Collections

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    The functions of biomolecules, including lipids, nucleic acids and especially proteins are determined to a great extent by their structure. This structure–function relationship is a foundation of many physiological processes. In this article series, Nature Reviews Molecular Cell Biology collates Reviews that present important structural findings and illuminate their mechanistic and functional significance.

    Image: Science Lab / Alamy Stock Photo
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    A series of articles from Nature Reviews Molecular Cell Biology on protein synthesis and translation-associated protein quality control, and their deregulation in human disease.

    Image: Vicky Summersby
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    Metabolic pathways are dynamically regulated to meet the energy needs of the cell and maintain cell and organismal homeostasis. This series features Review articles that discuss various aspects of the regulation of metabolic signalling, the interface between metabolic regulators and cellular processes and the implications of their deregulation for human diseases.

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    This series of articles by Nature Reviews Molecular Cell Biology highlights different aspects of the biogenesis of various RNA species.

    Image: Vicky Summersby
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    This article series brings together Reviews that focus on key advances in understanding membrane biology as well as the regulation and functions of their lipid components, including their roles as bioactive molecules and their interplay with metabolism.

    Image: V. Summersby
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    In this article series, Nature Reviews Molecular Cell Biology looks at the progress that has been made in identifying resident stem cells in different tissues and in characterizing these often-heterogeneous stem cell pools, as well as in understanding the intrinsic mechanisms and interactions with stem cell niches (the specialized microenvironments in which they reside) that regulate stem cell function.

    Image: Vicky Summersby
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    Selected, recent articles from across the Nature Portfolio that document the recent progress in understanding the biology of EV-mediated cell–cell communication and advances in clinical translation of EVs.

    Image: Vicky Summersby
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    In this article series, Nature Reviews Molecular Cell Biology explores the pathways that preserve genomic integrity by detecting and repairing damage in different types of cellular DNA, highlighting new control mechanisms in the DNA damage response and the implications of disrupted repair pathways for disease.

    Image: Vicky Summersby
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    In this article series, Nature Reviews Molecular Cell Biology focuses on recent technological and technical advances and on their impact on diverse areas of molecular and cell biology. The articles highlight important biological issues, describe the technologies and techniques that were developed to tackle them and discuss the wealth of knowledge that using them has produced.

    Image: Vicky Summersby
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    The articles in this series discuss new insights that have been gained into how ‘old and new’ modifications are regulated and recognized, and how they crosstalk with one another to control fundamental biological processes.

    Image: Vicky Summersby
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    One of the fundamental biological processes in life is the cell cycle leading from DNA replication to cell division. While it has been studied for decades and our knowledge has matured, sophisticated experimental approaches have rejuvenated the field. In addition, cell cycle regulators have emerged as cancer therapy targets. This collection showcases ground-breaking cell cycle papers and reviews, ranging from basic discoveries to clinical applications.

    Image: Nicolas Plachta, NCB (2022)
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    Research interest is growing in profiling noncoding RNAs and understanding their biological functions in health and disease contexts.

    Image: Jeren (France) / Getty Images