Perspectives

  • Perspective |

    Chien et al. reflect on lessons learned following the recent announcement that 31 papers from the Anversa laboratory on cardiac cell therapy are being retracted.

    • Kenneth R. Chien
    • , Jonas Frisén
    • , Regina Fritsche-Danielson
    • , Douglas A. Melton
    • , Charles E. Murry
    •  & Irving L. Weissman
  • Perspective | | open

    This paper presents standards and best practices for reporting genome sequences of uncultivated viruses.

    • Simon Roux
    • , Evelien M Adriaenssens
    • , Bas E Dutilh
    • , Eugene V Koonin
    • , Andrew M Kropinski
    • , Mart Krupovic
    • , Jens H Kuhn
    • , Rob Lavigne
    • , J Rodney Brister
    • , Arvind Varsani
    • , Clara Amid
    • , Ramy K Aziz
    • , Seth R Bordenstein
    • , Peer Bork
    • , Mya Breitbart
    • , Guy R Cochrane
    • , Rebecca A Daly
    • , Christelle Desnues
    • , Melissa B Duhaime
    • , Joanne B Emerson
    • , François Enault
    • , Jed A Fuhrman
    • , Pascal Hingamp
    • , Philip Hugenholtz
    • , Bonnie L Hurwitz
    • , Natalia N Ivanova
    • , Jessica M Labonté
    • , Kyung-Bum Lee
    • , Rex R Malmstrom
    • , Manuel Martinez-Garcia
    • , Ilene Karsch Mizrachi
    • , Hiroyuki Ogata
    • , David Páez-Espino
    • , Marie-Agnès Petit
    • , Catherine Putonti
    • , Thomas Rattei
    • , Alejandro Reyes
    • , Francisco Rodriguez-Valera
    • , Karyna Rosario
    • , Lynn Schriml
    • , Frederik Schulz
    • , Grieg F Steward
    • , Matthew B Sullivan
    • , Shinichi Sunagawa
    • , Curtis A Suttle
    • , Ben Temperton
    • , Susannah G Tringe
    • , Rebecca Vega Thurber
    • , Nicole S Webster
    • , Katrine L Whiteson
    • , Steven W Wilhelm
    • , K Eric Wommack
    • , Tanja Woyke
    • , Kelly C Wrighton
    • , Pelin Yilmaz
    • , Takashi Yoshida
    • , Mark J Young
    • , Natalya Yutin
    • , Lisa Zeigler Allen
    • , Nikos C Kyrpides
    •  & Emiley A Eloe-Fadrosh
  • Perspective |

    Machine learning and natural language processing methods are applied to learn from PubMed searches and improve user experience.

    • Nicolas Fiorini
    • , Robert Leaman
    • , David J Lipman
    •  & Zhiyong Lu
  • Perspective |

    Brendan Frey and colleagues provide a personal overview of the machine learning field and in particular deep learning. They outline the technical challenges in applying machine learning to different types of biological and biomedical data and go on to discuss the challenges in implementing these approaches in the clinical realm, in drug discovery programs and within regulatory agencies.

    • Michael Wainberg
    • , Daniele Merico
    • , Andrew Delong
    •  & Brendan J Frey
  • Perspective |

    Metabolomics activity screening can identify small-molecule metabolites that are readily available and can be used to alter phenotypes, including stem cell differentiation, T-cell survival, oligodendrocyte maturation, and insulin signaling.

    • Carlos Guijas
    • , J Rafael Montenegro-Burke
    • , Benedikt Warth
    • , Mary E Spilker
    •  & Gary Siuzdak
  • Perspective |

    An analysis of biotech and pharma stock prices since 1930 reveals sharp differences in the risk-adjusted returns of the two sectors.

