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Translational control by VARS in melanoma
Aminoacyl-tRNA synthetases can promote or suppress cancer progression by regulating codon-dependent translation. A study now shows that valine aminoacyl-tRNA synthetase (VARS) promotes therapeutic resistance of melanoma to MAPK pathway inhibitors by enhancing translation of valine-enriched genes, including the fatty acid oxidation gene HADH.
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Celebrating 25 years of cell biology
2024 marks twenty five years since the launch of Nature Cell Biology.