Medicinal chemistry

Definition

Medicinal chemistry deals with the design, optimization and development of chemical compounds for use as drugs. It is inherently a multidisciplinary topic — beginning with the synthesis of potential drugs followed by studies investigating their interactions with biological targets to understand the medicinal effects of the drug, its metabolism and side-effects.

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Latest Research and Reviews

  • Research |

    The use of a refined chemical library called the CeMM library of unique drugs (CLOUD) identified a synergistic interaction between flutamide and phenprocoumon in decreasing the growth of prostate cancer cells by regulating androgen receptor stability.

    • Marco P Licciardello
    • , Anna Ringler
    • , Patrick Markt
    • , Freya Klepsch
    • , Charles-Hugues Lardeau
    • , Sara Sdelci
    • , Erika Schirghuber
    • , André C Müller
    • , Michael Caldera
    • , Anja Wagner
    • , Rebecca Herzog
    • , Thomas Penz
    • , Michael Schuster
    • , Bernd Boidol
    • , Gerhard Dürnberger
    • , Yasin Folkvaljon
    • , Pär Stattin
    • , Vladimir Ivanov
    • , Jacques Colinge
    • , Christoph Bock
    • , Klaus Kratochwill
    • , Jörg Menche
    • , Keiryn L Bennett
    •  & Stefan Kubicek
  • Research | | open

    Targeting therapeutically-relevant proteins for degradation is an emerging paradigm in drug discovery. Here the authors describe a sensitive pulse SILAC mass spectrometry-based proteomics approach that reports global changes in protein stability following drug treatment in a single time point experiment.

    • Jian An
    • , Charles M. Ponthier
    • , Ragna Sack
    • , Jan Seebacher
    • , Michael B. Stadler
    • , Katherine A. Donovan
    •  & Eric S. Fischer
  • Research | | open

    There have been numerous attempts to develop nanomaterials to reach cells of the central nervous system for drug delivery. Here, the authors investigate the cellular fate of polymer-based nanoparticles with varying surface chemistries after administration directly into the brain.

    • Eric Song
    • , Alice Gaudin
    • , Amanda R. King
    • , Young-Eun Seo
    • , Hee-Won Suh
    • , Yang Deng
    • , Jiajia Cui
    • , Gregory T. Tietjen
    • , Anita Huttner
    •  & W. Mark Saltzman
  • Research | | open

    BET proteins bind chromatin through their bromodomains (BDs) to regulate transcription and chromatin remodelling. Here, the authors show that the BET protein Bdf1 is essential for the fungal pathogen Candida albicans, and report compounds that inhibit the Bdf1 BDs with high selectivity over human BDs.

    • Flore Mietton
    • , Elena Ferri
    • , Morgane Champleboux
    • , Ninon Zala
    • , Danièle Maubon
    • , Yingsheng Zhou
    • , Mike Harbut
    • , Didier Spittler
    • , Cécile Garnaud
    • , Marie Courçon
    • , Murielle Chauvel
    • , Christophe d’Enfert
    • , Boris A. Kashemirov
    • , Mitchell Hull
    • , Muriel Cornet
    • , Charles E. McKenna
    • , Jérôme Govin
    •  & Carlo Petosa

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