    • Richard T Thakor
    • , Nicholas Anaya
    • , Yuwei Zhang
    • , Christian Vilanilam
    • , Kien Wei Siah
    • , Chi Heem Wong
    •  & Andrew W Lo
  • Perspective |

    Recent developments in bioengineering promise the possibility of new diagnostic and treatment strategies, novel industrial processes, and innovative approaches to thorny problems in fields such as nutrition, agriculture, and biomanufacturing. As modern genetics has matured and developed technologies of increasing power, debates over risk assessments and proper applications of the technology, and over who should have decision-making power over such issues, have become more prominent. Recently, some scientists have advocated that ethicists “step out of the way,” whereas others have called for greater ethical scrutiny, or even for moratoria on some lines of research. As a community, however, we must together determine the proper application of these powerful biological tools. This paper, a consensus statement of a group of interdisciplinary delegates drawn from the top biotech-producing countries of the world, offers a set of ethical principles to contribute to the ethical conversation about human cellular biotechnological research moving forward.

    • Paul Root Wolpe
    • , Karen S Rommelfanger
    •  & the Drafting and Reviewing Delegates of the BEINGS Working Groups
  • Perspective | | open

    Standards for sequencing the microbial 'uncultivated majority', namely bacterial and archaeal single-cell genome sequences, and genome sequences from metagenomic datasets, are proposed.

    • Robert M Bowers
    • , Nikos C Kyrpides
    • , Ramunas Stepanauskas
    • , Miranda Harmon-Smith
    • , Devin Doud
    • , T B K Reddy
    • , Frederik Schulz
    • , Jessica Jarett
    • , Adam R Rivers
    • , Emiley A Eloe-Fadrosh
    • , Susannah G Tringe
    • , Natalia N Ivanova
    • , Alex Copeland
    • , Alicia Clum
    • , Eric D Becraft
    • , Rex R Malmstrom
    • , Bruce Birren
    • , Mircea Podar
    • , Peer Bork
    • , George M Weinstock
    • , George M Garrity
    • , Jeremy A Dodsworth
    • , Shibu Yooseph
    • , Granger Sutton
    • , Frank O Glöckner
    • , Jack A Gilbert
    • , William C Nelson
    • , Steven J Hallam
    • , Sean P Jungbluth
    • , Thijs J G Ettema
    • , Scott Tighe
    • , Konstantinos T Konstantinidis
    • , Wen-Tso Liu
    • , Brett J Baker
    • , Thomas Rattei
    • , Jonathan A Eisen
    • , Brian Hedlund
    • , Katherine D McMahon
    • , Noah Fierer
    • , Rob Knight
    • , Rob Finn
    • , Guy Cochrane
    • , Ilene Karsch-Mizrachi
    • , Gene W Tyson
    • , Christian Rinke
    • , The Genome Standards Consortium
    • , Nikos C Kyrpides
    • , Lynn Schriml
    • , George M Garrity
    • , Philip Hugenholtz
    • , Granger Sutton
    • , Pelin Yilmaz
    • , Folker Meyer
    • , Frank O Glöckner
    • , Jack A Gilbert
    • , Rob Knight
    • , Rob Finn
    • , Guy Cochrane
    • , Ilene Karsch-Mizrachi
    • , Alla Lapidus
    • , Folker Meyer
    • , Pelin Yilmaz
    • , Donovan H Parks
    • , A Murat Eren
    • , Lynn Schriml
    • , Jillian F Banfield
    • , Philip Hugenholtz
    •  & Tanja Woyke
  • Perspective |

    • Sebastian Giwa
    • , Jedediah K Lewis
    • , Luis Alvarez
    • , Robert Langer
    • , Alvin E Roth
    • , George M Church
    • , James F Markmann
    • , David H Sachs
    • , Anil Chandraker
    • , Jason A Wertheim
    • , Martine Rothblatt
    • , Edward S Boyden
    • , Elling Eidbo
    • , W P Andrew Lee
    • , Bohdan Pomahac
    • , Gerald Brandacher
    • , David M Weinstock
    • , Gloria Elliott
    • , David Nelson
    • , Jason P Acker
    • , Korkut Uygun
    • , Boris Schmalz
    • , Brad P Weegman
    • , Alessandro Tocchio
    • , Greg M Fahy
    • , Kenneth B Storey
    • , Boris Rubinsky
    • , John Bischof
    • , Janet A W Elliott
    • , Teresa K Woodruff
    • , G John Morris
    • , Utkan Demirci
    • , Kelvin G M Brockbank
    • , Erik J Woods
    • , Robert N Ben
    • , John G Baust
    • , Dayong Gao
    • , Barry Fuller
    • , Yoed Rabin
    • , David C Kravitz
    • , Michael J Taylor
    •  & Mehmet Toner
  • Perspective |

