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Caspase 8 deletion causes infection/inflammation-induced bone marrow failure and MDS-like disease in mice
- Shanhui Liu
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Meeting Report
| Open Access11th international multithematic scientific biomedical congress (IMBMC), Nicosia, Cyprus, 2023
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FBXL8 inhibits post-myocardial infarction cardiac fibrosis by targeting Snail1 for ubiquitin-proteasome degradation
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RUVBL1 ubiquitination by DTL promotes RUVBL1/2-β-catenin-mediated transcriptional regulation of NHEJ pathway and enhances radiation resistance in breast cancer
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The broad impact of cell death genes on the human disease phenome
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Genetic and pharmacological reduction of CDK14 mitigates synucleinopathy
- Jean-Louis A. Parmasad
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TRIB3 promotes the progression of renal cell carcinoma by upregulating the lipid droplet-associated protein PLIN2
- Jun Li
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Meeting Report
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The 10th Barossa meeting: Cell Signalling to Cancer Medicine
- Winnie L. Kan
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Disrupting pro-survival and inflammatory pathways with dimethyl fumarate sensitizes chronic lymphocytic leukemia to cell death
- Maria Elena Mantione
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Deficiency of skeletal muscle Agrin contributes to the pathogenesis of age-related sarcopenia in mice
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Review Article
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Isoform alterations in the ubiquitination machinery impacting gastrointestinal malignancies
- Srimathi Kasturirangan
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Article
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Synergistic antitumor activity between HER2 antibody-drug conjugate and chemotherapy for treating advanced colorectal cancer
- Hongfu Liu
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GITRL impairs hepatocyte repopulation by liver progenitor cells to aggravate inflammation and fibrosis by GITR+CD8+ T lymphocytes in CDE Mice
- Li Li
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Glucocorticoid stress hormones stimulate vesicle-free Tau secretion and spreading in the brain
- Qing Yu
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Dietary long-chain fatty acids promote colitis by regulating palmitoylation of STAT3 through CD36-mediated endocytosis
- Yuping Wei
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The heterogeneity of signaling pathways and drug responses in intrahepatic cholangiocarcinoma with distinct genetic mutations
- Yangyang Feng
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Amyloid aggregates induced by the p53-R280T mutation lead to loss of p53 function in nasopharyngeal carcinoma
- Jingzhi Li
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E3 ligase TRIM65 alleviates intestinal ischemia/reperfusion injury through inhibition of TOX4-mediated apoptosis
- Yingjie Huang
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Death receptor 5 is required for intestinal stem cell activity during intestinal epithelial renewal at homoeostasis
- Jianbo Liu
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CRABP2 affects chemotherapy resistance of ovarian cancer by regulating the expression of HIF1α
- Xin Fu
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Targeting NEDD8 suppresses surgical stress-facilitated metastasis of colon cancer via restraining regulatory T cells
- Yi Jiang
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RNF115/BCA2 deficiency alleviated acute liver injury in mice by promoting autophagy and inhibiting inflammatory response
- Jinqiu Feng
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Imatinib induces ferroptosis in gastrointestinal stromal tumors by promoting STUB1-mediated GPX4 ubiquitination
- Xiangfei Sun
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Single-cell transcriptional landscape of long non-coding RNAs orchestrating mouse heart development
- Thaís A. R. Ramos
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Activation of GPER1 in macrophages ameliorates UUO-induced renal fibrosis
- Lin Xie
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The aryl hydrocarbon receptor controls mesenchymal stromal cell-mediated immunomodulation via ubiquitination of eukaryotic elongation factor-2 kinase
- Enkhmaa Lkhagva-Yondon
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The C-type lectin COLEC10 is predominantly produced by hepatic stellate cells and involved in the pathogenesis of liver fibrosis
- Mengfan Zhang
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Ferroptosis sensitization in glioma: exploring the regulatory mechanism of SOAT1 and its therapeutic implications
- Shicheng Sun
