Featured
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Article |
A culture system to study oligodendrocyte myelination processes using engineered nanofibers
Primary rat oligodendocytes were cultured in the presence of electron-spun nanofibers of varying sizes as a model to study myelination processes in the mammalian central nervous system. The authors study the role of fiber diameter on the initiation of concentric wrapping by oligodendrocytes.
- Seonok Lee
- , Michelle K Leach
- & Jonah R Chan
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Research Highlights |
DNA nanoLEGOlogy
Researchers design a simple 'shake & bake' method for the assembly of complex nanostructures from interlocking DNA tiles.
- Petya V Krasteva
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Tools in Brief |
Assemble-on-a-chip
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Research Highlights |
Sorting out epigenetic states
A nanofluidic device can sort single DNA molecules based on their epigenetic marks.
- Tal Nawy
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Methods in Brief |
Gene expression regulation using nanohorns
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Research Highlights |
Controlling biology by radio
Radio waves and iron nanoparticles could hold the key to targeted perturbation of cells deep inside living tissue.
- Daniel Evanko
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Brief Communication |
A simple, versatile method for GFP-based super-resolution microscopy via nanobodies
Nanobodies that bind to fluorescent proteins with high affinity and are coupled to bright organic dyes allow simple efficient labeling of fusion proteins for super-resolution microscopy.
- Jonas Ries
- , Charlotte Kaplan
- & Helge Ewers
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Tools in Brief |
Nanocombinatorics for biology
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News & Views |
Close encounters: integrating nanopores and CMOS amplifiers for single-molecule detection
Using semiconductor processing to construct integrated circuits that reside close to nanopores, researchers demonstrate high-bandwidth, low-noise measurements of DNA translocation through solid-state nanopores.
- John S Oliver
- & Valentin Dimitrov
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Research Highlights |
A nanopore workhorse
Voltage-driven and enzyme-regulated control allows precise ratcheting of a DNA strand in and out of a nanopore.
- Nicole Rusk
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Research Highlights |
siRNA as a sponge
New nanostructure delivers potent dose of short interfering RNA
- Monya Baker
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Research Highlights |
A 'nano' era for electrophysiology
Researchers in three independent laboratories develop nanoscale devices for network-level electrophysiology.
- Erika Pastrana
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Article |
Integrated nanopore sensing platform with sub-microsecond temporal resolution
The temporal resolution of current signals from solid-state nanopores is improved by integrating a complementary metal-oxide-semiconductor preamplifier with the nanopores in thin silicon nitride membranes.
- Jacob K Rosenstein
- , Meni Wanunu
- & Kenneth L Shepard
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Tools in Brief |
Exploding nanodroplets
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Research Highlights |
Single-molecule circuits
An electronic circuit enables analysis of dynamic processivity of single molecules.
- Irene Kaganman
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Research Highlights |
A microscopic endoscope
Microscopic optical devices make their way into living cells.
- Daniel Evanko
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Research Highlights |
Nanoelectroporation
Precise amounts of DNA and quantum dots can be moved into cells through tiny channels.
- Monya Baker
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News in Brief |
Protein origami
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Research Highlights |
DNA origami in 3D
Complex, curved three-dimensional DNA nanostructures can be created using new DNA origami folding techniques.
- Allison Doerr
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Research Highlights |
One particle to rule them all?
Nanoparticles made of the natural pigment porphyrin combine desirable properties of both organic and inorganic particles.
- Natalie de Souza
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Research Highlights |
Nanopillars of light
Illuminating cells through tiny transparent pillars permits spatially confined excitation of fluorescent molecules.
- Natalie de Souza
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Editorial |
Into the fold
In spite of its promise, nanotechnology has seen little uptake among biologists. DNA origami may be able to avoid this fate.
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Technology Feature |
Screening: the age of fishes
Advances in microfluidics and imaging, combined with some high-profile studies, are increasing interest in whole-organism screening.
- Monya Baker
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Article |
A microfluidic array for large-scale ordering and orientation of embryos
A microfluidic embryo-trap array for large-scale end-on imaging of Drosophila melanogaster embryos permits quantitative analysis of dorsoventral gradients during development.
- Kwanghun Chung
- , Yoosik Kim
- & Hang Lu
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Technology Feature |
Nanotechnology imaging probes: smaller and more stable
Quantum dots, nanodiamonds and other nanomaterials broaden researchers' tools for watching biology.
- Monya Baker
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Research Highlights |
Reading cells from within
A nanoscale field-effect transistor with a three-dimensional probe-presentation design can record intracellular potentials from single cells.
- Erika Pastrana
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Brief Communication |
Spontaneous network activity visualized by ultrasensitive Ca2+ indicators, yellow Cameleon-Nano
Engineering of the Ca2+-sensing domain in existing yellow Cameleon Ca2+ indicators is used to create indicators with a range of increased Ca2+ affinities capable of detecting subtle changes in intracellular Ca2+ at low resting levels.
- Kazuki Horikawa
- , Yoshiyuki Yamada
- & Takeharu Nagai
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Research Highlights |
Polymers for protein detection
Nanotube arrays, imprinted with proteins, can be used as biosensors.
- Monya Baker
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Advertising Feature: Application Note |
Direct deposition of micro- and nanoscale hydrogels using Dip Pen Nanolithography (DPN)
- Paul L Stiles
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Research Highlights |
Robotics on the nanoscale
Nanoscale robots can be programmed to walk a DNA origami track.
- Allison Doerr
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Article |
Linking promoters to functional transcripts in small samples with nanoCAGE and CAGEscan
Capturing the 5′ end of transcripts from an input of only 1,000 cells and linking the transcription start sites to downstream sequences allows the analysis of complex transcriptome architecture.
- Charles Plessy
- , Nicolas Bertin
- & Piero Carninci
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Correspondence |
QuickPALM: 3D real-time photoactivation nanoscopy image processing in ImageJ
- Ricardo Henriques
- , Mickael Lelek
- & Musa M Mhlanga
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Technology Feature |
Clever PCR: more genotyping, smaller volumes
With microfluidics and multiplexing, researchers can get more information from PCR products in less time and with fewer reagents.
- Monya Baker
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Review Article |
Probing cellular events, one quantum dot at a time
- Fabien Pinaud
- , Samuel Clarke
- & Maxime Dahan
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Research Highlights |
Smart delivery with nanofactories
Researchers engineer biological 'nanofactories' that can trigger a quorum sensing response in bacteria.
- Allison Doerr
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Research Highlights |
Supporting actors
Two GFP-binding peptides, Enhancer and Minimizer, modulate GFP fluorescence and will enable a number of in vivo applications.
- Irene Kaganman
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News & Views |
Advancing neurochemical monitoring
Two new approaches to neurochemical monitoring in vivo—an improved real-time microsensor and genetically engineered cells that sense neurotransmitter levels—address the critical issue of brain reactivity to implanted devices.
- Paul A Garris