    Modern biological research increasingly relies on image data as a primary source of information in unraveling the cellular and molecular mechanisms of life. The quantity and complexity of the data generated by state-of-the-art microscopes preclude visual or manual analysis and require advanced computational methods to fully explore the wealth of information. In addition to making bioimage analysis more efficient, objective, and reproducible, the use of computers improves the accuracy and sensitivity of the analyses and helps to reveal subtleties that may be unnoticeable to the human eye. Many methods and software tools have already been developed to this end, but there is still a long way to go before biologists can blindly trust automated measurements. Here, we summarize the current state of the art in bioimage analysis and provide a perspective on likely future developments.

    • Erik Meijering
    • , Anne E Carpenter
    • , Hanchuan Peng
    • , Fred A Hamprecht
    •  & Jean-Christophe Olivo-Marin
  • Perspective |

    GNPS is an open-access community-curated analysis platform for sharing natural product mass spectrometry data that enables continuous, automatic reanalysis of deposited 'living' data sets.

    • Mingxun Wang
    • , Jeremy J Carver
    • , Vanessa V Phelan
    • , Laura M Sanchez
    • , Neha Garg
    • , Yao Peng
    • , Don Duy Nguyen
    • , Jeramie Watrous
    • , Clifford A Kapono
    • , Tal Luzzatto-Knaan
    • , Carla Porto
    • , Amina Bouslimani
    • , Alexey V Melnik
    • , Michael J Meehan
    • , Wei-Ting Liu
    • , Max Crüsemann
    • , Paul D Boudreau
    • , Eduardo Esquenazi
    • , Mario Sandoval-Calderón
    • , Roland D Kersten
    • , Laura A Pace
    • , Robert A Quinn
    • , Katherine R Duncan
    • , Cheng-Chih Hsu
    • , Dimitrios J Floros
    • , Ronnie G Gavilan
    • , Karin Kleigrewe
    • , Trent Northen
    • , Rachel J Dutton
    • , Delphine Parrot
    • , Erin E Carlson
    • , Bertrand Aigle
    • , Charlotte F Michelsen
    • , Lars Jelsbak
    • , Christian Sohlenkamp
    • , Pavel Pevzner
    • , Anna Edlund
    • , Jeffrey McLean
    • , Jörn Piel
    • , Brian T Murphy
    • , Lena Gerwick
    • , Chih-Chuang Liaw
    • , Yu-Liang Yang
    • , Hans-Ulrich Humpf
    • , Maria Maansson
    • , Robert A Keyzers
    • , Amy C Sims
    • , Andrew R Johnson
    • , Ashley M Sidebottom
    • , Brian E Sedio
    • , Andreas Klitgaard
    • , Charles B Larson
    • , Cristopher A Boya P
    • , Daniel Torres-Mendoza
    • , David J Gonzalez
    • , Denise B Silva
    • , Lucas M Marques
    • , Daniel P Demarque
    • , Egle Pociute
    • , Ellis C O'Neill
    • , Enora Briand
    • , Eric J N Helfrich
    • , Eve A Granatosky
    • , Evgenia Glukhov
    • , Florian Ryffel
    • , Hailey Houson
    • , Hosein Mohimani
    • , Jenan J Kharbush
    • , Yi Zeng
    • , Julia A Vorholt
    • , Kenji L Kurita
    • , Pep Charusanti
    • , Kerry L McPhail
    • , Kristian Fog Nielsen
    • , Lisa Vuong
    • , Maryam Elfeki
    • , Matthew F Traxler
    • , Niclas Engene
    • , Nobuhiro Koyama
    • , Oliver B Vining
    • , Ralph Baric
    • , Ricardo R Silva
    • , Samantha J Mascuch
    • , Sophie Tomasi
    • , Stefan Jenkins
    • , Venkat Macherla
    • , Thomas Hoffman
    • , Vinayak Agarwal
    • , Philip G Williams
    • , Jingqui Dai
    • , Ram Neupane
    • , Joshua Gurr
    • , Andrés M C Rodríguez
    • , Anne Lamsa
    • , Chen Zhang
    • , Kathleen Dorrestein
    • , Brendan M Duggan
    • , Jehad Almaliti
    • , Pierre-Marie Allard
    • , Prasad Phapale
    • , Louis-Felix Nothias
    • , Theodore Alexandrov
    • , Marc Litaudon
    • , Jean-Luc Wolfender
    • , Jennifer E Kyle
    • , Thomas O Metz
    • , Tyler Peryea
    • , Dac-Trung Nguyen
    • , Danielle VanLeer
    • , Paul Shinn
    • , Ajit Jadhav
    • , Rolf Müller
    • , Katrina M Waters
    • , Wenyuan Shi
    • , Xueting Liu
    • , Lixin Zhang
    • , Rob Knight
    • , Paul R Jensen
    • , Bernhard Ø Palsson
    • , Kit Pogliano
    • , Roger G Linington
    • , Marcelino Gutiérrez
    • , Norberto P Lopes
    • , William H Gerwick
    • , Bradley S Moore
    • , Pieter C Dorrestein
    •  & Nuno Bandeira
  • Perspective |