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UBE4B interacts with the ITCH E3 ubiquitin ligase to induce Ku70 and c-FLIPL polyubiquitination and enhanced neuroblastoma apoptosis
- Christophe Le Clorennec
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Review Article
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Mesenchymal stem cells under epigenetic control – the role of epigenetic machinery in fate decision and functional properties
- Alicja Walewska
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SAA suppresses α-PD-1 induced anti-tumor immunity by driving TH2 polarization in lung adenocarcinoma
- Xin Wang
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Salicylate induces AMPK and inhibits c-MYC to activate a NRF2/ARE/miR-34a/b/c cascade resulting in suppression of colorectal cancer metastasis
- Chunfeng Liu
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Review Article
| Open Access
Macrophage polarization and metabolism in atherosclerosis
- Pengbo Hou
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Article
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Inherited myogenic abilities in muscle precursor cells defined by the mitochondrial complex I-encoding protein
- Norio Motohashi
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LAIR1 drives glioma progression by nuclear focal adhesion kinase dependent expressions of cyclin D1 and immunosuppressive chemokines/cytokines
- Xiaoqian Wei
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A new scaffold-free tumoroid model provides a robust preclinical tool to investigate invasion and drug response in Renal Cell Carcinoma
- Irinka Séraudie
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Hepatic T-cell senescence and exhaustion are implicated in the progression of fatty liver disease in patients with type 2 diabetes and mouse model with nonalcoholic steatohepatitis
- Byeong Chang Sim
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Inhibition of cGAS–STING pathway alleviates neuroinflammation-induced retinal ganglion cell death after ischemia/reperfusion injury
- Xingdi Wu
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- & Kaijun Wang
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Article
| Open Access
Minnelide combined with anti-ANGPTL3-FLD monoclonal antibody completely protects mice with adriamycin nephropathy by promoting autophagy and inhibiting apoptosis
- Baowei Ji
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- & Jian Yu
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Article
| Open Access
A small molecule 20C from Gastrodia elata inhibits α-synuclein aggregation and prevents progression of Parkinson’s disease
- Ye Peng
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Article
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NPM promotes hepatotoxin-induced fibrosis by inhibiting ROS-induced apoptosis of hepatic stellate cells and upregulating lncMIAT-induced TGF-β2
- Xue Ding
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Article
| Open Access
Nuclear localization of TET2 requires β-catenin activation and correlates with favourable prognosis in colorectal cancer
- Changpeng Li
- , Jingcai He
- & Hui Zheng
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Article
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HSF-1/miR-145-5p transcriptional axis enhances hyperthermic intraperitoneal chemotherapy efficacy on peritoneal ovarian carcinosis
- Silvia Di Agostino
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- & Giovanni Blandino
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Article
| Open Access
p53 isoform expression promotes a stemness phenotype and inhibits doxorubicin sensitivity in breast cancer
- Luiza Steffens Reinhardt
- , Kira Groen
- & Kelly A. Avery-Kiejda
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Article
| Open Access
Histone acetylation by HBO1 (KAT7) activates Wnt/β-catenin signaling to promote leukemogenesis in B-cell acute lymphoblastic leukemia
- Hao Wang
- , Yingqi Qiu
- & Yuhua Li
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Article
| Open Access
FDW028, a novel FUT8 inhibitor, impels lysosomal proteolysis of B7-H3 via chaperone-mediated autophagy pathway and exhibits potent efficacy against metastatic colorectal cancer
- Mengmeng Wang
- , Zhoudong Zhang
- & Weipeng Wang
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Article
| Open Access
Inhibition of autotaxin alleviates pathological features of hepatic encephalopathy at the level of gut–liver–brain axis: an experimental and bioinformatic study
- Ali Sepehrinezhad
- , Ali Shahbazi
- & Sajad Sahab Negah
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Article
| Open Access
DEF6(differentially exprehomolog) exacerbates pathological cardiac hypertrophy via RAC1
- Yan Sun
- , Changlu Xu
- & Xi Jiang
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Article
| Open Access
Loss of TP53 cooperates with c-MET overexpression to drive hepatocarcinogenesis
- Yi Zhou
- , Guofei Cui
- & Haichuan Wang
Trauma-associated extracellular histones mediate inflammation via a MYD88-IRAK1-ERK signaling axis and induce lytic cell death in human adipocytes