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A macroscopic fiber capable of transmitting electrical signal, light and drugs is pulled to create brain probes with a diameter <50 μm. Canales et al. demonstrate the utility of the probes for studying neural function in freely moving animals for extended periods of time (p 277).
Using conventional drug discovery and novel synthetic biology approaches, some investigators and companies are mining our resident microbes and their metabolites for targets in small-molecule drug programs. Ken Garber reports.
Ventures focusing on drug testing or therapies against rare disease, cancer, gastrointestinal disease, fibrosis and pain are among those selected by the editors in 2014's crop of startups.
Analyzing structural similarities between compounds derived from traditional oriental medicine and human metabolites is a systems-based approach that can help identify mechanisms of action and suggest approaches to reduce toxicity.
Method for combined genome and transcriptome sequencing from the same single cell shows that copy number variations influence cell-to-cell variability in gene expression levels.
Results from the Oxford nanopore minION sequencer “early-release” program enable identification of the insertion site of an antibiotic resistance island in Salmonella Typhi.
Liu et al. provide new resources for improving rice by cloning a gene cluster that enhances resistance to two species of planthoppers, which cause billions of dollars of crop loss.
A comprehensive analysis of RNA sequencing and single-nucleotide polymorphism (SNP) array data provides new insights into the biology of 675 human cancer cell lines