    A long-held goal in sequencing has been to use a voltage-biased nanoscale pore in a membrane to measure the passage of a linear, single-stranded (ss) DNA or RNA molecule through that pore. With the development of enzyme-based methods that ratchet polynucleotides through the nanopore, nucleobase-by-nucleobase, measurements of changes in the current through the pore can now be decoded into a DNA sequence using an algorithm. In this Historical Perspective, we describe the key steps in nanopore strand-sequencing, from its earliest conceptualization more than 25 years ago to its recent commercialization and application.

    • David Deamer
    • , Mark Akeson
    •  & Daniel Branton
  • Perspective |

    The unprecedented number of fatalities in the PROPATRIA clinical trial using probiotics to treat patients with acute pancreatitis cast a shadow over the field. Bongaerts et al. provide rationales for the trial's high mortality rate and outline situations in which probiotic therapy may still be appropriate for this disease.

    • Ger P A Bongaerts
    •  & René S V M Severijnen
  • Perspective |

    Organ-level physiology is recapitulated in vitro by culturing cells in perfused, microfluidic devices.

    • Sangeeta N Bhatia
    •  & Donald E Ingber
  • Perspective |

    The synthetic biology research community describes a standard language for exchanging designs of biological 'parts'.

    • Michal Galdzicki
    • , Kevin P Clancy
    • , Ernst Oberortner
    • , Matthew Pocock
    • , Jacqueline Y Quinn
    • , Cesar A Rodriguez
    • , Nicholas Roehner
    • , Mandy L Wilson
    • , Laura Adam
    • , J Christopher Anderson
    • , Bryan A Bartley
    • , Jacob Beal
    • , Deepak Chandran
    • , Joanna Chen
    • , Douglas Densmore
    • , Drew Endy
    • , Raik Grünberg
    • , Jennifer Hallinan
    • , Nathan J Hillson
    • , Jeffrey D Johnson
    • , Allan Kuchinsky
    • , Matthew Lux
    • , Goksel Misirli
    • , Jean Peccoud
    • , Hector A Plahar
    • , Evren Sirin
    • , Guy-Bart Stan
    • , Alan Villalobos
    • , Anil Wipat
    • , John H Gennari
    • , Chris J Myers
    •  & Herbert M Sauro
  • Perspective |

    The authors propose that the increasing risk of biopharma investing can be reduced through megafunds that support many biomedical programs and attract investment from large institutions such as pension funds.

