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| Open AccessMolecular modelling studies and in vitro enzymatic assays identified A 4-(nitrobenzyl)guanidine derivative as inhibitor of SARS-CoV-2 Mpro
- Kaio Maciel de Santiago-Silva
- , Priscila Goes Camargo
- & Marcelle de Lima Ferreira Bispo
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| Open AccessDevelopment of a high throughput system to screen compounds that revert the activated hepatic stellate cells to a quiescent-like state
- Yasuhiro Nakano
- , Eiko Saijou
- & Taketomo Kido
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| Open AccessMolecular identification of Proteus mirabilis, Vibrio species leading to CRISPR-Cas9 modification of tcpA and UreC genes causing cholera and UTI
- Muhammad Naveed
- , Fatima Tahir
- & Abdullah F. Alasmari
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| Open AccessDesign, synthesis, biological assessment and molecular modeling studies of novel imidazothiazole-thiazolidinone hybrids as potential anticancer and anti-inflammatory agents
- Payal Kamboj
- , Anjali
- & Mohd. Amir
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| Open AccessUsing Mendelian randomization provides genetic insights into potential targets for sepsis treatment
- Rui Xia
- , Meng Sun
- & Jianhua Li
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| Open AccessAnticancer, antioxidant, and antibacterial activity of chemically fingerprinted extract from Cyclamen persicum Mill.
- Fuad Al-Rimawi
- , Mahmoud Khalid
- & Mohammed Bourhia
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| Open AccessTranslational research of boron neutron capture therapy for spinal cord gliomas using rat model
- Ryo Kayama
- , Kohei Tsujino
- & Masahiko Wanibuchi
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| Open AccessDP2 receptor activity sensor suited for antagonist screening and measurement of receptor dynamics in real-time
- Michael Kurz
- , Michaela Ulrich
- & Moritz Bünemann
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| Open AccessDevelopment of chitosan lipid nanoparticles to alleviate the pharmacological activity of piperine in the management of cognitive deficit in diabetic rats
- Asmaa Badawy Darwish
- , Amira Mohamed Mohsen
- & Mostafa Mohamed Younis
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| Open AccessTDF and TAF inhibit liver cancer cell migration, invasion via p7TP3
- Jing Zhao
- , Li Zhou
- & Xiuling Li
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| Open AccessInferring molecular inhibition potency with AlphaFold predicted structures
- Pedro F. Oliveira
- , Rita C. Guedes
- & Andre O. Falcao
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| Open AccessHibiscus manihot L. flower extract induces anticancer activity through modulation of apoptosis and autophagy in A549 cells
- Minglu Xu
- , Mengxia Zhao
- & Guoying Yu
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| Open AccessInvestigation into safflower injection as a prophylactic treatment for retinal vein occlusion in a rabbit model
- Junling Li
- , Zhenfeng Guo
- & Jianguo Wu
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| Open AccessEZH2 as a major histone methyltransferase in PDGF-BB-activated orbital fibroblast in the pathogenesis of Graves’ ophthalmopathy
- Sopita Visamol
- , Tanapat Palaga
- & Sita Virakul
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| Open AccessNobiletin alleviates cisplatin-induced ototoxicity via activating autophagy and inhibiting NRF2/GPX4-mediated ferroptosis
- Wenao Song
- , Li Zhang
- & Zhiming Lu
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| Open AccessAI is a viable alternative to high throughput screening: a 318-target study
- Izhar Wallach
- , Denzil Bernard
- & Abraham Heifets
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| Open AccessRosemary and neem: an insight into their combined anti-dandruff and anti-hair loss efficacy
- Mona M. Hashem
- , Dalia Attia
- & Maha M. Salama
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| Open AccessThe antihyperglycemic potential of pyrazolobenzothiazine 1, 1-dioxide novel derivative in mice using integrated molecular pharmacological approach
- Saman Taj
- , Usman Ali Ashfaq
- & Anwarul Hasan
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| Open AccessUTRN as a potential biomarker in breast cancer: a comprehensive bioinformatics and in vitro study
- Han Li
- , Wenjie Zhang
- & Yang Peng
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| Open AccessAnethole as a promising antidepressant for maternal separation stress in mice by modulating oxidative stress and nitrite imbalance
- Najmeh Rostami-Faradonbeh
- , Hossein Amini-Khoei
- & Zahra Lorigooini
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| Open AccessA combination of virtual screening, molecular dynamics simulation, MM/PBSA, ADMET, and DFT calculations to identify a potential DPP4 inhibitor
- Fateme Zare
- , Elaheh Ataollahi
- & Leila Emami
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| Open AccessB-Myb deficiency boosts bortezomib-induced immunogenic cell death in colorectal cancer
- Yuan-Jian Hui
- , Ting-Ting Yu
- & Wei-Xing Wang
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| Open AccessSynthesis and biological evaluation of echinomycin analogues as potential colon cancer agent
- Keita Kojima
- , Hiroaki Konishi
- & Satoshi Ichikawa
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| Open AccessTenovin 3 induces apoptosis and ferroptosis in EGFR 19del non small cell lung cancer cells
- Sha Lv
- , Qianrong Pan
- & Xueping Lei
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| Open AccessComparison of efficacy and safety of equivalent doses of remimazolam versus propofol for gastroscopy anesthesia in elderly patients
