This study establishes in vitro and in vivo systems to study mutagenesis and cancer genome evolution. Using microfluidics and mouse models, the method enables the dissection of co-occurring mutational processes and reveals that acute damage results in mirror-image mutation phasing between sister cells after a single mitosis.
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References
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This is a summary of: Ginno, P. A. et al. Single-mitosis dissection of acute and chronic DNA mutagenesis and repair. Nat. Genet. https://doi.org/10.1038/s41588-024-01712-y (2024).
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Finding the lost sister: mirror-image mutation phasing in mammalian mitotic sister cells. Nat Genet (2024). https://doi.org/10.1038/s41588-024-01713-x
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DOI: https://doi.org/10.1038/s41588-024-01713-x
