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Epigenetic modulation through BET bromodomain inhibitors as a novel therapeutic strategy for progranulin-deficient frontotemporal dementia
- Zachary C. Rosenthal
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Development of a high throughput system to screen compounds that revert the activated hepatic stellate cells to a quiescent-like state
- Yasuhiro Nakano
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DP2 receptor activity sensor suited for antagonist screening and measurement of receptor dynamics in real-time
- Michael Kurz
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Inferring molecular inhibition potency with AlphaFold predicted structures
- Pedro F. Oliveira
- , Rita C. Guedes
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AI is a viable alternative to high throughput screening: a 318-target study
- Izhar Wallach
- , Denzil Bernard
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Ultra-high throughput-based screening for the discovery of antiplatelet drugs affecting receptor dependent calcium signaling dynamics
- Delia I. Fernández
- , Sara Troitiño
- & Johan W. M. Heemskerk
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Characterization of human iPSC-derived sensory neurons and their functional assessment using multi electrode array
- Minami Hiranuma
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- & Tomohisa Watanabe
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Digital pathology with artificial intelligence analysis provides insight to the efficacy of anti-fibrotic compounds in human 3D MASH model
- Radina Kostadinova
- , Simon Ströbel
- & Mathieu Petitjean
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Restoring functional TDP-43 oligomers in ALS and laminopathic cellular models through baicalein-induced reconfiguration of TDP-43 aggregates
- Hsiang-Yu Chang
- & I-Fan Wang
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Novel antimicrobial peptides against Cutibacterium acnes designed by deep learning
- Qichang Dong
- , Shaohua Wang
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Hepa-ToxMOA: a pathway-screening method for evaluating cellular stress and hepatic metabolic-dependent toxicity of natural products
- Se-Myo Park
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Process optimization for green synthesis of silver nanoparticles using Rubus discolor leaves extract and its biological activities against multi-drug resistant bacteria and cancer cells
- Saeed Ghasemi
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High-throughput screening assay for PARP-HPF1 interaction inhibitors to affect DNA damage repair
- Saurabh S. Dhakar
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A scalable platform for efficient CRISPR-Cas9 chemical-genetic screens of DNA damage-inducing compounds
- Kevin Lin
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Bezafibrate attenuates immobilization-induced muscle atrophy in mice
- Satoshi Nakamura
- , Yuiko Sato
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Bioadhesive behaviors of HPMC E5: comparative analysis of various techniques, histological and human radiological evidence
- Omar Y. Mady
- , Omar Dewedar
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Comparative assessment of phenolic composition profile and biological activities of green extract and conventional extracts of Salvia sclarea
- Mohammed Mansour Quradha
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A miniaturized mode-of-action profiling platform enables high throughput characterization of the molecular and cellular dynamics of EZH2 inhibition
- Lilia Falkenstern
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Network pharmacology prediction and molecular docking-based strategy to explore the potential mechanism of Radix Astragali against hypopharyngeal carcinoma
- Jianing Zhang
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Novel betulin derivatives as multidrug reversal agents targeting P-glycoprotein
- Jerónimo Laiolo
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Limited high-throughput screening compatibility of the phenuivirus cap-binding domain
- Janna Scherf
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Transfer learning for versatile and training free high content screening analyses
- Maxime Corbe
- , Gaëlle Boncompain
- & Auguste Genovesio
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Network pharmacology-based research on the effect of Radix Astragali on osteosarcoma and the underlying mechanism
- Yafang Zhang
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Semisynthesis of 5-O-ester derivatives of renieramycin T and their cytotoxicity against non-small-cell lung cancer cell lines
- Koonchira Buaban
- , Bhurichaya Innets
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Structure-based discovery of novel P-glycoprotein inhibitors targeting the nucleotide binding domains
- Laust Moesgaard
- , Maria L. Pedersen
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Evaluating the antioxidant potential of resveratrol-gold nanoparticles in preventing oxidative stress in endothelium on a chip
- Farzaneh Fayazbakhsh
- , Fatemeh Hataminia
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High-throughput analysis system of interaction kinetics for data-driven antibody design
