Featured
-
-
Article
| Open AccessRole of reactive oxygen species in regulating 27-hydroxycholesterol-induced apoptosis of hematopoietic progenitor cells and myeloid cell lines
- Soo-Yeon Woo
- , Hansong Lee
- & Dongjun Lee
-
Article
| Open AccessZymosan-A promotes the regeneration of intestinal stem cells by upregulating ASCL2
- Jicong Du
- , Lan Fang
- & Cong Liu
-
Article
| Open AccessmTORC1 signaling pathway integrates estrogen and growth factor to coordinate vaginal epithelial cells proliferation and differentiation
- Shuo Wan
- , Yadong Sun
- & Meixiang Yang
-
Article
| Open AccessLoss of SNAI1 induces cellular plasticity in invasive triple-negative breast cancer cells
- Chrysoula Tsirigoti
- , Mohamad Moustafa Ali
- & Aristidis Moustakas
-
Article
| Open AccessHistocompatibility Minor 13 (HM13), targeted by miR-760, exerts oncogenic role in breast cancer by suppressing autophagy and activating PI3K-AKT-mTOR pathway
- Haiyan Yang
- , Zhi Li
- & Qiang Ding
-
Article
| Open AccessDirect conversion of human umbilical cord mesenchymal stem cells into retinal pigment epithelial cells for treatment of retinal degeneration
- Xiaoman Zhu
- , Zhiyang Chen
- & Haibin Tian
-
Article
| Open AccessIn vivo restoration of dystrophin expression in mdx mice using intra-muscular and intra-arterial injections of hydrogel microsphere carriers of exon skipping antisense oligonucleotides
- Shani Attias Cohen
- , Orit Bar-Am
- & Dror Seliktar
-
Article
| Open AccessModelling aggressive prostate cancers of young men in immune-competent mice, driven by isogenic Trp53 alterations and Pten loss
- Javier Octavio Mejía-Hernández
- , Simon P. Keam
- & Sue Haupt
-
Article
| Open AccessRegulator of calcineurin 1 deletion attenuates mitochondrial dysfunction and apoptosis in acute kidney injury through JNK/Mff signaling pathway
- Jing-Jie Xiao
- , Qing Liu
- & Bai-Fang Zhang
-
Article
| Open AccessInhibition of autophagy potentiates the cytotoxicity of the irreversible FGFR1-4 inhibitor FIIN-2 on lung adenocarcinoma
- Xiuqin Jia
- , Ming Xin
- & Jian Zhang
-
Article
| Open AccessTargeting proliferative retinopathy: Arginase 1 limits vitreoretinal neovascularization and promotes angiogenic repair
- Abdelrahman Y. Fouda
- , Zhimin Xu
- & Ruth B. Caldwell
-
Article
| Open AccessMulti-target action of β-alanine protects cerebellar tissue from ischemic damage
- Olga Kopach
- , Dmitri A. Rusakov
- & Sergiy Sylantyev
-
Article
| Open AccessActivation of pancreatic stellate cells attenuates intracellular Ca2+ signals due to downregulation of TRPA1 and protects against cell death induced by alcohol metabolites
- Agnieszka A. Kusiak
- , Monika A. Jakubowska
- & Pawel E. Ferdek
-
Article
| Open AccessZeb1 sustains hematopoietic stem cell functions by suppressing mitofusin-2-mediated mitochondrial fusion
- Kai Zhang
- , Huifang Zhao
- & Helen He Zhu
-
Article
| Open AccessAmmonium tetrathiomolybdate triggers autophagy-dependent NRF2 activation in vascular endothelial cells
- Mengling Zhang
- , Hongmei Qiu
- & Jun Zhang
-
Article
| Open AccessNovel 1-hydroxy phenothiazinium-based derivative protects against bacterial sepsis by inhibiting AAK1-mediated LPS internalization and caspase-11 signaling
- Chuang Yuan
- , Kelong Ai
- & Xinyu Yang
-
Article
| Open AccessThe dual action of glioma-derived exosomes on neuronal activity: synchronization and disruption of synchrony
- Renza Spelat
- , Nie Jihua
- & Vincent Torre
-
Article
| Open AccessGemcitabine resistance of pancreatic cancer cells is mediated by IGF1R dependent upregulation of CD44 expression and isoform switching
- Chen Chen
- , Shujie Zhao
