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| Open AccessConcurrent inhibition of pBADS99 synergistically improves MEK inhibitor efficacy in KRASG12D-mutant pancreatic ductal adenocarcinoma
- Yan Qin Tan
- , Bowen Sun
- & Vijay Pandey
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Article
| Open AccessPRMT1-mediated PGK1 arginine methylation promotes colorectal cancer glycolysis and tumorigenesis
- Hao Liu
- , Xintian Chen
- & Xiangyang Yu
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Article
| Open AccessCRABP2 affects chemotherapy resistance of ovarian cancer by regulating the expression of HIF1α
- Xin Fu
- , Qian Zhang
- & Qiuping Dong
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Article
| Open AccessCharacterizing influence of rCHOP treatment on diffuse large B-cell lymphoma microenvironment through in vitro microfluidic spheroid model
- Matthew R. Sullivan
- , Rachel P. White
- & Tania Konry
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Article
| Open AccessTargeting the E2F1/Rb/HDAC1 axis with the small molecule HR488B effectively inhibits colorectal cancer growth
- Namin Duan
- , Xiaohui Hu
- & Ning Liu
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Article
| Open AccessTargeting protein methylation in pancreatic cancer cells results in KRAS signaling imbalance and inhibition of autophagy
- María F. Montenegro
- , Román Martí-Díaz
- & José Neptuno Rodríguez-López
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Article
| Open AccessTargeting cis-regulatory elements of FOXO family is a novel therapeutic strategy for induction of leukemia cell differentiation
- Kenta Kurayoshi
- , Yusuke Takase
- & Atsushi Hirao
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Article
| Open AccessA small molecule 20C from Gastrodia elata inhibits α-synuclein aggregation and prevents progression of Parkinson’s disease
- Ye Peng
- , Jun-rui Ye
- & Nai-hong Chen
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Article
| Open AccessFDW028, a novel FUT8 inhibitor, impels lysosomal proteolysis of B7-H3 via chaperone-mediated autophagy pathway and exhibits potent efficacy against metastatic colorectal cancer
- Mengmeng Wang
- , Zhoudong Zhang
- & Weipeng Wang
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Article
| Open AccessInhibition of TRPV4 remodels single cell polarity and suppresses the metastasis of hepatocellular carcinoma
- Jian Liu
- , Yongjian Guo
- & Libin Wei
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Article
| Open AccessDiscovery of an OTUD3 inhibitor for the treatment of non-small cell lung cancer
- Yonghui Zhang
- , Tongde Du
- & Peiyu Li
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Article
| Open AccessPost-transcriptional modification of m6A methylase METTL3 regulates ERK-induced androgen-deprived treatment resistance prostate cancer
- Yang Li
- , Shimiao Zhu
- & Zhiqun Shang
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Article
| Open AccessFatostatin induces ferroptosis through inhibition of the AKT/mTORC1/GPX4 signaling pathway in glioblastoma
- Jiayang Cai
- , Zhang Ye
- & Qianxue Chen
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Article
| Open AccessSupplementation with α-ketoglutarate improved the efficacy of anti-PD1 melanoma treatment through epigenetic modulation of PD-L1
- Nian Liu
- , Jianglin Zhang
- & Cong Peng
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Article
| Open AccessCiclopirox drives growth arrest and autophagic cell death through STAT3 in gastric cancer cells
- Lingyan Chen
- , Dejian Chen
- & Bin Lu
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Article
| Open AccessGenuine selective caspase-2 inhibition with new irreversible small peptidomimetics
- Elodie Bosc
- , Julie Anastasie
- & Etienne D. Jacotot
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Article
| Open AccessSR9009 inhibits lethal prostate cancer subtype 1 by regulating the LXRα/FOXM1 pathway independently of REV-ERBs
- Hang Xu
- , Jiapeng Zhang
- & Lu Yang
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Article
| Open AccessThe mycotoxin viriditoxin induces leukemia- and lymphoma-specific apoptosis by targeting mitochondrial metabolism
- Fabian Stuhldreier
- , Laura Schmitt
- & Sebastian Wesselborg
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Editorial
| Open AccessHigh-potency PD-1/PD-L1 degradation induced by Peptide-PROTAC in human cancer cells
- Meng-Yuan Dai
- , Yu-Ying Shi
- & Hong-Bing Cai
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Article
| Open AccessZymosan-A promotes the regeneration of intestinal stem cells by upregulating ASCL2
- Jicong Du
- , Lan Fang
- & Cong Liu
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Article
| Open AccessAmmonium tetrathiomolybdate triggers autophagy-dependent NRF2 activation in vascular endothelial cells
- Mengling Zhang
- , Hongmei Qiu
- & Jun Zhang
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Article
| Open AccessNovel 1-hydroxy phenothiazinium-based derivative protects against bacterial sepsis by inhibiting AAK1-mediated LPS internalization and caspase-11 signaling
- Chuang Yuan
- , Kelong Ai
- & Xinyu Yang
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Article
| Open AccessGemcitabine resistance of pancreatic cancer cells is mediated by IGF1R dependent upregulation of CD44 expression and isoform switching
- Chen Chen
- , Shujie Zhao
- & James W. Freeman
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Article
| Open AccessLomitapide, a cholesterol-lowering drug, is an anticancer agent that induces autophagic cell death via inhibiting mTOR
- Boah Lee
- , Seung Ju Park
- & Seyun Kim
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Article
