Nature Aging
How long will we live? And how much of that time will comprise a healthy life? What is aging, and can we stop or even reverse the aging process? What is the connection between aging and disease? Can we predict the evolving trends in the aging of human populations and prepare our societies for what has been called the Silver Tsunami? These are some of the important questions that the broad field of aging research is trying to address and that together form one of the Grand Challenges of the twenty-first century. The mission of Nature Aging is to provide a unique multidisciplinary, unifying and highly visible publishing platform for the aging-research community. The journal is highly selective yet broad in its coverage, publishing research from across the entire spectrum of the field, ranging from the basic biology of aging to the impact of aging on society. The journal aims to foster interactions among different areas of this diverse field of research and to promote new and exciting ideas within and beyond the research community, to enable synergy and maximize scientific and societal impact.
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© 2024 Macmillan Publishers Limited, part of Springer Nature. All rights reserved.
Nature Aging
© 2024 Macmillan Publishers Limited, part of Springer Nature. All rights reserved.
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Nature Aging
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https://www.nature.com/articles/s43587-024-00590-7
Nature Aging, Published online: 25 March 2024; doi:10.1038/s43587-024-00590-7In a longitudinal population-based cohort, Liu et al. demonstrate that integrating polygenic risk scores and the gut microbiome improved prediction, over traditional risk factors, for heart disease, diabetes, Alzheimer disease and prostate cancer.]]>
Yang LiuScott C. RitchieShu Mei TeoMatti O. RuuskanenOleg KamburQiyun ZhuJon SandersYoshiki Vázquez-BaezaKarin VerspoorPekka JousilahtiLeo LahtiTeemu NiiranenVeikko SalomaaAki S. HavulinnaRob KnightGuillaume MéricMichael Inouye
doi:10.1038/s43587-024-00590-7
Nature Aging, Published online: 2024-03-25; | doi:10.1038/s43587-024-00590-7
2024-03-25
Nature Aging
10.1038/s43587-024-00590-7
https://www.nature.com/articles/s43587-024-00590-7
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https://www.nature.com/articles/s43587-024-00605-3
Nature Aging, Published online: 22 March 2024; doi:10.1038/s43587-024-00605-3Intensive blood pressure control has been suggested to reduce the risk of adverse cardiovascular events. However, the effect of intensive blood pressure control on cardiac conduction system disease has not been clarified. Our study in older patients with hypertension identified no effect of intensive blood pressure control on cardiac conduction system diseases.]]>
doi:10.1038/s43587-024-00605-3
Nature Aging, Published online: 2024-03-22; | doi:10.1038/s43587-024-00605-3
2024-03-22
Nature Aging
10.1038/s43587-024-00605-3
https://www.nature.com/articles/s43587-024-00605-3
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https://www.nature.com/articles/s43587-024-00598-z
Nature Aging, Published online: 22 March 2024; doi:10.1038/s43587-024-00598-zTodorov-Völgyi, González-Gallego et al. provide a proteomic profiling of brain endothelium during aging to unveil changes undetected in transcriptomic studies, identifying a dysregulation of proteins involved in vesicle-mediated transport pathways, most prominently Arf6.]]>
Katalin Todorov-VölgyiJudit González-GallegoStephan A. MüllerNathalie BeaufortRainer MalikMartina SchiffererMihail Ivilinov TodorovDennis CrusiusSophie RobinsonAndree SchmidtJakob KörbelinFlorence BareyreAli ErtürkChristian HaassMikael SimonsDominik PaquetStefan F. LichtenthalerMartin Dichgans
doi:10.1038/s43587-024-00598-z
Nature Aging, Published online: 2024-03-22; | doi:10.1038/s43587-024-00598-z
2024-03-22
Nature Aging
10.1038/s43587-024-00598-z
https://www.nature.com/articles/s43587-024-00598-z
