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Reproductive aging

Sertoli cell lysosomes and late-onset hypogonadism

Nature Aging (2024)Cite this article

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Zhou and colleagues explore reversing testicular aging and late-onset hypogonadism by targeting lysosomal function in Sertoli cells. The aging-related transformation of Sertoli cells into a lipid-hoarding subtype with dysregulated phagolysosomes and autolysosomes was reversed using the TRPML channel agonist ML-SA1, which demonstrates the potential of this targeted therapy in alleviating testosterone decline and systemic male-aging phenotypes.

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Fig. 1: ML-SA1 induced rejuvenation in testicular dysfunction and LOH.

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Acknowledgements

We gratefully acknowledge grants from National Council for Scientific and Technological Development (CNPq-Brazil) (no. 402973/2022-4); and Brazilian Federal Agency for Support and Evaluation of Graduate Education (CAPES-Brazil), CAPES-PrInt, no. Finance Code 001. We also acknowledge the Portuguese Foundation for Science and Technology for funding to iBiMED (UIDP/04501/2020 and UIDB/04501/2020) and LAQVREQUIMTE (UIDB/50006/2020), co-funded by FEDER funds through the COMPETE/QREN, FSE/POPH, and POCI—COMPETE 2020 (POCI-01-0145-FEDER- 007491) funds.

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Authors and Affiliations

  1. Department of Biochemistry, Center of Biological Sciences, Federal University of Santa Catarina, Florianópolis, Brazil

    Ariane Zamoner

  2. LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, Aveiro, Portugal

    Pedro Fontes Oliveira

  3. Department of Medical Sciences, Institute of Biomedicine (iBiMED), University of Aveiro, Aveiro, Portugal

    Marco G. Alves

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  1. Ariane Zamoner
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  2. Pedro Fontes Oliveira
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  3. Marco G. Alves
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Correspondence to Ariane Zamoner, Pedro Fontes Oliveira or Marco G. Alves.

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Zamoner, A., Oliveira, P.F. & Alves, M.G. Sertoli cell lysosomes and late-onset hypogonadism. Nat Aging (2024). https://doi.org/10.1038/s43587-024-00622-2

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