- Di Chen
- , Min Liao
- & Hu Sun
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| Open AccessDesign, synthesis and bioactivity study on oxygen-heterocyclic-based pyran analogues as effective P-glycoprotein-mediated multidrug resistance in MCF-7/ADR cell
- Ashraf H. F. Abd El-Wahab
- , Rita M. A. Borik
- & Ahmed M. El-Agrody
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| Open AccessPodocalyxin promotes the formation of compact and chemoresistant cancer spheroids in high grade serous carcinoma
- Ngoc Le Tran
- , Yao Wang
- & Guiying Nie
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| Open AccessNetwork pharmacology, computational biology integrated surface plasmon resonance technology reveals the mechanism of ellagic acid against rotavirus
- Jiangang Zheng
- , Abdul Haseeb
- & Hejie Wang
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| Open AccessA new DNA aptamer which binds to SARS-CoV-2 spike protein and reduces pro-inflammatory response
- Woong Kim
- , Eun Su Song
- & Seok-Jun Kim
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| Open AccessCoumarin linked to 2-phenylbenzimidazole derivatives as potent α-glucosidase inhibitors
- Mina Sadeghi Ganjeh
- , Ali Mazlomifar
- & Shiva Khalili Moghaddam
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| Open AccessReal-time analysis of osteoclast resorption and fusion dynamics in response to bone resorption inhibitors
- Preety Panwar
- , Jacob Bastholm Olesen
- & Dieter Brömme
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| Open AccessEffect of sulfasalazine on ferroptosis during intestinal injury in rats after liver transplantation
- Wei Wu
- , Wenhao Bu
- & Yongwang Wang
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| Open AccessEscherichia coli has an undiscovered ability to inhibit the growth of both Gram-negative and Gram-positive bacteria
- Ertan Kastrat
- & Hai-Ping Cheng
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| Open AccessGEFormerDTA: drug target affinity prediction based on transformer graph for early fusion
- Youzhi Liu
- , Linlin Xing
- & Maozu Guo
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| Open AccessOvercoming radioresistance of breast cancer cells with MAP4K4 inhibitors
- Yun-Suk Kwon
- , Min-Gu Lee
- & Soyoung Kim
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| Open AccessPotential diagnostic and drug target markers in glioblastoma
- Hina Ahsan
- , Muhammad Asghar
- & Shaukat Iqbal Malik
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| Open AccessNetwork pharmacology analysis and experimental validation to explore the mechanism of kaempferol in the treatment of osteoporosis
- Qi Dong
- , Guoxia Ren
- & Dingjun Hao
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| Open AccessBackground and clinical significance of biomarker-based patient enrichment in non-small-cell lung cancer drug development
- Kenji Harada
- & Shunsuke Ono
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| Open AccessNuciferine reduces vascular leakage and improves cardiac function in acute myocardial infarction by regulating the PI3K/AKT pathway
- Wei Xie
- , Shumin Chen
- & Dongjin Wang
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| Open AccessFully connected-convolutional (FC-CNN) neural network based on hyperspectral images for rapid identification of P. ginseng growth years
- Xingfeng Chen
- , Hejuan Du
- & Shu Liu
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| Open AccessA comprehensive computational study to explore promising natural bioactive compounds targeting glycosyltransferase MurG in Escherichia coli for potential drug development
- Amneh Shtaiwi
- , Shafi Ullah Khan
- & Samir Chtita
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| Open AccessCorrelation analysis of disulfidptosis-related gene signatures with clinical prognosis and immunotherapy response in sarcoma
- Juan Xu
- , Kangwen Guo
- & Chao Wang
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| Open AccessValency based novel quantitative structure property relationship (QSPR) approach for predicting physical properties of polycyclic chemical compounds
- Ali Raza
- , Mishal Ismaeel
- & Fikadu Tesgera Tolasa
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| Open AccessPharmacokinetic and pharmacodynamic evaluation study of etomidate: a randomized, open-label, 2-period crossover study in healthy Chinese subjects
- Ying Ding
- , Nan-nan Chu
- & Qing He
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| Open Access1,2,3-triazole and chiral Schiff base hybrids as potential anticancer agents: DFT, molecular docking and ADME studies
- Yonas Belay
- , Alfred Muller
- & Abel K. Oyebamiji
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| Open AccessA highly selective mPGES-1 inhibitor to block abdominal aortic aneurysm progression in the angiotensin mouse model
- Lauren M. Weaver
- , Madeline J. Stewart
- & Chang-Guo Zhan
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| Open AccessN-benzyl-N-methyldecan-1-amine, derived from garlic, and its derivative alleviate 2,4-dinitrochlorobenzene-induced atopic dermatitis-like skin lesions in mice
- Ji Eun Kim
- , Phatcharaporn Budluang
- & Young-Hwa Chung
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| Open AccessLysine demethylase LSD1 is associated with stemness in EBV-positive B cell lymphoma
- Joo Hyun Kim
- , Chaehwa Park
- & Won Seog Kim
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| Open AccessEnhancing explainable SARS-CoV-2 vaccine development leveraging bee colony optimised Bi-LSTM, Bi-GRU models and bioinformatic analysis
- Dilber Uzun Ozsahin
- , Zubaida Said Ameen
- & Auwalu Saleh Mubarak