Focus on molecular metrics

In this issue - pv

doi:10.1038/nchembio1007-v

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Focus on molecular metrics

Spatiotemporal mechanisms of life - p593

doi:10.1038/nchembio1007-593

Understanding how organisms measure and respond to space and time at a physical and chemical level is at the heart of a mechanistic understanding of life.

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The biology of time across different scales - pp594 - 597

Dean V Buonomano

doi:10.1038/nchembio1007-594

Animals time events on scales that span from microseconds to days. In contrast to the technologies devised by humans to keep track of time, biology has developed vastly different mechanisms for timing across these different scales.

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Memorizing spatiotemporal patterns - pp598 - 601

Atsushi Miyawaki & Satoshi Karasawa

doi:10.1038/nchembio1007-598

Live samples are intrinsically highly dynamic, yet techniques to monitor these complex environments usually reflect snapshots, thus making time-lapse imaging necessary to explore temporal progression of biological functions. Recent results indicate that exploiting some basic features of fluorescent protein maturation, such as green-to-red maturation of engineered proteins, should allow probing of temporally regulated information.

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Pamela Silver - p603

Catherine Goodman

doi:10.1038/nchembio1007-603

A continual commitment to exploring new scientific territory has led Pamela Silver on an oscillating path from physics and engineering to molecular biology and now to the development of engineering principles in the creation of cellular metrics.

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Conserved mechanisms regulate outgrowth in zebrafish fins - pp613 - 618

M Kathryn Iovine

doi:10.1038/nchembio.2007.36

Abstract - Conserved mechanisms regulate outgrowth in zebrafish fins | Full Text - Conserved mechanisms regulate outgrowth in zebrafish fins | PDF (1,902 KB) - Conserved mechanisms regulate outgrowth in zebrafish fins

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Prolyl cis-trans isomerization as a molecular timer - pp619 - 629

Kun Ping Lu, Greg Finn, Tae Ho Lee & Linda K Nicholson

doi:10.1038/nchembio.2007.35

Abstract - Prolyl : cis-trans: isomerization as a molecular timer | Full Text - Prolyl cis-trans isomerization as a molecular timer | PDF (2,147 KB) - Prolyl cis-trans isomerization as a molecular timer

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Mammalian circadian signaling networks and therapeutic targets - pp630 - 639

Andrew C Liu, Warren G Lewis & Steve A Kay

doi:10.1038/nchembio.2007.37

Abstract - Mammalian circadian signaling networks and therapeutic targets | Full Text - Mammalian circadian signaling networks and therapeutic targets | PDF (1,966 KB) - Mammalian circadian signaling networks and therapeutic targets

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Telomere length, stem cells and aging - pp640 - 649

Maria A Blasco

doi:10.1038/nchembio.2007.38

Abstract - Telomere length, stem cells and aging | Full Text - Telomere length, stem cells and aging | PDF (1,935 KB) - Telomere length, stem cells and aging