Review Articles

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  • In this Review, Andrew Modzelewski, Johnny Gan Chong, Ting Wang and Lin He discuss how sequences introduced by transposon activities provide raw material for genome innovation and document the distinct evolutionary path of each species.

    • Andrew J. Modzelewski
    • Johnny Gan Chong
    • Lin He
    Review Article
  • In this Review, Polyak and colleagues discuss cellular and microenvironmental mechanisms that contribute to intratumour heterogeneity and how this affects immune escape and tumour progression.

    • Zheqi Li
    • Marco Seehawer
    • Kornelia Polyak
    Review Article
  • Le et al. review various technologies for imaging RNAs in fixed and live cells and the biological insights gained from these technologies.

    • Phuong Le
    • Noorsher Ahmed
    • Gene W. Yeo
    Review Article
  • Rossiello et al. review the contributions of telomere shortening and/or dysfunction to ageing and a broad spectrum of age-associated human diseases.

    • Francesca Rossiello
    • Diana Jurk
    • Fabrizio d’Adda di Fagagna
    Review Article
  • In this Review, Hurley and colleagues cover the most recent discoveries and the emerging molecular understanding of the mechanisms of autophagosome formation.

    • Chunmei Chang
    • Liv E. Jensen
    • James H. Hurley
    Review Article
  • Legube and Marnef review the association between R-loops and DNA repair. They discuss how R-loops are formed near DNA double-strand breaks (DSBs) and how R-loops affect transcription near DSBs and DSB repair processes.

    • Aline Marnef
    • Gaëlle Legube
    Review Article
  • Karoutas and Akhtar review the roles of the nuclear lamina in chromatin-related functions, including transcription, epigenetic regulation and chromatin architecture, and their abnormalities in diseases and ageing.

    • Adam Karoutas
    • Asifa Akhtar
    Review Article
  • Qi and colleagues review CRISPR-based epigenome engineering technologies to modulate histone and DNA modifications and to perturb DNA and RNA regulatory elements and chromatin organization.

    • Muneaki Nakamura
    • Yuchen Gao
    • Lei S. Qi
    Review Article
  • Groth and colleagues discuss recent advances in chromatin replication and maintenance across mitotic division, with emphasis on replication-coupled chromatin assembly and chromatin maturation post-replication.

    • Kathleen R. Stewart-Morgan
    • Nataliya Petryk
    • Anja Groth
    Review Article
  • Harnessing DNA repair pathways in genome editing In this Review, Yeh, Richardson and Corn discuss the DNA repair pathways that underlie genome editing and recent improvements and strategies to yield desired genomic alterations in cells and organisms.

    • Charles D. Yeh
    • Christopher D. Richardson
    • Jacob E. Corn
    Review Article
  • In this Review, Caridi et al. discuss actin filaments in the nucleus and the functions of nuclear F-actin in response to DNA double-strand break repair.

    • Christopher Patrick Caridi
    • Matthias Plessner
    • Irene Chiolo
    Review Article
  • In this Review, the authors survey key advances in stem cell research and describe the cell types that are currently being used in the clinic or are close to clinical trials.

    • Michele De Luca
    • Alessandro Aiuti
    • Pamela Gehron Robey
    Review Article
  • Yao et al. review functions of lncRNAs in controlling chromatin architecture, transcription and nuclear bodies in the nucleus and in modulating mRNA stability, translation and protein modifications in the cytoplasm.

    • Run-Wen Yao
    • Yang Wang
    • Ling-Ling Chen
    Review Article
  • Sylvain et al. review cellular functions of various RNA modifications and their roles in regulating cell fate in normal and cancer tissues.

    • Sylvain Delaunay
    • Michaela Frye
    Review Article