    • Jose-Maria Fernandez
    • , Roger M Stein
    •  & Andrew W Lo
  • Perspective |

    • Pelin Yilmaz
    • , Renzo Kottmann
    • , Dawn Field
    • , Rob Knight
    • , James R Cole
    • , Linda Amaral-Zettler
    • , Jack A Gilbert
    • , Ilene Karsch-Mizrachi
    • , Anjanette Johnston
    • , Guy Cochrane
    • , Robert Vaughan
    • , Christopher Hunter
    • , Joonhong Park
    • , Norman Morrison
    • , Philippe Rocca-Serra
    • , Peter Sterk
    • , Manimozhiyan Arumugam
    • , Mark Bailey
    • , Laura Baumgartner
    • , Bruce W Birren
    • , Martin J Blaser
    • , Vivien Bonazzi
    • , Tim Booth
    • , Peer Bork
    • , Frederic D Bushman
    • , Pier Luigi Buttigieg
    • , Patrick S G Chain
    • , Emily Charlson
    • , Elizabeth K Costello
    • , Heather Huot-Creasy
    • , Peter Dawyndt
    • , Todd DeSantis
    • , Noah Fierer
    • , Jed A Fuhrman
    • , Rachel E Gallery
    • , Dirk Gevers
    • , Richard A Gibbs
    • , Inigo San Gil
    • , Antonio Gonzalez
    • , Jeffrey I Gordon
    • , Robert Guralnick
    • , Wolfgang Hankeln
    • , Sarah Highlander
    • , Philip Hugenholtz
    • , Janet Jansson
    • , Andrew L Kau
    • , Scott T Kelley
    • , Jerry Kennedy
    • , Dan Knights
    • , Omry Koren
    • , Justin Kuczynski
    • , Nikos Kyrpides
    • , Robert Larsen
    • , Christian L Lauber
    • , Teresa Legg
    • , Ruth E Ley
    • , Catherine A Lozupone
    • , Wolfgang Ludwig
    • , Donna Lyons
    • , Eamonn Maguire
    • , Barbara A Methé
    • , Folker Meyer
    • , Brian Muegge
    • , Sara Nakielny
    • , Karen E Nelson
    • , Diana Nemergut
    • , Josh D Neufeld
    • , Lindsay K Newbold
    • , Anna E Oliver
    • , Norman R Pace
    • , Giriprakash Palanisamy
    • , Jörg Peplies
    • , Joseph Petrosino
    • , Lita Proctor
    • , Elmar Pruesse
    • , Christian Quast
    • , Jeroen Raes
    • , Sujeevan Ratnasingham
    • , Jacques Ravel
    • , David A Relman
    • , Susanna Assunta-Sansone
    • , Patrick D Schloss
    • , Lynn Schriml
    • , Rohini Sinha
    • , Michelle I Smith
    • , Erica Sodergren
    • , Aymé Spor
    • , Jesse Stombaugh
    • , James M Tiedje
    • , Doyle V Ward
    • , George M Weinstock
    • , Doug Wendel
    • , Owen White
    • , Andrew Whiteley
    • , Andreas Wilke
    • , Jennifer R Wortman
    • , Tanya Yatsunenko
    •  & Frank Oliver Glöckner
  • Perspective |

    Incompatible data storage formats have hindered the sharing and analyses of digital representations of biological pathways. BioPAX is a standardized language supported by >40 databases and software tools for exchanging pathway data.

