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Unfolding emergency calls stress granules to the ER
Sensing stress within the endoplasmic reticulum (ER), the ER transmembrane protein IRE1α initiates a signal transduction pathway to restore homeostasis. A study finds that this process requires an ER membrane-bound phase separation event that leads to the local assembly of stress granules (SGs) and delivery of signalling components.
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Celebrating 25 years of cell biology
2024 marks twenty five years since the launch of Nature Cell Biology.