Research Highlight |
Featured
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Article |
Mass spectrometry imaging of untreated wet cell membranes in solution using single-layer graphene
Application of a single layer of graphene to untreated wet mammalian cells enables mass spectrometry imaging of cellular membranes of live cells in solution at subcellular resolution.
- Heejin Lim
- , Sun Young Lee
- & Dae Won Moon
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Research Highlights |
Single-molecule force analysis, unplugged
A nanoscopic force clamp enables high-throughput single-molecule analysis of DNA under tension without connection to a macroscopic instrument.
- Allison Doerr
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Methods in Brief |
Nanopores for multiplexed protein sensing
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Brief Communication |
Quantitative super-resolution imaging with qPAINT
Quantitative points accumulation in nanoscale topography (qPAINT) makes use of predictable binding kinetics between DNA-PAINT imager and docking strands to achieve accurate and precise counting of molecules in spatially unresolved complexes.
- Ralf Jungmann
- , Maier S Avendaño
- & Peng Yin
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Methods in Brief |
Designing protein-DNA nanowires
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Research Highlights |
From form to function
DNA building blocks that interact on the basis of shape rather than sequence assemble into highly dynamic and complex structures.
- Michael Eisenstein
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Brief Communication |
DNA nanoswitches: a quantitative platform for gel-based biomolecular interaction analysis
A DNA nanoswitch platform enables inexpensive kinetic and thermodynamic analysis of a range of biomolecular interactions using a simple gel electrophoresis readout.
- Mounir A Koussa
- , Ken Halvorsen
- & Wesley P Wong
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Article |
Spatial control of membrane receptor function using ligand nanocalipers
Ligand nanocalipers made using DNA nanotechnology are used to display ephrin-A5 at well-defined spatial intervals to study how nanoscale ligand spacing affects EphA2 receptor activation in breast cancer cells.
- Alan Shaw
- , Vanessa Lundin
- & Ana I Teixeira
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Article |
Enzymatic production of 'monoclonal stoichiometric' single-stranded DNA oligonucleotides
A method for enzymatically producing long, high-purity, single-stranded DNA oligonucleotides should find many applications in basic research, in DNA nanotechnology and in clinical fields.
- Cosimo Ducani
- , Corinna Kaul
- & Björn Högberg
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Methods in Brief |
Polypeptide nanostructures
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Article |
A culture system to study oligodendrocyte myelination processes using engineered nanofibers
Primary rat oligodendocytes were cultured in the presence of electron-spun nanofibers of varying sizes as a model to study myelination processes in the mammalian central nervous system. The authors study the role of fiber diameter on the initiation of concentric wrapping by oligodendrocytes.
- Seonok Lee
- , Michelle K Leach
- & Jonah R Chan
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Brief Communication |
A simple, versatile method for GFP-based super-resolution microscopy via nanobodies
Nanobodies that bind to fluorescent proteins with high affinity and are coupled to bright organic dyes allow simple efficient labeling of fusion proteins for super-resolution microscopy.
- Jonas Ries
- , Charlotte Kaplan
- & Helge Ewers
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Research Highlights |
siRNA as a sponge
New nanostructure delivers potent dose of short interfering RNA
- Monya Baker
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Research Highlights |
A 'nano' era for electrophysiology
Researchers in three independent laboratories develop nanoscale devices for network-level electrophysiology.
- Erika Pastrana
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News in Brief |
Protein origami
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Research Highlights |
DNA origami in 3D
Complex, curved three-dimensional DNA nanostructures can be created using new DNA origami folding techniques.
- Allison Doerr
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Research Highlights |
Nanopillars of light
Illuminating cells through tiny transparent pillars permits spatially confined excitation of fluorescent molecules.
- Natalie de Souza
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Editorial |
Into the fold
In spite of its promise, nanotechnology has seen little uptake among biologists. DNA origami may be able to avoid this fate.
A closer look at FluoroCubes