    • Emek Demir
    • , Michael P Cary
    • , Suzanne Paley
    • , Ken Fukuda
    • , Christian Lemer
    • , Imre Vastrik
    • , Guanming Wu
    • , Peter D'Eustachio
    • , Carl Schaefer
    • , Joanne Luciano
    • , Frank Schacherer
    • , Irma Martinez-Flores
    • , Zhenjun Hu
    • , Veronica Jimenez-Jacinto
    • , Geeta Joshi-Tope
    • , Kumaran Kandasamy
    • , Alejandra C Lopez-Fuentes
    • , Huaiyu Mi
    • , Elgar Pichler
    • , Igor Rodchenkov
    • , Andrea Splendiani
    • , Sasha Tkachev
    • , Jeremy Zucker
    • , Gopal Gopinath
    • , Harsha Rajasimha
    • , Ranjani Ramakrishnan
    • , Imran Shah
    • , Mustafa Syed
    • , Nadia Anwar
    • , Özgün Babur
    • , Michael Blinov
    • , Erik Brauner
    • , Dan Corwin
    • , Sylva Donaldson
    • , Frank Gibbons
    • , Robert Goldberg
    • , Peter Hornbeck
    • , Augustin Luna
    • , Peter Murray-Rust
    • , Eric Neumann
    • , Oliver Ruebenacker
    • , Matthias Samwald
    • , Martijn van Iersel
    • , Sarala Wimalaratne
    • , Keith Allen
    • , Burk Braun
    • , Michelle Whirl-Carrillo
    • , Kei-Hoi Cheung
    • , Kam Dahlquist
    • , Andrew Finney
    • , Marc Gillespie
    • , Elizabeth Glass
    • , Li Gong
    • , Robin Haw
    • , Michael Honig
    • , Olivier Hubaut
    • , David Kane
    • , Shiva Krupa
    • , Martina Kutmon
    • , Julie Leonard
    • , Debbie Marks
    • , David Merberg
    • , Victoria Petri
    • , Alex Pico
    • , Dean Ravenscroft
    • , Liya Ren
    • , Nigam Shah
    • , Margot Sunshine
    • , Rebecca Tang
    • , Ryan Whaley
    • , Stan Letovksy
    • , Kenneth H Buetow
    • , Andrey Rzhetsky
    • , Vincent Schachter
    • , Bruno S Sobral
    • , Ugur Dogrusoz
    • , Shannon McWeeney
    • , Mirit Aladjem
    • , Ewan Birney
    • , Julio Collado-Vides
    • , Susumu Goto
    • , Michael Hucka
    • , Nicolas Le Novère
    • , Natalia Maltsev
    • , Akhilesh Pandey
    • , Paul Thomas
    • , Edgar Wingender
    • , Peter D Karp
    • , Chris Sander
    •  & Gary D Bader
  • Perspective |

    • Frank D Sistare
    • , Frank Dieterle
    • , Sean Troth
    • , Daniel J Holder
    • , David Gerhold
    • , Dina Andrews-Cleavenger
    • , William Baer
    • , Graham Betton
    • , Denise Bounous
    • , Kevin Carl
    • , Nathaniel Collins
    • , Peter Goering
    • , Federico Goodsaid
    • , Yi-Zhong Gu
    • , Valerie Guilpin
    • , Ernie Harpur
    • , Alita Hassan
    • , David Jacobson-Kram
    • , Peter Kasper
    • , David Laurie
    • , Beatriz Silva Lima
    • , Romaldas Maciulaitis
    • , William Mattes
    • , Gérard Maurer
    • , Leslie Ann Obert
    • , Josef Ozer
    • , Marisa Papaluca-Amati
    • , Jonathan A Phillips
    • , Mark Pinches
    • , Matthew J Schipper
    • , Karol L Thompson
    • , Spiros Vamvakas
    • , Jean-Marc Vidal
    • , Jacky Vonderscher
    • , Elizabeth Walker
    • , Craig Webb
    •  & Yan Yu
  • Perspective |

