Chemical libraries

Definition

Chemical libraries are collections of molecules that are synthesized with the aim that they represent a given fraction of the theoretically possible chemical compounds that have yet been made. Research is focused on both the generation of libraries and on new methodology to screen them in the search for new or improved properties.

Latest Research and Reviews

  • Protocols |

    Titration of the optimal ratios of multicomponent biochemical reactions can be a laborious task. This protocol describes how to explore 10,000 combinations of concentrations of one to three reaction components with a droplet-based microfluidics platform.

    • Alexandre Baccouche
    • , Shu Okumura
    • , Rémi Sieskind
    • , Elia Henry
    • , Nathanaël Aubert-Kato
    • , Nicolas Bredeche
    • , Jean-François Bartolo
    • , Valérie Taly
    • , Yannick Rondelez
    • , Teruo Fujii
    •  & Anthony J Genot
    Nature Protocols 12, 1912–1932
  • Research | | open

    Encoded Library Technology (ELT) has streamlined the identification of chemical ligands for protein targets in drug discovery. Here, the authors optimize the ELT approach to screen multiple proteins in parallel and identify promising targets and antibacterial compounds for S. aureus, A. baumannii and M. tuberculosis.

    • Carl A. Machutta
    • , Christopher S. Kollmann
    • , Kenneth E. Lind
    • , Xiaopeng Bai
    • , Pan F. Chan
    • , Jianzhong Huang
    • , Lluis Ballell
    • , Svetlana Belyanskaya
    • , Gurdyal S. Besra
    • , David Barros-Aguirre
    • , Robert H. Bates
    • , Paolo A. Centrella
    • , Sandy S. Chang
    • , Jing Chai
    • , Anthony E. Choudhry
    • , Aaron Coffin
    • , Christopher P. Davie
    • , Hongfeng Deng
    • , Jianghe Deng
    • , Yun Ding
    • , Jason W. Dodson
    • , David T. Fosbenner
    • , Enoch N. Gao
    • , Taylor L. Graham
    • , Todd L. Graybill
    • , Karen Ingraham
    • , Walter P. Johnson
    • , Bryan W. King
    • , Christopher R. Kwiatkowski
    • , Joël Lelièvre
    • , Yue Li
    • , Xiaorong Liu
    • , Quinn Lu
    • , Ruth Lehr
    • , Alfonso Mendoza-Losana
    • , John Martin
    • , Lynn McCloskey
    • , Patti McCormick
    • , Heather P. O’Keefe
    • , Thomas O’Keeffe
    • , Christina Pao
    • , Christopher B. Phelps
    • , Hongwei Qi
    • , Keith Rafferty
    • , Genaro S. Scavello
    • , Matt S. Steiginga
    • , Flora S. Sundersingh
    • , Sharon M. Sweitzer
    • , Lawrence M. Szewczuk
    • , Amy Taylor
    • , May Fern Toh
    • , Juan Wang
    • , Minghui Wang
    • , Devan J. Wilkins
    • , Bing Xia
    • , Gang Yao
    • , Jean Zhang
    • , Jingye Zhou
    • , Christine P. Donahue
    • , Jeffrey A. Messer
    • , David Holmes
    • , Christopher C. Arico-Muendel
    • , Andrew J. Pope
    • , Jeffrey W. Gross
    •  & Ghotas Evindar
  • Research | | open

    Identification of inhibitors can be accelerated by using the target as a template for ligand formation. Here the authors show that DNA-functionalised magnetic nanoparticles guide templating of G-quadruplex binding c-MYC inhibitors from an array of building blocks, and can be isolated by magnetic decanting.

    • Deepanjan Panda
    • , Puja Saha
    • , Tania Das
    •  & Jyotirmayee Dash

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