Preclinical research articles within Cell Death & Disease

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• Article
  11 May 2024 | Open Access

  Valrubicin-loaded immunoliposomes for specific vesicle-mediated cell death in the treatment of hematological cancers

  • Aleksandra Georgievski
  • , Pierre-Simon Bellaye
  •  & Ronan Quéré

• Article
  23 April 2024 | Open Access

  Trauma-associated extracellular histones mediate inflammation via a MYD88-IRAK1-ERK signaling axis and induce lytic cell death in human adipocytes

  • Julian Roos
  • , Julia Zinngrebe
  •  & Pamela Fischer-Posovszky

• Article
  04 April 2024 | Open Access

  Genetic and pharmacological reduction of CDK14 mitigates synucleinopathy

  • Jean-Louis A. Parmasad
  • , Konrad M. Ricke
  •  & Maxime W. C. Rousseaux

• Meeting Report
  21 March 2024 | Open Access

  The 10^th Barossa meeting: Cell Signalling to Cancer Medicine

  • Winnie L. Kan
  • , Barbara J. McClure
  •  & Jason A. Powell

• Article
  18 March 2024 | Open Access

  Disrupting pro-survival and inflammatory pathways with dimethyl fumarate sensitizes chronic lymphocytic leukemia to cell death

  • Maria Elena Mantione
  • , Miriam Meloni
  •  & Marta Muzio

• Article
  05 March 2024 | Open Access

  Synergistic antitumor activity between HER2 antibody-drug conjugate and chemotherapy for treating advanced colorectal cancer

  • Hongfu Liu
  • , Dongdong Zhou
  •  & Shuyong Zhang

• Article
  13 November 2023 | Open Access

  UBE4B interacts with the ITCH E3 ubiquitin ligase to induce Ku70 and c-FLIPL polyubiquitination and enhanced neuroblastoma apoptosis

  • Christophe Le Clorennec
  • , Divya Subramonian
  •  & Peter E. Zage

• Article
  09 September 2023 | Open Access

  Minnelide combined with anti-ANGPTL3-FLD monoclonal antibody completely protects mice with adriamycin nephropathy by promoting autophagy and inhibiting apoptosis

  • Baowei Ji
  • , Junchao Liu
  •  & Jian Yu

• Article
  08 August 2023 | Open Access

  p53 isoform expression promotes a stemness phenotype and inhibits doxorubicin sensitivity in breast cancer

  • Luiza Steffens Reinhardt
  • , Kira Groen
  •  & Kelly A. Avery-Kiejda

• Article
  04 August 2023 | Open Access

  Histone acetylation by HBO1 (KAT7) activates Wnt/β-catenin signaling to promote leukemogenesis in B-cell acute lymphoblastic leukemia

  • Hao Wang
  • , Yingqi Qiu
  •  & Yuhua Li

• Article
  07 July 2023 | Open Access

  A novel CTLA-4 blocking strategy based on nanobody enhances the activity of dendritic cell vaccine-stimulated antitumor cytotoxic T lymphocytes

  • Wenli Yang
  • , Yanyang Pang
  •  & Wu Wang

• Article
  24 May 2023 | Open Access

  Activation of HIF-1α C-terminal transactivation domain protects against hypoxia-induced kidney injury through hexokinase 2-mediated mitophagy

  • Zuo-Lin Li
  • , Lin Ding
  •  & Bi-Cheng Liu

• Article
  23 May 2023 | Open Access

  Whey-based diet containing medium chain triglycerides modulates the gut microbiota and protects the intestinal mucosa from chemotherapy while maintaining therapy efficacy

  • Hannah R. Wardill
  • , Ana Rita Da Silva Ferreira
  •  & Wim J. E. Tissing

• Review Article
  12 May 2023 | Open Access

  Nitroglycerin: a comprehensive review in cancer therapy

  • Mélina Meunier
  • , Aline Yammine
  •  & Stéphanie Plenchette

• Article
  09 May 2023 | Open Access

  Inhibition of extranodal NK/T-cell lymphoma by Chiauranib through an AIF-dependent pathway and its synergy with L-asparaginase

  • Tianxiao Gao
  • , Jieye Huang
  •  & Zhiming Li

• Article
  04 May 2023 | Open Access

  Radiation therapy improves CAR T cell activity in acute lymphoblastic leukemia

  • Mayumi Sugita
  • , Takahiro Yamazaki
  •  & Monica L. Guzman

• Article
  29 April 2023 | Open Access

  Therapeutic efficacy of a MMAE-based anti-DR5 drug conjugate Oba01 in preclinical models of pancreatic cancer

