We have curated a comprehensive single-cell reference map of the human breast. Our data explore how age, parity and germline mutations might influence cellular dynamics, revealing unexpected signs of immune exhaustion in healthy tissues from carriers of BRCA1 or BRCA2 germline mutations.
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References
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This is a summary of: Reed, A. D. et al. A single-cell atlas enables mapping of homeostatic cellular shifts in the adult human breast. Nat. Genet. https://doi.org/10.1038/s41588-024-01688-9 (2024).
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Mapping single-cell gene expression in the healthy human breast. Nat Genet 56, 565–566 (2024). https://doi.org/10.1038/s41588-024-01691-0
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DOI: https://doi.org/10.1038/s41588-024-01691-0
