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Microbial production of food and cosmetics is a promising technology with which to obtain sustainable and environmentally friendly compounds. This Review discusses the production of food and cosmetic compounds using metabolically engineered microorganisms and the systems metabolic engineering strategies that can be used to develop industrially competitive microbial strains and processes.
Single-cell multi-omics analysis allows spatial tissue profiling at the cellular and subcellular level. This Review discusses microchip-based platforms that can be designed for single-cell and spatial multi-omics for applications in biological and biomedical research.
Chemiluminescence imaging can be applied for the in vivo and in vitro assessment of biological activity. This Review discusses the design, mode of action and application of chemiluminescent probes for the detection of the activity and presence of enzymes and analytes in cancerous tissue.
The role of the gut microbiome in human health and disease is being increasingly recognized. This Review discusses microbiome engineering strategies to treat the dysbiosis of the gut microbiota, which has been linked to the pathogenesis of multiple human diseases.
Women’s health has long been overlooked in both fundamental and clinical research, which, sadly, also holds true for the bioengineering field — albeit things are slowly changing.
Cell co-culture can assist the fabrication process of cultured meat and improve the quality of the final product. This Review discusses relevant cell types and co-culture techniques, and examines their use for cultivated meat production.
An article in Advanced Healthcare Materials reports a phenotypic epithelial-to-mesenchymal transition (EMT) screening platform based on an organic electrochemical transistor that allows real-time, non-invasive monitoring of extracellular vesicles-induced EMT and the screening of antimetastatic drugs.
At Pulmobiotics, we engineer bacteria for the treatment of respiratory diseases. Here, we outline how we designed MycoChassis — an attenuated bacterium strain obtained by genome engineering of Mycoplasma pneumoniae (a human lung pathogen) — and discuss the challenges on the road to its clinical translation.
The UNANO consortium consists of laboratories from eight European research universities that explore biomolecules as building blocks for the assembly of nanostructures and nanomachines. UNANO aims at uniting bionanotechnology researchers across Europe and transcending disciplinary boundaries to synergize research impact and explore applications of bionanotechnology.
An article in Science Robotics reports an in situ deployable electrode system, actuated with a soft robotic mechanism, that can be surgically implanted and cover large areas of the cortex.
An article in Nature Biomedical Engineering reports a simple and hardware-independent peptide-mediated delivery method for the CRISPR-mediated engineering of T cells.
Animal cells can be cultured in vitro to fabricate meat-like, edible products with the aim to provide a sustainable source of animal protein while improving animal welfare and reducing the environmental impact of meat production. CellX is a China-based startup company that aims to commercialize cultured meat in China.
Renal function can be replaced by bioengineered kidney tissue. This Review discusses in vivo kidney engineering, xenotransplantation, blastocyst complementation and stem-cell-derived kidney tissue engineering as approaches for renal replacement therapy.
Scientific knowledge is mostly communicated in English, which may pose a barrier for non-native English speakers in writing and talking about their research. However, scientific communication can be improved by following some simple rules and taking advantage of old and new tools.
Continuous monitoring of diverse biomolecular signatures has the potential to transform our understanding of personalized and preventative medicine. This Review Article discusses the emerging trends and pertinent considerations for the development of a new generation of body-based biomolecular sensors for in vivo measurement.
Owing to the high failure rates of the current drug development process, biomedical research is undergoing a paradigm shift towards approaches centred on human disease models. This Review critically discusses translationally relevant examples and defines key milestones for their widespread application.
Healthcare hackathons can bring patient-users, problem-solvers and external stakeholders together to formulate individual patient-user problems and find innovative solutions. Lessons can be learned from open innovation research to organize hackathons that ultimately lead to the design of new patient-specific products.
Peptide epitopes of structural and signalling proteins constitute the language through which cells communicate and orchestrate biological processes. This Review provides a library of peptide epitopes that can serve as a molecular toolbox for the design of bioactive synthetic matrices.