  • Chao Zheng
  • , Dongdong Zhou
  •  & Shuyong Zhang

• Article
  28 March 2023 | Open Access

  Mitochondria-derived H₂O₂ triggers liver regeneration via FoxO3a signaling pathway after partial hepatectomy in mice

  • Hua Bai
  • , Cong-Wen Fang
  •  & Xu-Jun Qin

• Article
  25 February 2023 | Open Access

  DAPL1 prevents epithelial–mesenchymal transition in the retinal pigment epithelium and experimental proliferative vitreoretinopathy

  • Xiaoyin Ma
  • , Shuxian Han
  •  & Ling Hou

• Review Article
  16 February 2023 | Open Access

  Glutathione system enhancement for cardiac protection: pharmacological options against oxidative stress and ferroptosis

  • Mingyue Tan
  • , Yunfei Yin
  •  & Hongxia Li

• Article
  21 December 2022 | Open Access

  DC vaccines loaded with glioma cells killed by photodynamic therapy induce Th17 anti-tumor immunity and provide a four-gene signature for glioma prognosis

  • Maria Vedunova
  • , Victoria Turubanova
  •  & Dmitri V. Krysko

• Article
  19 December 2022 | Open Access

  Glucocorticoid-induced microRNA-378 signaling mediates the progression of pancreatic cancer by enhancing autophagy

  • Li Liu
  • , Shanshan Han
  •  & Ingrid Herr

• Article
  01 December 2022 | Open Access

  Valosin-containing protein (VCP/p97) inhibition reduces viral clearance and induces toxicity associated with muscular damage

  • Marta del Rio Oliva
  •  & Michael Basler

• Article
  19 November 2022 | Open Access

  PRDM15 interacts with DNA-PK-Ku complex to promote radioresistance in rectal cancer by facilitating DNA damage repair

  • Yue Yu
  • , Tingting Liu
  •  & Wei Zhang

• Article
  04 November 2022 | Open Access

  EGFR-induced suppression of HPV E6/E7 is mediated by microRNA-9-5p silencing of BRD4 protein in HPV-positive head and neck squamous cell carcinoma

  • Danupon Nantajit
  • , Luana Presta
  •  & Mahvash Tavassoli

• Article
  28 September 2022 | Open Access

  Loss of SNAI1 induces cellular plasticity in invasive triple-negative breast cancer cells

  • Chrysoula Tsirigoti
  • , Mohamad Moustafa Ali
  •  & Aristidis Moustakas

• Article
  09 September 2022 | Open Access

  In vivo restoration of dystrophin expression in mdx mice using intra-muscular and intra-arterial injections of hydrogel microsphere carriers of exon skipping antisense oligonucleotides

  • Shani Attias Cohen
  • , Orit Bar-Am
  •  & Dror Seliktar

• Article
  30 August 2022 | Open Access

  Inhibition of autophagy potentiates the cytotoxicity of the irreversible FGFR1-4 inhibitor FIIN-2 on lung adenocarcinoma

  • Xiuqin Jia
  • , Ming Xin
  •  & Jian Zhang

• Article
  29 August 2022 | Open Access

  Targeting proliferative retinopathy: Arginase 1 limits vitreoretinal neovascularization and promotes angiogenic repair

  • Abdelrahman Y. Fouda
  • , Zhimin Xu
  •  & Ruth B. Caldwell

• Article
  29 August 2022 | Open Access

  Activation of pancreatic stellate cells attenuates intracellular Ca²⁺ signals due to downregulation of TRPA1 and protects against cell death induced by alcohol metabolites

  • Agnieszka A. Kusiak
  • , Monika A. Jakubowska
  •  & Pawel E. Ferdek

• Article
  13 August 2022 | Open Access

  The dual action of glioma-derived exosomes on neuronal activity: synchronization and disruption of synchrony

  • Renza Spelat
  • , Nie Jihua
  •  & Vincent Torre

• Article
  02 August 2022 | Open Access

  BET bromodomain inhibition rescues PD-1-mediated T-cell exhaustion in acute myeloid leukemia

  • Mengjun Zhong
  • , Rili Gao
  •  & Yangqiu Li

• Article
  07 June 2022 | Open Access

  Estrogen and G protein-coupled estrogen receptor accelerate the progression of benign prostatic hyperplasia by inducing prostatic fibrosis

