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Progress towards the Sustainable Development Goals
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Sertoli cell lysosomes and late-onset hypogonadism
Zhou and colleagues explore reversing testicular aging and late-onset hypogonadism by targeting lysosomal function in Sertoli cells. The aging-related transformation of Sertoli cells into a lipid-hoarding subtype with dysregulated phagolysosomes and autolysosomes was reversed using the TRPML channel agonist ML-SA1, which demonstrates the potential of this targeted therapy in alleviating testosterone decline and systemic male-aging phenotypes.
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Aging, longevity and age-related diseases
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Exposure to negative socio-emotional events induces sustained alteration of resting-state brain networks in older adults
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Human skeletal muscle aging atlas
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Human microglia show unique transcriptional changes in Alzheimer’s disease
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PD1 blockade improves survival and CD8+ cytotoxic capacity, without increasing inflammation, during normal microbial experience in old mice