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This paper describes the enrichment of rare neoplastic Hodgkin and Reed-Sternberg (HRSC) cells of classical Hodgkin lymphoma (cHL) from the archival formalin-fixed and paraffin-embedded tissues. This technique allows enrichment of HRSC from 1-5% in the initial cHL tissue to 40-80% in sorted populations, which enables robust genetic analysis of cHL by targeted high throughput sequencing and array-CGH.
Hepatocytic Bcl6 regulates sex-specific drug metabolism in the liver. In this paper the authors found that expression of male-dominant or female-dominant cytochrome P450 is altered in Bcl6 liver-specific knockout mice. Serum sex hormones and fertility did not change in these mice, suggesting that in this mouse model the effects are exclusively liver-specific.
In this report, the authors sought to determine whether expression of cadherin 11 in mesenchymal cells plays a critical role in ear morphogenesis. Cadherin 11 knockout mice show moderate hearing loss. The air-filled area of auditory bulla is reduced and residual mesenchymal cells are observed in the middle ear. This mutant mouse may be a promising animal model for elucidating the causes of conductive hearing loss.
A high phosphate diet accelerates cisplatin–induced acute kidney injury (AKI) progression to chronic kidney disease (CKD). Aging, male gender, and Klotho deficiency exacerbate and Klotho administration mitigates CKD progression, mineral disorders, and cardiovasculopathy. This is a technically simple model to study AKI-to-CKD transition, complications of CKD, and potential therapies.