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FOXP1 is a gatekeeper of cellular senescence with ovarian aging

Nature Aging volume 4, pages 451–452 (2024)Cite this article

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Our analysis of the spatiotemporal transcriptional features of human ovarian aging at the single-cell level identified the DNA damage response as a fundamental attribute in oocyte senescence. FOXP1, a gatekeeper both in granulosa and in theca and stroma cellular senescence, can be activated by quercetin treatment to delay ovarian aging.

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Fig. 1: Mapping spatiotemporal transcriptional features of human ovarian aging and reducing senescence with quercetin.

References

  1. Davis, S. R., Pinkerton, J., Santoro, N. & Simoncini, T. Menopause-biology, consequences, supportive care, and therapeutic options. Cell 186, 4038–4058 (2023). A review that presents ovarian aging as the pacemaker of female aging.

    Article  CAS  PubMed  Google Scholar 

  2. Laisk, T. et al. Demographic and evolutionary trends in ovarian function and aging. Hum. Reprod. Update. 25, 34–50 (2019). A review that presents the importance of ovarian aging research.

    CAS  PubMed  Google Scholar 

  3. Fan, X. et al. Single-cell reconstruction of follicular remodeling in the human adult ovary. Nat. Commun. 18, 3164 (2019). This paper reports human ovarian cell types.

    Article  Google Scholar 

  4. Lu, H. et al. Aging hallmarks of the primate ovary revealed by spatiotemporal transcriptomics. Protein Cell https://doi.org/10.1093/procel/pwad063 (2023). This paper presents hallmarks of primate ovarian aging.

    Article  PubMed  PubMed Central  Google Scholar 

  5. Shixuan W. (ed.) Ovarian Aging (Springer, 2023). This book presents the clinical and basic research progress of ovarian aging.

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This is a summary of: Wu, M. et al. Spatiotemporal transcriptomic changes of human ovarian aging and the regulatory role of FOXP1. Nat. Aging https://doi.org/10.1038/s43587-024-00607-1 (2024).

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FOXP1 is a gatekeeper of cellular senescence with ovarian aging. Nat Aging 4, 451–452 (2024). https://doi.org/10.1038/s43587-024-00608-0

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