●Deadly encounter: ubiquitin meets apoptosis. Jesenberger, V. & Jentsch, S. Nature Reviews Molecular Cell Biology February (2002)

●Chemokine receptors — multi-faceted therapeutic targets. Proudfoot, A. E. I. Nature Reviews Immunology February (2002)

●Juggling Jun. Weitzman, J. B. Nature Genetics February (2002) This News and Views article discusses the antagonistic roles of Jun family members.

●Apoptosis-based therapies. Reed, J. C. Nature Reviews Drug Discovery February (2002)

●Limits to lifespan. Lloyd, A. C. Nature Cell Biology February (2002) This commentary describes how extrinsic factors, as well as intrinsic factors, might limit the lifespan of somatic cells.

●The complex structure and dynamic evolution of human subtelomeres. Mefford, H. C. & Trask, B. J. Nature Reviews Genetics February (2002)

●The price of tumour suppression. Ferbeyre, G. & Lowe, S. Nature 3 January (2002) This News and Views article questions the use of upregulating p53 activity as an anticancer therapy, as it has also been shown to induce premature ageing in mice (see also 'Age activator' highlight on page 81 of this issue of Nature Reviews Cancer).

●Tumor viral escape from inhibited T cells. Welsh, R. M. et al. Nature Immunology February (2002) How do tumours escape from T-cell-mediated cell killing? In this News and Views article, Welsh et al . describe how an inhibitory receptor on T cells might control this effect.

●An essential link to mammary cancer? Tonko-Geymayer, S. & Doppler, W. Nature Medicine February (2002) Is IκBα the missing link in a pathway that controls mammary epithelial proliferation by upregulating cyclin D1? This News and Views article discusses the possibility.

●Cancer: molecular forecast refined. Caldas, C. & Aparicio, S. A. J. Nature 31 January (2002) How can we predict responses to therapy and clinical outcome of patients with cancer? This News and Views article describes how molecular forecasting using microarray information might be the way forward.