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https://www.nature.com/articles/s43587-024-00591-6
Nature Aging, Published online: 21 March 2024; doi:10.1038/s43587-024-00591-6Zhao, Deng and colleagues present a post hoc analysis of the STEP trial showing that intensive blood pressure control does not reduce the risk of cardiac conduction diseases in older adults with hypertension.]]>
Song ZhaoYue DengYixuan WangShikai YuJun HanJun CaiYi Zhang
doi:10.1038/s43587-024-00591-6
Nature Aging, Published online: 2024-03-21; | doi:10.1038/s43587-024-00591-6
2024-03-21
Nature Aging
10.1038/s43587-024-00591-6
https://www.nature.com/articles/s43587-024-00591-6
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https://www.nature.com/articles/s43587-024-00599-y
Nature Aging, Published online: 21 March 2024; doi:10.1038/s43587-024-00599-ySalvadó et al. developed and validated a CSF-based staging model for sporadic Alzheimer’s disease, which accurately reflects biomarker and clinical changes, enhancing diagnostic and prognostic assessments of participants for clinical setting and trials.]]>
Gemma SalvadóKanta HorieNicolas R. BarthélemyJacob W. VogelAlexa Pichet BinetteCharles D. ChenAndrew J. AschenbrennerBrian A. GordonTammie L. S. BenzingerDavid M. HoltzmanJohn C. MorrisSebastian PalmqvistErik StomrudShorena JanelidzeRik OssenkoppeleSuzanne E. SchindlerRandall J. BatemanOskar Hansson
doi:10.1038/s43587-024-00599-y
Nature Aging, Published online: 2024-03-21; | doi:10.1038/s43587-024-00599-y
2024-03-21
Nature Aging
10.1038/s43587-024-00599-y
https://www.nature.com/articles/s43587-024-00599-y
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https://www.nature.com/articles/s43587-024-00601-7
Nature Aging, Published online: 19 March 2024; doi:10.1038/s43587-024-00601-7After discovering the sensitivity of the adrenal zona reticularis region to aging, we found that low-density lipoprotein receptor (LDLR) deficiency hampers both cholesterol uptake and dehydroepiandrosterone sulfate (DHEA-S) production. This finding reveals the cellular basis for age-related adrenal insufficiency and provides insights for the development of interventions to delay endocrine and systemic aging.]]>
doi:10.1038/s43587-024-00601-7
Nature Aging, Published online: 2024-03-19; | doi:10.1038/s43587-024-00601-7
2024-03-19
Nature Aging
10.1038/s43587-024-00601-7
https://www.nature.com/articles/s43587-024-00601-7
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https://www.nature.com/articles/s43587-024-00588-1
Nature Aging, Published online: 19 March 2024; doi:10.1038/s43587-024-00588-1Wang et al. generate a single nucleus-resolved transcriptomic atlas of primate adrenal aging, with which they demonstrate regional changes in adrenal aging, and establish the role of LDLR in impeding cholesterol uptake and DHEA-S production in aging.]]>
Qiaoran WangXuebao WangBeibei LiuShuai MaFeng ZhangShuhui SunYaobin JingYanling FanYingjie DingMuzhao XiongJiaming LiQiaocheng ZhaiYandong ZhengChengyu LiuGang XuJiayin YangSi WangJinlin YeJuan Carlos Izpisua BelmonteJing QuGuang-Hui LiuWeiqi Zhang
doi:10.1038/s43587-024-00588-1
Nature Aging, Published online: 2024-03-19; | doi:10.1038/s43587-024-00588-1
2024-03-19
Nature Aging
10.1038/s43587-024-00588-1
https://www.nature.com/articles/s43587-024-00588-1
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https://www.nature.com/articles/s43587-024-00606-2
Nature Aging, Published online: 15 March 2024; doi:10.1038/s43587-024-00606-2Epidemiological studies reveal a correlation between hearing loss and the development and progression of Alzheimer’s disease (AD), but the underlying causal mechanisms remain unclear. A study now provides experimental evidence that hearing loss can promote AD via the growth differentiation factor 1 (GDF1) pathway, which may aid in developing potential AD therapeutic strategies.]]>
Hong-Bo ZhaoYang Yang
doi:10.1038/s43587-024-00606-2
Nature Aging, Published online: 2024-03-15; | doi:10.1038/s43587-024-00606-2
2024-03-15
Nature Aging
10.1038/s43587-024-00606-2
https://www.nature.com/articles/s43587-024-00606-2