    • Frank Dieterle
    • , Frank Sistare
    • , Federico Goodsaid
    • , Marisa Papaluca
    • , Josef S Ozer
    • , Craig P Webb
    • , William Baer
    • , Anthony Senagore
    • , Matthew J Schipper
    • , Jacky Vonderscher
    • , Stefan Sultana
    • , David L Gerhold
    • , Jonathan A Phillips
    • , Gérard Maurer
    • , Kevin Carl
    • , David Laurie
    • , Ernie Harpur
    • , Manisha Sonee
    • , Daniela Ennulat
    • , Dan Holder
    • , Dina Andrews-Cleavenger
    • , Yi-Zhong Gu
    • , Karol L Thompson
    • , Peter L Goering
    • , Jean-Marc Vidal
    • , Eric Abadie
    • , Romaldas Maciulaitis
    • , David Jacobson-Kram
    • , Albert F Defelice
    • , Elizabeth A Hausner
    • , Melanie Blank
    • , Aliza Thompson
    • , Patricia Harlow
    • , Douglas Throckmorton
    • , Shen Xiao
    • , Nancy Xu
    • , William Taylor
    • , Spiros Vamvakas
    • , Bruno Flamion
    • , Beatriz Silva Lima
    • , Peter Kasper
    • , Markku Pasanen
    • , Krishna Prasad
    • , Sean Troth
    • , Denise Bounous
    • , Denise Robinson-Gravatt
    • , Graham Betton
    • , Myrtle A Davis
    • , Jackie Akunda
    • , James Eric McDuffie
    • , Laura Suter
    • , Leslie Obert
    • , Magalie Guffroy
    • , Mark Pinches
    • , Supriya Jayadev
    • , Eric A Blomme
    • , Sven A Beushausen
    • , Valérie G Barlow
    • , Nathaniel Collins
    • , Jeff Waring
    • , David Honor
    • , Sandra Snook
    • , Jinhe Lee
    • , Phil Rossi
    • , Elizabeth Walker
    •  & William Mattes
  • Perspective |

    A group of scientists in the systems biology community propose visual conventions for drawing biological diagrams.

    • Nicolas Le Novère
    • , Michael Hucka
    • , Huaiyu Mi
    • , Stuart Moodie
    • , Falk Schreiber
    • , Anatoly Sorokin
    • , Emek Demir
    • , Katja Wegner
    • , Mirit I Aladjem
    • , Sarala M Wimalaratne
    • , Frank T Bergman
    • , Ralph Gauges
    • , Peter Ghazal
    • , Hideya Kawaji
    • , Lu Li
    • , Yukiko Matsuoka
    • , Alice Villéger
    • , Sarah E Boyd
    • , Laurence Calzone
    • , Melanie Courtot
    • , Ugur Dogrusoz
    • , Tom C Freeman
    • , Akira Funahashi
    • , Samik Ghosh
    • , Akiya Jouraku
    • , Sohyoung Kim
    • , Fedor Kolpakov
    • , Augustin Luna
    • , Sven Sahle
    • , Esther Schmidt
    • , Steven Watterson
    • , Guanming Wu
    • , Igor Goryanin
    • , Douglas B Kell
    • , Chris Sander
    • , Herbert Sauro
    • , Jacky L Snoep
    • , Kurt Kohn
    •  & Hiroaki Kitano
  • Perspective |

    • Markus J Herrgård
    • , Neil Swainston
    • , Paul Dobson
    • , Warwick B Dunn
    • , K Yalçin Arga
    • , Mikko Arvas
    • , Nils Blüthgen
    • , Simon Borger
    • , Roeland Costenoble
    • , Matthias Heinemann
    • , Michael Hucka
    • , Nicolas Le Novère
    • , Peter Li
    • , Wolfram Liebermeister
    • , Monica L Mo
    • , Ana Paula Oliveira
    • , Dina Petranovic
    • , Stephen Pettifer
    • , Evangelos Simeonidis
    • , Kieran Smallbone
    • , Irena Spasié
    • , Dieter Weichart
    • , Roger Brent
    • , David S Broomhead
    • , Hans V Westerhoff
    • , Betül Kürdar
    • , Merja Penttilä
    • , Edda Klipp
    • , Bernhard Ø Palsson
    • , Uwe Sauer
    • , Stephen G Oliver
    • , Pedro Mendes
    • , Jens Nielsen
    •  & Douglas B Kell