
    • , Paul Roberts
    • , Munir Pirmohamed
    • , Martha R. J. Clokie
    • , Mie Birgitte Frid Jensen
    • , Katherine R. Hargreaves
    • , Margaret Ip
    • , Lothar H. Wieler
    • , Christian Seyboldt
    • , Torbjörn Norén
    • , Thomas V. Riley
    • , Ed J. Kuijper
    • , Brendan W. Wren
    •  & Trevor D. Lawley
  • Letter |

    A mutation in RAS oncogene family-like 3 (RABL3) is discovered in a family with multiple cases of pancreatic cancer. Zebrafish modeling and biochemical approaches suggest that truncated RABL3 elevates KRAS activity via accelerated prenylation.

    • Sahar Nissim
    • , Ignaty Leshchiner
    • , Joseph D. Mancias
    • , Matthew B. Greenblatt
    • , Ophélia Maertens
    • , Christopher A. Cassa
    • , Jill A. Rosenfeld
    • , Andrew G. Cox
    • , John Hedgepeth
    • , Julia I. Wucherpfennig
    • , Andrew J. Kim
    • , Jake E. Henderson
    • , Patrick Gonyo
    • , Anthony Brandt
    • , Ellen Lorimer
    • , Bethany Unger
    • , Jeremy W. Prokop
    • , Jerry R. Heidel
    • , Xiao-Xu Wang
    • , Chinedu I. Ukaegbu
    • , Benjamin C. Jennings
    • , Joao A. Paulo
    • , Sebastian Gableske
    • , Carol A. Fierke
    • , Gad Getz
    • , Shamil R. Sunyaev
    • , J. Wade Harper
    • , Karen Cichowski
    • , Alec C. Kimmelman
    • , Yariv Houvras
    • , Sapna Syngal
    • , Carol Williams
    •  & Wolfram Goessling

News & Comment

  • News & Views |

    Far from being junk DNA, the pervasive retrotransposons that populate the genome have a powerful capacity to influence genes and chromatin. A new study demonstrates how the transcription of one such element, HERV-H, can modify the higher-order 3D structure of chromatin during early primate development.

    • Michael I. Robson
    •  & Stefan Mundlos
  • Editorial |

    Record high temperatures are being seen worldwide, thus placing strains on human health and disrupting the availability of essential resources such as food and water. Aberrant weather patterns in the form of intense storms or prolonged drought have put pressure on our agricultural systems and underscored the need for adaptation to a changing climate across many sectors. Complex problems require complex solutions, and genetic approaches could be a powerful tool for helping to mitigate the effects of climate change.

  • News & Views |

    Chromatin loops and domains are major organizational hallmarks of chromosomes. New work suggests, however, that these topological features of the genome are poor global predictors of gene activity, raising questions about their function.

    • Elizabeth H. Finn
    •  & Tom Misteli

About the Journal

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