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A hydrogel-based metamaterial undergoing shape and optical changes amplified in response to antibody-mediated biorecognition can be used to molecularly profile extracellular vesicles in ascites fluid from patients with cancer.
A tomographic method for the location of photon pairs originating from the annihilation of positron–electron pairs produced by high-energy X-rays in tissue could allow for the monitoring of radiotherapy dosing.
Closed-loop optogenetic stimulation with excitatory opsins enables the precise manipulation of neural dynamics in brain slices from transgenic mice and in anaesthetized non-human primates.
Radionuclide brachytherapy delivered via an injectable biopolymer depot conjugated with iodine-131 and combined with systemically delivered paclitaxel induced the complete regression of multiple subcutaneous and orthotopic pancreatic tumours in mice.
Collagen-binding peptides identified via phage display can be used to enhance the homing of mesenchymal stem cells to osteoarthritic tissue, its lubrication by hyaluronic acid and its visualization via magnetic resonance imaging.
An antibiotic identified via molecular-docking simulations and screening, and loaded into a bone-cement matrix, performs better than currently used antibiotic-loaded bone cements in the treatment of staphylococcal bone infections in rats.
Two variants of the adeno-associated virus serotype 9 engineered to display specific cell-penetrating peptides on the capsid show enhanced transduction of cells of the central nervous system in small and large animals.
A self-supervised deep-learning algorithm searches for and retrieves gigapixel whole-slide images at speeds that are independent of the size of the image repository
Optimized ultraflexible electrode arrays enable months-long electrophysiological recordings of several thousand neurons at densities of up to 1,000 neural units per cubic millimetre.
A customizable soft robotic aortic sleeve can recapitulate the haemodynamics and biomechanics of aortic stenosis, as shown in a porcine model of the disease.
Göttingen minipigs genetically engineered to carry a mini-repertoire of human genes for immunoglobulin antibodies allow for the toxicological testing of human recombinant antibodies.
Ultraviolet photoacoustic microscopy in reflection mode can be used to intraoperatively evaluate undecalcified and decalcified thick bone specimens without sectioning them.
A self-supervised model trained on chest X-ray images that lack explicit annotations performs pathology-classification tasks with accuracies comparable to those of radiologists.
Bioresorbable silicon-based optoelectronic thin films can selectively excite or inhibit neural activities, as shown in mice with exposed sciatic nerves and somatosensory cortices.
A molecular beacon engineered to be activated by the enzyme apurinic/apyrimidinic endonuclease 1 in inflammatory cells enables the specific and sensitive optical detection of inflammation in live mice.
Iterative expansion microscopy enables the use of confocal microscopes to uncover nanostructures in expanded yet otherwise intact tissues at a resolution of about 20 nm, as shown with the imaging of periodic amyloid nanoclusters in brain tissue.
The optical detection of two virulence factors of Mycobacterium tuberculosis on extracellular vesicles in blood allowed for the diagnosis of tuberculosis in paediatric cases that were missed by clinical microbiological assays.
Pathogenic autoreactive antibodies associated with severe COVID-19 can be identified via self-assembled genome-scale libraries of full-length proteins covalently coupled to uniquely identifying DNA barcodes for analysis by sequencing.
Graph deep learning can leverage information in the tumour microenvironment to extract prognostic histopathological features from gigapixel-sized whole-slide images.