- & James W. Freeman
-
Article
| Open AccessBET bromodomain inhibition rescues PD-1-mediated T-cell exhaustion in acute myeloid leukemia
- Mengjun Zhong
- , Rili Gao
- & Yangqiu Li
-
Article
| Open AccessHigh-content imaging of human hepatic spheroids for researching the mechanism of duloxetine-induced hepatotoxicity
- Juan Liu
- , Ruihong Li
- & Yunfang Wang
-
Article
| Open AccessInnovative multidimensional models in a high-throughput-format for different cell types of endocrine origin
- Stefan Bornstein
- , Igor Shapiro
- & Constanze Hantel
-
Article
| Open AccessTRAIL protects the immature lung from hyperoxic injury
- Tayyab Shahzad
- , Cho-Ming Chao
- & Harald Ehrhardt
-
Article
| Open AccessMitochondrial PKM2 deacetylation by procyanidin B2-induced SIRT3 upregulation alleviates lung ischemia/reperfusion injury
- Jing Zhao
- , Guorong Wang
- & Guangzhi Wang
-
Article
| Open AccessEllagic acid improves benign prostate hyperplasia by regulating androgen signaling and STAT3
- Woo Yong Park
- , Gahee Song
- & Jae-Young Um
-
Article
| Open AccessIdentification of an Epi-metabolic dependency on EHMT2/G9a in T-cell acute lymphoblastic leukemia
- Anna Montanaro
- , Samuel Kitara
- & Giovanni Roti
-
Article
| Open AccessHistone H3K27 demethylase UTX compromises articular chondrocyte anabolism and aggravates osteoarthritic degeneration
- Wei-Shiung Lian
- , Re-Wen Wu
- & Feng-Sheng Wang
-
Article
| Open AccessEstrogen and G protein-coupled estrogen receptor accelerate the progression of benign prostatic hyperplasia by inducing prostatic fibrosis
- Yang Yang
- , Jindong Sheng
- & Jie Jin
-
Article
| Open AccessHepatocyte Bcl-3 protects from death-receptor mediated apoptosis and subsequent acute liver failure
- Nadine Gehrke
- , Marcus A. Wörns
- & Jörn M. Schattenberg
-
Article
| Open AccessCharacterization of raloxifene as a potential pharmacological agent against SARS-CoV-2 and its variants
- Daniela Iaconis
- , Licia Bordi
- & Andrea R. Beccari
-
Article
| Open AccessDedifferentiation-mediated stem cell niche maintenance in early-stage ductal carcinoma in situ progression: insights from a multiscale modeling study
- Joseph D. Butner
- , Prashant Dogra
- & Zhihui Wang
-
Article
| Open AccessFASN promotes lymph node metastasis in cervical cancer via cholesterol reprogramming and lymphangiogenesis
- Qiqiao Du
- , Pan Liu
- & Shuzhong Yao
-
Article
| Open AccessSynovial mesenchymal progenitor derived aggrecan regulates cartilage homeostasis and endogenous repair capacity
- Roman J. Krawetz
- , Yiru Elizabeth Wu
- & Paul T. Salo
-
Article
| Open AccessInvolvement of FSP1-CoQ10-NADH and GSH-GPx-4 pathways in retinal pigment epithelium ferroptosis
- Ming Yang
- , Michelle Grace Tsui
- & Amy Cheuk Yin Lo
-
Article
| Open AccessTOPK/PBK is phosphorylated by ERK2 at serine 32, promotes tumorigenesis and is involved in sorafenib resistance in RCC
- Huimin Sun
- , Jianzhong Zheng
- & Chen Shao
-
Article
| Open AccessPOU6F1 cooperates with RORA to suppress the proliferation of lung adenocarcinoma by downregulating HIF1A signaling pathway
- Wenjing Xiao
- , Wei Geng
- & Yang Jin
-
Article
| Open AccessMEOX2-mediated regulation of Cathepsin S promotes cell proliferation and motility in glioma
- Ji Wang
- , Yanming Chen
- & Qing Lan
-
Article
| Open AccessB-cell lymphoma 6 alleviates nonalcoholic fatty liver disease in mice through suppression of fatty acid transporter CD36
- Hao Zhang
- , Yue Li
- & Jiahong Xia
-
Article
| Open AccessAge-related visual impairments and retinal ganglion cells axonal degeneration in a mouse model harboring OPTN (E50K) mutation
- Mingying Hou
- , Zhengbo Shao
