Volume 1 Issue 8, December 1999

A confocal section of a Drosophila wing imaginal disc. The anterior compartment (left) is wild-type; the posterior compartment (right) is transgenic (Dakt1 has been ectopically expressed with engrailed–GAL4). This confocal section is stained with Hoechst dye for nuclei (blue), rhodamine-conjugated phalloidin for actin (red) and FITC for Dakt1 (green). Note the larger size of cells ectopically expressing Dakt1. [Cover design: Majo Xeridat] [article, p. 500; news and views, p.E191]

Article

Pleiotropic cell-division defects and apoptosis induced by interference with survivin function

Fengzhi Li
Elizabeth J. Ackermann
Dario C. Altieri
Article 27 Oct 1999
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Coordination of calcium signalling by endothelial-derived nitric oxide in the intact liver

Sandip Patel
Lawrence D. Robb-Gaspers
Andrew P. Thomas
Article 27 Oct 1999
Ubiquitin-dependent degradation of TGF-β-activated Smad2

Roger S. Lo
Joan Massagué
Article 28 Oct 1999
Presenilin-1 mutations downregulate the signalling pathway of the unfolded-protein response

Taiichi Katayama
Kazunori Imaizumi
Masaya Tohyama
Article 29 Oct 1999
CUL-2 is required for the G1-to-S-phase transition and mitotic chromosome condensation in Caenorhabditis elegans

Hui Feng
Weiwei Zhong
Edward T. Kipreos
Article 02 Nov 1999
Cooperative symmetry-breaking by actin polymerization in a model for cell motility

Alexander van Oudenaarden
Julie A. Theriot
Article 08 Nov 1999
Cell-autonomous regulation of cell and organ growth in Drosophila by Akt/PKB

Javier Verdu
Michael A. Buratovich
Morris J. Birnbaum
Article 10 Nov 1999
Melanoma chondroitin sulphate proteoglycan regulates cell spreading through Cdc42, Ack-1 and p130^cas

Kathryn M. Eisenmann
James B. McCarthy
Joji Iida
Article 10 Nov 1999
Components of the spindle-assembly checkpoint are essential in Caenorhabditis elegans

Risa Kitagawa
Ann M. Rose
Article 11 Nov 1999

Top of page ⤴

Brief Communication

The yeast phosphatidylinositol-4-OH kinase Pik1 regulates secretion at the Golgi

Christiane Walch-Solimena
Peter Novick
Brief Communication 11 Nov 1999

Top of page ⤴

Editorial

Ten years of intercontinental research funding

Editorial 01 Dec 1999

Top of page ⤴

News & Views

From small flies come big discoveries about size control

Bruce A. Edgar
News & Views 01 Dec 1999
Lipids: defining the shape of things to come

Annette Thomas
News & Views 01 Dec 1999
Nitric oxide pumps up calcium signalling

Andrew Charles
News & Views 01 Dec 1999
SMAD destruction turns off signalling

Carl-Henrik Heldin
Peter ten Dijke
News & Views 01 Dec 1999
Breaking through an actin cloud

Ken Jacobson
News & Views 01 Dec 1999
Survivin’ cell-separation anxiety

John C. Reed
Steven I. Reed
News & Views 01 Dec 1999
A new piece in the telomere jigsaw

Amanda Tromans
News & Views 01 Dec 1999

Top of page ⤴

Historical Perspective

One hundred years of membrane permeability: does Overton still rule?

Qais Al-Awqati
Historical Perspective 01 Dec 1999

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Technology Review

‘Shocking’ developments in chick embryology: electroporation and in ovo gene expression

Nobue Itasaki
Sophie Bel-Vialar
Robb Krumlauf
Technology Review 01 Dec 1999

Top of page ⤴

Review Article

Bcl-2 proteins: regulators of apoptosis or of mitochondrial homeostasis?

Matthew G. Vander Heiden
Craig B. Thompson
Review Article 01 Dec 1999

Top of page ⤴

Volume 1 Issue 8, December 1999

Article

Pleiotropic cell-division defects and apoptosis induced by interference with survivin function

Coordination of calcium signalling by endothelial-derived nitric oxide in the intact liver

Ubiquitin-dependent degradation of TGF-β-activated Smad2

Presenilin-1 mutations downregulate the signalling pathway of the unfolded-protein response

CUL-2 is required for the G1-to-S-phase transition and mitotic chromosome condensation in Caenorhabditis elegans

Cooperative symmetry-breaking by actin polymerization in a model for cell motility

Cell-autonomous regulation of cell and organ growth in Drosophila by Akt/PKB

Melanoma chondroitin sulphate proteoglycan regulates cell spreading through Cdc42, Ack-1 and p130^cas

Components of the spindle-assembly checkpoint are essential in Caenorhabditis elegans

Brief Communication

The yeast phosphatidylinositol-4-OH kinase Pik1 regulates secretion at the Golgi

Editorial

Ten years of intercontinental research funding

News & Views

From small flies come big discoveries about size control

Lipids: defining the shape of things to come

Nitric oxide pumps up calcium signalling

SMAD destruction turns off signalling

Breaking through an actin cloud

Survivin’ cell-separation anxiety

A new piece in the telomere jigsaw

Historical Perspective

One hundred years of membrane permeability: does Overton still rule?

Technology Review

‘Shocking’ developments in chick embryology: electroporation and in ovo gene expression

Review Article

Bcl-2 proteins: regulators of apoptosis or of mitochondrial homeostasis?

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