Papers from the literature selected by the Nature Biotechnology editors. (Follow us on Twitter, @NatureBiotech #nbtHighlight)

LD Score regression distinguishes confounding from polygenicity in genome-wide association studies

Bulik-Sullivan, B.K. et al. Nat. Genetics doi:10.1038/ng.3211 (2 February 2015)

Detection of recurrent alternative splicing switches in tumor samples reveals novel signatures of cancer

Sebestyén, E. et al. Nucl. Acids Res. doi:10.1093/nar/gku1392 (1 January 2015)

Agrochemical control of plant water use using engineered abscisic acid receptors

Park, S.-Y. et al. Nature doi:10.1038/nature14123 (2 February 2015)

Expansion microscopy

Chen, F. et al. Science, 347, 543-548 (2015)

Extracellular metabolic energetics can promote cancer progression

Loo, J.M. et al. Cell, 160, 393-406 (2015)

Fixation-resistant photoactivatable fluorescent proteins for CLEM

Paez-Segala, M.G. et al. Nat. Methods doi:10.1038/nmeth.3225 (12 January 2015)