- & Huiping Yuan
-
Article
| Open AccessTargeted CUL4A inhibition synergizes with cisplatin to yield long-term survival in models of head and neck squamous cell carcinoma through a DDB2-mediated mechanism
- Trace M. Jones
- , Claudia M. Espitia
- & Steffan T. Nawrocki
-
Article
| Open AccessMLKL deficiency in BrafV600EPten−/− melanoma model results in a modest delay of nevi development and reduced lymph node dissemination in male mice
- Sofie Martens
- , Nozomi Takahashi
- & Peter Vandenabeele
-
Article
| Open AccessAngiotensin II related glial cell activation and necroptosis of retinal ganglion cells after systemic hypotension in glaucoma
- Soo Ji Jeon
- , Jungbin Huh
- & Hae Young Lopilly Park
-
Article
| Open AccessHucMSC-derived exosomes delivered BECN1 induces ferroptosis of hepatic stellate cells via regulating the xCT/GPX4 axis
- Youwen Tan
- , Yan Huang
- & Yongmin Yan
-
Article
| Open AccessGut microbiota severely hampers the efficacy of NAD-lowering therapy in leukemia
- Oussama ElMokh
- , Saki Matsumoto
- & Michel A. Duchosal
-
Comment
| Open AccessSome mice lacking intrinsic, as well as death receptor induced apoptosis and necroptosis, can survive to adulthood
Programmed cell death, in particular the intrinsic apoptotic pathway, has been shown to play a critical role in the shaping of tissues during embryonic development. The multi-BCL-2 Homology (BH) domain effectors of apoptosis, BAX, BAK, and BOK, are essential for cell killing in the intrinsic apoptotic pathway. It was therefore surprising that we found earlier that a few mice lacking all effectors of apoptosis (Bax;Bak;Bok triple knockout), albeit many fewer than expected based on Mendelian ratios, could reach weaning or even adulthood. This indicated that death receptor induced apoptosis or necroptosis, a lytic form of programmed cell death, may also have roles in embryogenesis alongside the intrinsic apoptotic pathway. To explore this, we generated Bax;Bak;Bok;caspase-8;Mlkl quintuple knockout mice, which lack not only intrinsic apoptosis but also death receptor induced apoptosis (loss of caspase-8) and necroptosis (loss of MLKL). These foetuses exhibited similar defects to the Bax;Bak;Bok triple knockout mice and, intriguingly, a small number of Bax;Bak;Bok;caspase-8;Mlkl quintuple knockout mice could reach weaning or even adulthood. These findings identify the contributions of these three programmed cell death pathways to embryonic development and show that despite the absence of all of them, development to adulthood is possible, albeit very rare.
- Francine F. S. Ke
- , Kerstin Brinkmann
- & Andreas Strasser
-
Article
| Open AccessRBMS1 promotes gastric cancer metastasis through autocrine IL-6/JAK2/STAT3 signaling
- Mengyuan Liu
- , Heming Li
- & Lu Xu
-
Article
| Open AccessOsimertinib and anti-HER3 combination therapy engages immune dependent tumor toxicity via STING activation in trans
- J. M. Vicencio
- , R. Evans
- & T. Ng
-
Article
| Open AccessLPS/Bcl3/YAP1 signaling promotes Sox9+HNF4α+ hepatocyte-mediated liver regeneration after hepatectomy
- Changchun Shao
- , Yingying Jing
- & Lixin Wei
-
Article
| Open AccessMesenchymal stem cells protect against ferroptosis via exosome-mediated stabilization of SLC7A11 in acute liver injury
Schematic diagram of the protective effect of MSC-derived exosomes on maintaining SLC7A11 function during ferroptosis involved in CCl4-induced ALI.
- Feiyan Lin
- , Wenyi Chen
- & Hongcui Cao
-
Review Article
| Open AccessTherapeutic approaches targeting CD95L/CD95 signaling in cancer and autoimmune diseases
- Vesna Risso
- , Elodie Lafont
- & Matthieu Le Gallo