| Open AccessStabilization of SAMHD1 by NONO is crucial for Ara-C resistance in AML
- Feifei Zhang
- , Jun Sun
- & Xiao-Bin Lv
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Article
| Open AccessHsp90 induces Acsl4-dependent glioma ferroptosis via dephosphorylating Ser637 at Drp1
- Zong Miao
- , Wei Tian
- & Jing Ji
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Article
| Open AccessDisruption of β-catenin-mediated negative feedback reinforces cAMP-induced neuronal differentiation in glioma stem cells
- Zhijie Chen
- , Yingqian Zhong
- & Ke Sai
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Article
| Open AccessGut microbiota severely hampers the efficacy of NAD-lowering therapy in leukemia
- Oussama ElMokh
- , Saki Matsumoto
- & Michel A. Duchosal
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Review Article
| Open AccessTherapeutic approaches targeting CD95L/CD95 signaling in cancer and autoimmune diseases
- Vesna Risso
- , Elodie Lafont
- & Matthieu Le Gallo
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Article
| Open AccessPlasma-activated medium induces ferroptosis by depleting FSP1 in human lung cancer cells
- Ara Jo
- , Jin Hee Bae
- & Jin Woong Chung
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Article
| Open AccessTargeting autophagy peptidase ATG4B with a novel natural product inhibitor Azalomycin F4a for advanced gastric cancer
- Lin Zhong
- , Bin Yang
- & Junjian Wang
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Article
| Open AccessExosome-mediated miR-7-5p delivery enhances the anticancer effect of Everolimus via blocking MNK/eIF4E axis in non-small cell lung cancer
- Sile Liu
- , Weiyuan Wang
- & Songqing Fan
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Article
| Open AccessPHY34 inhibits autophagy through V-ATPase V0A2 subunit inhibition and CAS/CSE1L nuclear cargo trafficking in high grade serous ovarian cancer
- Amrita Salvi
- , Alexandria N. Young
- & Joanna E. Burdette
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Article
| Open AccessApatinib inhibits glioma cell malignancy in patient-derived orthotopic xenograft mouse model by targeting thrombospondin 1/myosin heavy chain 9 axis
- Hui Yao
- , Jiangang Liu
- & Yulun Huang
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Article
| Open AccessAlpelisib combination treatment as novel targeted therapy against hepatocellular carcinoma
- Hongwei Xu
- , Kefei Chen
- & Xin Chen
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Article
| Open AccessSelective degradation of AR-V7 to overcome castration resistance of prostate cancer
- Yuan Liu
- , Cuifu Yu
- & Hongbiao Huang
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Article
| Open AccessImmunomodulatory effect of NEDD8-activating enzyme inhibition in Multiple Myeloma: upregulation of NKG2D ligands and sensitization to Natural Killer cell recognition
- Sara Petillo
- , Cristina Capuano
- & Marco Cippitelli
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Article
| Open AccessAlcohol-abuse drug disulfiram targets pediatric glioma via MLL degradation
- Stefanie Meier
- , Sandra Cantilena
- & David Michod
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Article
| Open AccessALCAP2 inhibits lung adenocarcinoma cell proliferation, migration and invasion via the ubiquitination of β-catenin by upregulating the E3 ligase NEDD4L
- Weijie Zhang
- , Ruochen Zhang
- & Jian-an Huang
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Article
| Open AccessIL-37b alleviates endothelial cell apoptosis and inflammation in Kawasaki disease through IL-1R8 pathway
- Chang Jia
- , Yingzhi Zhuge
- & Maoping Chu
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Article
| Open AccessTargeting STAT3 signaling overcomes gefitinib resistance in non-small cell lung cancer
- Zhe Liu
- , Liang Ma
- & Xue Wang
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Article
| Open AccessBKM120 sensitizes glioblastoma to the PARP inhibitor rucaparib by suppressing homologous recombination repair
- Shaolu Zhang
- , Xin Peng
- & Dexin Kong
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Article
| Open AccessMetalloproteinase 1 downregulation in neurofibromatosis 1: Therapeutic potential of antimalarial hydroxychloroquine and chloroquine
- Gaku Tsuji
- , Ayako Takai-Yumine
- & Masutaka Furue
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Article
| Open AccessKartogenin prevents cartilage degradation and alleviates osteoarthritis progression in mice via the miR-146a/NRF2 axis
- Mingzhuang Hou
- , Yijian Zhang
- & Xuesong Zhu
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Article
| Open AccessInterfering with hyaluronic acid metabolism suppresses glioma cell proliferation by regulating autophagy
- Tao Yan
- , Xin Chen
- & Shiguang Zhao
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Article
| Open AccessInhibition of the sonic hedgehog pathway activates TGF-β-activated kinase (TAK1) to induce autophagy and suppress apoptosis in thyroid tumor cells
- Sumei Li
- , Jingxiang Wang
- & Xiulong Xu
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Article
| Open AccessAnti-tumor activity of a novel proteasome inhibitor D395 against multiple myeloma and its lower cardiotoxicity compared with carfilzomib
- Xuxing Shen
- , Chao Wu
- & Lijuan Chen
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Article
| Open AccessDevelopment of a bispecific immune engager using a recombinant malaria protein
- Mie A. Nordmaj
- , Morgan E. Roberts
- & Ali Salanti
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Article
| Open AccessUtidelone inhibits growth of colorectal cancer cells through ROS/JNK signaling pathway
- Fuli Li
- , Tinglei Huang
- & Shuiping Tu