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The use of water for electrochemical hydrogenation and oxidation of organic species provides a sustainable route for synthesizing chemicals. The electrode types, general electrocatalyst selection principles and interface microenvironment control are elucidated, conducive to designing efficient electrocatalysts and reaction systems.
The Chemical Weapons Convention has a unique Scientific Advisory Board that ensures it keeps pace with science, and its implementing body is prepared for future challenges. It is a model that could be usefully applied to other disarmament treaties.
Organic-based triplet–triplet annihilation upconversion-mediated photochemical reactions utilize low-energy photons to obtain high-energy excited states leading to notable advancements in photoredox catalysis, photoactivation, 3D printing and immunotherapy. Classifications, design principles, challenges and possible solutions are discussed in this Review.
Targeted covalent inhibitors (TCIs) can react irreversibly with lysine in kinases and other proteins. Small molecule TCIs can have both broad or specific lysine targeting whereas peptide- and protein-based TCIs were shown to provide high target specificity for lysines in shallow protein surfaces.
Anion recognition in competitive, aqueous media remains a critical challenge. Bulk and local solvation models for anion recognition events are herein explored, as well as targeted design approaches to retain strong anion binding in highly polar media.
JWST collects vast amounts of information about exoplanets light years away from Earth. Back home, the measured optical constants of laboratory aerosols are critically input parameters in models to interpret the observational results.
Semiconducting polymers require narrow molecular weight distributions for optimal efficiency. Synthesizing such polymers is no easy task, however a combined ultrasonication-assisted Stille polymerization reaction could be the solution to this problem.
Gold catalysts have attracted attention for their ability to activate hydrogen towards the hydrogenation of organic molecules. This Review explores strategies to enhance hydrogen–gold interactions to help design new efficient hydrogenation catalysts.
Electrochemical devices enable clean energy technologies such as hydrogen cells, batteries and solar fuels. Their design is hindered by incomplete information about the electrochemical interface during operation. Complementary optoelectronic probes offer a path to improved mechanistic insights into such interfaces.
The unique properties of selenium have been exploited in protein science. This Review highlights the recent applications of selenium chemistry in protein chemical synthesis, modification, folding, stabilization, the preparation of therapeutic proteins and more.
Chemistry education research is a well-established field that has the potential to inform chemistry teaching at all levels. But to the uninitiated, much of the work can seem descriptive while quantitative studies often suffer from a lack of reproducibility. Here I delve into these characteristics and explain why this should not deter chemistry teachers from engaging.
DNA has emerged as an attractive substrate for molecular information processing. This Review explores the application of DNA for computing and data storage, as well as the route to integrate these fields.
This Review introduces solar reforming as an emerging technology to produce sustainable fuels and chemicals from diverse waste feedstocks using sunlight. The chemistry and concept of solar reforming, suggestions of key metrics and proposed directions to realize solar-powered refineries for a future circular economy are discussed.
Providing a stable and reliable supply of electrons is crucial for the future of quantum computing processors. Here, electron withdrawing groups are added to species which improve the flow of electrons.
This Review highlights the strategies and challenges for targeting RNA with small molecules in medicinal chemistry. It emphasizes their potential as drugs and tools for understanding complex biological processes while encouraging chemists to contribute to this field for future advances.
Performing logical operations with molecular excitons may provide opportunities for developing ultrafast, subnanometre and biocompatible computational architectures. This Roadmap outlines a framework for using multiexcitonic processes such as singlet fission and triplet–triplet annihilation to drive logical devices.
The reduction of molecular species containing arene to alkali metal cation interactions with other alkali metals has been found to contradict the expectation provided by simple considerations of relative reduction potentials.
By drawing inspiration from ion transport in biology, researchers have developed highly selective channels for the separation and enrichment of Li+ ions from complex aqueous solutions.
