Abstract
SMAD proteins are key signal-transduction molecules whose activity must be tightly regulated. SMADs can be activated by phosphorylation, and at least one, Smad2, can be deactivated by degradation by protein-crunching proteasomes in the nucleus.
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Heldin, CH., ten Dijke, P. SMAD destruction turns off signalling. Nat Cell Biol 1, E195–E197 (1999). https://doi.org/10.1038/70223
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DOI: https://doi.org/10.1038/70223