- Ryo Matsunaga
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Synthesis, molecular docking, and in vivo antidiabetic evaluation of new benzylidene-2,4-thiazolidinediones as partial PPAR-γ agonists
- Asim Najmi
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Artificial axons as a biomimetic 3D myelination platform for the discovery and validation of promyelinating compounds
- Anna Jagielska
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To investigate the mechanism of Yiwei Decoction in the treatment of premature ovarian insufficiency-related osteoporosis using transcriptomics, network pharmacology and molecular docking techniques
- Weisen Fan
- , Yan Meng
- & Xin Xiu
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The anticancer and antibacterial potential of bioactive secondary metabolites derived From bacterial endophytes in association with Artemisia absinthium
- Mohammad Sadegh Damavandi
- , Hasan Shojaei
- & Bahram Nasr Esfahani
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Multiple green spectroscopic methods for erdosteine determination in bulk and dosage form with extensive greenness evaluation
- Hadeel A. Khalil
- , Eman I. El-Kimary
- & Tarek S. Belal
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Unlocking potential inhibitors for Bruton's tyrosine kinase through in-silico drug repurposing strategies
- Mohammed Alrouji
- , Lizy Sonia Benjamin
- & Atiya Akhtar
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Computational screen for sex-specific drug effects in a cardiac fibroblast signaling network model
- Kelsey M. Watts
- , Wesley Nichols
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Identification of side effects of COVID-19 drug candidates on embryogenesis using an integrated zebrafish screening platform
- Alexander Ernst
- , Indre Piragyte
- & Nadia Mercader
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Discovery of a cystathionine γ-lyase (CSE) selective inhibitor targeting active-site pyridoxal 5′-phosphate (PLP) via Schiff base formation
- Honami Echizen
- , Kenjiro Hanaoka
- & Yasuteru Urano
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Simultaneous LC–MS/MS method for the quantitation of Azithromycin, Hydroxychloroquine and its metabolites in SARS-CoV-2(−/ +) populations using dried blood spots
- Yashpal S. Chhonker
- , Wafaa N. Aldhafiri
- & Daryl J. Murry
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New drug discovery of cardiac anti-arrhythmic drugs: insights in animal models
- Ashish Kumar Sharma
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- & Arun Garg
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Label-free drug response evaluation of human derived tumor spheroids using three-dimensional dynamic optical coherence tomography
- Ibrahim Abd El-Sadek
- , Larina Tzu-Wei Shen
- & Yoshiaki Yasuno
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Novel quinazoline-1,2,3-triazole hybrids with anticancer and MET kinase targeting properties
- Motahareh Mortazavi
- , Masoomeh Eskandari
- & Omidreza Firuzi
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Identification of potential new COVID-19 treatments via RWD-driven drug repurposing
- Yun Liao
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A multi-targeted computational drug discovery approach for repurposing tetracyclines against monkeypox virus
- Thamir A. Alandijany
- , Mai M. El-Daly
- & Esam I. Azhar
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In vitro synergy screens of FDA-approved drugs reveal novel zidovudine- and azithromycin-based combinations with last-line antibiotics against Klebsiella pneumoniae
- Marta Gómara-Lomero
- , Ana Isabel López-Calleja
- & Santiago Ramón-García
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Substituted salicylic acid analogs offer improved potency against multidrug-resistant Neisseria gonorrhoeae and good selectivity against commensal vaginal bacteria
- Hanan Almolhim
- , Ahmed E. M. Elhassanny
- & Paul R. Carlier
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Green “turn-off” luminescent nanosensors for the sensitive determination of desperately fluorescent antibacterial antiviral agent and its metabolite in various matrices
- Hadil M. Elbardisy
- , Mai M. Elnaggar
- & Amira F. El-Yazbi
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Evaluation of drug-induced liver toxicity of trovafloxacin and levofloxacin in a human microphysiological liver model
- Tim Kaden
- , Katja Graf
- & Martin Raasch
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Cisplatin exhibits superiority over MMC as a perfusion agent in a peritoneal mesothelioma patient specific organoid HIPEC platform
- Steven D. Forsythe
- , Richard A. Erali
- & Konstantinos I. Votanopoulos
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OrganoidChip facilitates hydrogel-free immobilization for fast and blur-free imaging of organoids
- Khashayar Moshksayan
- , Anirudha Harihara
- & Adela Ben-Yakar
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Fluorescence lifetime FRET assay for live-cell high-throughput screening of the cardiac SERCA pump yields multiple classes of small-molecule allosteric modulators
- Osha Roopnarine
- , Samantha L. Yuen
- & David D. Thomas
Predicting FFAR4 agonists using structure-based machine learning approach based on molecular fingerprints