●RNA finds a simpler way Cech, T. R. Nature 18 March (2004) Ronald Breaker's group at Yale has identified a new class of ribozyme that functions as a metabolite-responsive genetic switch controlling expression of the glmS gene in Gram-positive bacteria. The implications of these findings are discussed in this News and Views article.

●Neutrophil NETworks Bell, E. Nature Reviews Immunology May (2004)

●The strain of being a prion Tuite, M. F. Nature 18 March (2004) Two recent publications in Nature that use the [PSI] yeast prion model to provide the long-awaited experimental proof of the prion 'protein-only' hypothesis are the subject of this News and Views article by Mick Tuite.

●TRIMming HIV's main sail Stevenson, M. Nature Immunology April (2004) Here, Mario Stevenson comments on the recent finding that the TRIM5α protein in monkey cells is the factor responsible for the fact that HIV-1 cannot infect cells from most non-human primates.

●A means to a DNA end: the many roles of Ku Downs, J. A. & Jackson, S. P. Nature Reviews Molecular Cell Biology May (2004)

●Resolution of acute inflammation — new opportunities for drug discovery Gilroy, D. W., Lawrence, T., Perretti, M. & Rossi, A. G. Nature Reviews Drug Discovery May (2004)

●Europe – Africa partnership set to launch clinical trials Nicholls, H. Nature Medicine April (2004) Reports on a new European and Developing Countries Clinical Trials Partnership initiative.

●Immunotherapeutic uses of CpG oligodeoxynucleotides Klinman, D. M. Nature Reviews Immunology May (2004)

●Advanced sequencing technologies: methods and goals Shendure, J., Mitra, R., Varma, C. & Church, G. M. Nature Reviews Genetics May (2004)

●Web debate: access to scientific literature The landscape of scientific publishing is changing rapidly. This new web focus from Nature will feature specially commissioned articles from key stakeholders — from leading scientists to publishers, librarians, learned societies and journal editors — setting out their views on what the future holds. Updated weekly, all the articles featured can be accessed free of charge.