Sequencing

Sequencing refers to the techniques used to determine the primary structure of an unbranched biopolymer (DNA, RNA, protein, carbohydrate) resulting in a symbolic linear depiction of the monomeric subunits which summarizes much of the atomic-level structure of the molecule.

Latest Research and Reviews

  • Research |

    • Volkan Okur
    • , Megan T. Cho
    • , Richard van Wijk
    • , Brigitte van Oirschot
    • , Jonathan Picker
    • , Stephanie A. Coury
    • , Dorothy Grange
    • , Linda Manwaring
    • , Ian Krantz
    • , Colleen Clark Muraresku
    • , Peter J. Hulick
    • , Holley May
    • , Eric Pierce
    • , Emily Place
    • , Kinga Bujakowska
    • , Aida Telegrafi
    • , Ganka Douglas
    • , Kristin G. Monaghan
    • , Amber Begtrup
    • , Ashley Wilson
    • , Kyle Retterer
    • , Kwame Anyane-Yeboa
    •  & Wendy K. Chung
  • Research |

    This study presents the genomes of 2,101 emm28 Streptococcus pyogenes invasive strains, of which 492 were transcriptionally profiled, and 50 were assessed for virulence. GWAS, eQTL analysis, and study of isogenic mutant strains identified an intergenic region that alters global transcript profiles and bacterial virulence.

    • Priyanka Kachroo
    • , Jesus M. Eraso
    • , Stephen B. Beres
    • , Randall J. Olsen
    • , Luchang Zhu
    • , Waleed Nasser
    • , Paul E. Bernard
    • , Concepcion C. Cantu
    • , Matthew Ojeda Saavedra
    • , María José Arredondo
    • , Benjamin Strope
    • , Hackwon Do
    • , Muthiah Kumaraswami
    • , Jaana Vuopio
    • , Kirsi Gröndahl-Yli-Hannuksela
    • , Karl G. Kristinsson
    • , Magnus Gottfredsson
    • , Maiju Pesonen
    • , Johan Pensar
    • , Emily R. Davenport
    • , Andrew G. Clark
    • , Jukka Corander
    • , Dominique A. Caugant
    • , Shahin Gaini
    • , Marita Debess Magnussen
    • , Samantha L. Kubiak
    • , Hoang A. T. Nguyen
    • , S. Wesley Long
    • , Adeline R. Porter
    • , Frank R. DeLeo
    •  & James M. Musser
  • Research | | open

    Infection of a cell with influenza B virus (IBV) often results in cell death and the role of surviving cells in pathogenesis is unclear. Here, Dumm et al. generate a recombinant IBV that activates a host-cell reporter to permanently label infected cells, and show that surviving cells are important to preserve epithelial barrier function.

    • Rebekah E. Dumm
    • , Jessica K. Fiege
    • , Barbara M. Waring
    • , Chay T. Kuo
    • , Ryan A. Langlois
    •  & Nicholas S. Heaton

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