Featured
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Research Highlight |
Modeling multi-organ systems on a chip
To recapitulate some of the complexities of the human physiology, engineered tissues can be linked by vascular flow in a multi-organ chip.
- Nina Vogt
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Article |
Exosome detection via the ultrafast-isolation system: EXODUS
EXODUS is a high-speed isolation method for the enrichment of exosome from biological fluids with high purity and yield.
- Yuchao Chen
- , Qingfu Zhu
- & Fei Liu
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Review Article |
Acoustic tweezers for the life sciences
This review discusses and contrasts different acoustic-tweezer technologies and their applications in biology.
- Adem Ozcelik
- , Joseph Rufo
- & Tony Jun Huang
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Methods in Brief |
Freestyle fluidics
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Research Highlights |
A community repository for microfluidics
The Metafluidics initiative encourages researchers to upload and share open-source microfluidics designs.
- Tal Nawy
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Tools in Brief |
Microbial genomes on a chip
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Article |
Scalable whole-genome single-cell library preparation without preamplification
Direct library preparation (DLP) is a robust and economic method for preparing large numbers of single-cell whole-genome sequencing libraries without preamplification, to study copy-number heterogeneity at the cell level and other variant types at the clone or population level.
- Hans Zahn
- , Adi Steif
- & Carl L Hansen
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Research Highlights |
Coral-on-a-chip
A miniature platform for studying corals at microscale resolution sheds new light on their biology.
- Vesna Todorovic
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This Month |
Hasan DeMirci
The connection between snowboarding and getting more data from protein crystals.
- Vivien Marx
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Brief Communication |
Concentric-flow electrokinetic injector enables serial crystallography of ribosome and photosystem II
A concentric-flow microfluidic electrokinetic sample injector enables efficient delivery of microcrystals in their mother liquor for serial femtosecond X-ray crystallography with minimal sample consumption.
- Raymond G Sierra
- , Cornelius Gati
- & Hasan DeMirci
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Advertising Feature: Application Note |
Automated live cell imaging of cell migration across a microfluidic-controlled chemoattractant gradient
- Philip Lee
- , Cindy S Y Chen
- & Paul J Hung
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Methods in Brief |
Wireless pharmacology and optogenetics
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Methods in Brief |
Thousands of cell droplets
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Article |
A microfluidic device for label-free, physical capture of circulating tumor cell clusters
The Cluster-Chip provides highly efficient and gentle capture of circulating tumor cell clusters from milliliters of unprocessed whole blood, making it possible to study how these clusters contribute to metastasis.
- A Fatih Sarioglu
- , Nicola Aceto
- & Mehmet Toner
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News & Views |
Toward high-throughput biomechanical phenotyping of single molecules
Two high-throughput single-molecule force spectroscopy platforms expand the reach of this technology for biomechanical molecular phenotyping.
- David Alsteens
- , Savaş Tay
- & Daniel J Müller
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Technology Feature |
Biophysics: using sound to move cells
Moving and sorting cells with sound are a few of the possible applications for this no-contact technique.
- Vivien Marx
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Research Highlights |
Receptive cells feel the squeeze
Forcing cells through a small opening in a microfluidic channel lets foreign particles enter.
- Tal Nawy
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Technology Feature |
Screening: the age of fishes
Advances in microfluidics and imaging, combined with some high-profile studies, are increasing interest in whole-organism screening.
- Monya Baker
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Article |
A microfluidic array for large-scale ordering and orientation of embryos
A microfluidic embryo-trap array for large-scale end-on imaging of Drosophila melanogaster embryos permits quantitative analysis of dorsoventral gradients during development.
- Kwanghun Chung
- , Yoosik Kim
- & Hang Lu
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Technology Feature |
Clever PCR: more genotyping, smaller volumes
With microfluidics and multiplexing, researchers can get more information from PCR products in less time and with fewer reagents.
- Monya Baker
Geometric engineering of organoid culture for enhanced organogenesis in a dish
Multiomics sequencing goes spatial
Scott Manalis
Hang Lu