  • Yang Yang
  • , Jindong Sheng
  •  & Jie Jin

• Article
  31 May 2022 | Open Access

  Hepatocyte Bcl-3 protects from death-receptor mediated apoptosis and subsequent acute liver failure

  • Nadine Gehrke
  • , Marcus A. Wörns
  •  & Jörn M. Schattenberg

• Article
  25 May 2022 | Open Access

  Characterization of raloxifene as a potential pharmacological agent against SARS-CoV-2 and its variants

  • Daniela Iaconis
  • , Licia Bordi
  •  & Andrea R. Beccari

• Article
  18 April 2022 | Open Access

  MEOX2-mediated regulation of Cathepsin S promotes cell proliferation and motility in glioma

  • Ji Wang
  • , Yanming Chen
  •  & Qing Lan

• Article
  15 April 2022 | Open Access

  Targeted CUL4A inhibition synergizes with cisplatin to yield long-term survival in models of head and neck squamous cell carcinoma through a DDB2-mediated mechanism

  • Trace M. Jones
  • , Claudia M. Espitia
  •  & Steffan T. Nawrocki

• Article
  28 March 2022 | Open Access

  Osimertinib and anti-HER3 combination therapy engages immune dependent tumor toxicity via STING activation in trans

  • J. M. Vicencio
  • , R. Evans
  •  & T. Ng

• Article
  24 January 2022 | Open Access

  Glucose-regulated protein 78 modulates cell growth, epithelial–mesenchymal transition, and oxidative stress in the hyperplastic prostate

  • Xun Fu
  • , Jianmin Liu
  •  & Xinhua Zhang

• Article
  17 January 2022 | Open Access

  Blocking autophagy overcomes resistance to dual histone deacetylase and proteasome inhibition in gynecologic cancer

  • Jianling Bi
  • , Yuping Zhang
  •  & Kimberly K. Leslie

• Article
  20 December 2021 | Open Access

  NLPR3 inflammasome inhibition alleviates hypoxic endothelial cell death in vitro and protects blood–brain barrier integrity in murine stroke

  • Maximilian Bellut
  • , Lena Papp
  •  & Michael K. Schuhmann

• Article
  08 October 2021 | Open Access

  TDAG51 induces renal interstitial fibrosis through modulation of TGF-β receptor 1 in chronic kidney disease

  • Rachel E. Carlisle
  • , Zahraa Mohammed-Ali
  •  & Jeffrey G. Dickhout

• Article
  30 September 2021 | Open Access

  Modulation of oxidative phosphorylation augments antineoplastic activity of mitotic aurora kinase inhibition

  • Zijian Zhang
  • , Deshun Zeng
  •  & Zifeng Wang

• Article
  25 September 2021 | Open Access

  Combination of tyrosine kinase inhibitors and the MCL1 inhibitor S63845 exerts synergistic antitumorigenic effects on CML cells

  • Alena Malyukova
  • , Dorina Ujvari
  •  & Daniel Salamon

• Article
  08 September 2021 | Open Access

  CISD3 inhibition drives cystine-deprivation induced ferroptosis

  • Yanchun Li
  • , Xin Wang
  •  & Ying Wang

• Article
  06 August 2021 | Open Access

  Caspase-8 mutations associated with head and neck cancer differentially retain functional properties related to TRAIL-induced apoptosis and cytokine induction

  • Zhibin Cui
  • , Hadas Dabas
  •  & Daniel E. Johnson

• Article
  15 July 2021 | Open Access

  DHA exhibits synergistic therapeutic efficacy with cisplatin to induce ferroptosis in pancreatic ductal adenocarcinoma via modulation of iron metabolism

  • Jing Du
  • , Xu Wang
  •  & Ying Wang

• Article
  05 July 2021 | Open Access

  Operative ubiquitin-specific protease 22 deubiquitination confers a more invasive phenotype to cholangiocarcinoma

  • Yu Tian
  • , Bo Tang
  •  & Liming Wang

• Article
  23 June 2021 | Open Access

  Clinical stage drugs targeting inhibitor of apoptosis proteins purge episomal Hepatitis B viral genome in preclinical models

  • Michelle P. Clark
  • , Thao Huynh
  •  & Gregor Ebert

• Article
  20 May 2021 | Open Access

  Let-7f miRNA regulates SDF-1α- and hypoxia-promoted migration of mesenchymal stem cells and attenuates mammary tumor growth upon exosomal release

  • Virginia Egea
  • , Kai Kessenbrock
  •  & Christian Ries