Nature Reviews Molecular Cell Biology | Review Article
Metabolic regulation lies at the intersection of many research fields, including biochemistry, molecular and cell biology, physiology and the study of disease pathogenesis. Numerous advances have been made in our understanding of how metabolic pathways can be dynamically regulated by cellular events to meet the energy needs of the cell and maintain cell and organismal homeostasis. Dysregulation of these pathways, which influence signal transduction and gene expression, is linked to metabolic diseases such as obesity and type 2 diabetes, as well as to cancer and ageing.
This series features Review articles that discuss various aspects of the regulation of metabolic signalling, the interface between metabolic regulators and cellular processes and the implications of their deregulation for human diseases.